Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Paul Geeleher"'
Autor:
Richard H. Chapple, Xueying Liu, Sivaraman Natarajan, Margaret I. M. Alexander, Yuna Kim, Anand G. Patel, Christy W. LaFlamme, Min Pan, William C. Wright, Hyeong-Min Lee, Yinwen Zhang, Meifen Lu, Selene C. Koo, Courtney Long, John Harper, Chandra Savage, Melissa D. Johnson, Thomas Confer, Walter J. Akers, Michael A. Dyer, Heather Sheppard, John Easton, Paul Geeleher
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-26 (2024)
Abstract Background Neuroblastoma is a common pediatric cancer, where preclinical studies suggest that a mesenchymal-like gene expression program contributes to chemotherapy resistance. However, clinical outcomes remain poor, implying we need a bette
Externí odkaz:
https://doaj.org/article/fc1c31cafd514273af4f2d422016e1f2
Autor:
Hyeong-Min Lee, William C. Wright, Min Pan, Jonathan Low, Duane Currier, Jie Fang, Shivendra Singh, Stephanie Nance, Ian Delahunty, Yuna Kim, Richard H. Chapple, Yinwen Zhang, Xueying Liu, Jacob A. Steele, Jun Qi, Shondra M. Pruett-Miller, John Easton, Taosheng Chen, Jun Yang, Adam D. Durbin, Paul Geeleher
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Combination chemotherapy is crucial for successfully treating cancer. However, the enormous number of possible drug combinations means discovering safe and effective combinations remains a significant challenge. To improve this process, we c
Externí odkaz:
https://doaj.org/article/8ea60511d9b646e7b01a18ad97adfba0
Autor:
Min Pan, William C. Wright, Richard H. Chapple, Asif Zubair, Manbir Sandhu, Jake E. Batchelder, Brandt C. Huddle, Jonathan Low, Kaley B. Blankenship, Yingzhe Wang, Brittney Gordon, Payton Archer, Samuel W. Brady, Sivaraman Natarajan, Matthew J. Posgai, John Schuetz, Darcie Miller, Ravi Kalathur, Siquan Chen, Jon Patrick Connelly, M. Madan Babu, Michael A. Dyer, Shondra M. Pruett-Miller, Burgess B. Freeman, Taosheng Chen, Lucy A. Godley, Scott C. Blanchard, Elizabeth Stewart, John Easton, Paul Geeleher
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
CX-5461 recently progressed through phase I clinical trial as a first-inhuman inhibitor of RNA-POL I. Here, the authors demonstrate that CX-5461 synergizes with topoisomerase I inhibitors to inhibit neuroblastoma cells and that its primary target in
Externí odkaz:
https://doaj.org/article/eab356ebc3d24e3c88297e4fc7fbc176
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 10, p e1010278 (2022)
Gene set analysis (GSA) remains a common step in genome-scale studies because it can reveal insights that are not apparent from results obtained for individual genes. Many different computational tools are applied for GSA, which may be sensitive to d
Externí odkaz:
https://doaj.org/article/6743d93f9a4946f094a3a7b70f7640e7
Autor:
Paul Geeleher, Aritro Nath, Fan Wang, Zhenyu Zhang, Alvaro N. Barbeira, Jessica Fessler, Robert L. Grossman, Cathal Seoighe, R. Stephanie Huang
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-14 (2018)
Abstract Expression quantitative trait loci (eQTLs) identified using tumor gene expression data could affect gene expression in cancer cells, tumor-associated normal cells, or both. Here, we have demonstrated a method to identify eQTLs affecting expr
Externí odkaz:
https://doaj.org/article/e4f470171d0742da96bd7091e0814b55
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93420 (2014)
It has long been observed that tamoxifen sensitivity varies among breast cancer patients. Further, ethnic differences of tamoxifen therapy between Caucasian and African American have also been reported. Since most studies have been focused on Caucasi
Externí odkaz:
https://doaj.org/article/54f784bada254275bf72380f2489aea9
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107468 (2014)
We recently described a methodology that reliably predicted chemotherapeutic response in multiple independent clinical trials. The method worked by building statistical models from gene expression and drug sensitivity data in a very large panel of ca
Externí odkaz:
https://doaj.org/article/3038fd9635fa41aeb3311f8dcfc7351a
Autor:
Richard H. Chapple, Xueying Liu, Sivaraman Natarajan, Margaret I.M. Alexander, Yuna Kim, Anand G. Patel, Christy W. LaFlamme, Min Pan, William C. Wright, Hyeong-Min Lee, Yinwen Zhang, Meifen Lu, Selene C. Koo, Courtney Long, John Harper, Chandra Savage, Melissa D. Johnson, Thomas Confer, Walter J. Akers, Michael A. Dyer, Heather Sheppard, John Easton, Paul Geeleher
Neuroblastoma is a common pediatric cancer, where preclinical studies have suggested chemotherapy resistance is driven by a mesenchymal-like gene expression program. However, the poor clinical outcomes imply we need a better understanding of the rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90ac36f096d7467cac33a3f05a5d353e
https://doi.org/10.1101/2023.04.13.536639
https://doi.org/10.1101/2023.04.13.536639
Autor:
Hyeong-Min Lee, William C. Wright, Min Pan, Jonathan Low, Duane Currier, Jie Fang, Shivendra Singh, Stephanie Nance, Ian Delahunty, Yuna Kim, Richard H. Chapple, Yinwen Zhang, Xueying Liu, Jacob A. Steele, Jun Qi, Shondra M. Pruett-Miller, John Easton, Taosheng Chen, Jun Yang, Adam D. Durbin, Paul Geeleher
Combination chemotherapy is crucial for achieving durable cancer cures, however, developing safe and effective drug combinations has been a significant challenge. To improve this process, we conducted large-scale targeted CRISPR knockout screens in d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46d5f67262f1c194f9536abb26a8b55f
https://doi.org/10.1101/2023.04.12.536612
https://doi.org/10.1101/2023.04.12.536612
Autor:
Paul Geeleher, Heather Tillman, William C. Wright, John Easton, Richard H. Chapple, Hyeong-Min Lee, Sivaraman Natarajan, Asif Zubair, Min Pan
Spatial transcriptomics technologies have recently emerged as a powerful tool for measuring spatially resolved gene expression directly in tissues sections, revealing cell types and their dysfunction in unprecedented detail. However, spatial transcri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9f9dfb5b01b6fee32f6cabe47c8e8b7
https://doi.org/10.1101/2021.11.10.468082
https://doi.org/10.1101/2021.11.10.468082