Ibrutinib significantly inhibited Bruton’s tyrosine kinase (BTK) phosphorylation,in-vitro proliferation and enhanced overall survival in a preclinical Burkitt lymphoma (BL) model

Autor: Yaya Chu, Sanghoon Lee, Tishi Shah, Changhong Yin, Matthew Barth, Rodney R. Miles, Janet Ayello, Erin Morris, Lauren Harrison, Carmella Van de Ven, Paul Galardy, Stanton C. Goldman, Megan S. Lim, Michelle Hermiston, Linda M. McAllister-Lucas, Lisa Giulino-Roth, Sherrie L. Perkins, Mitchell S. Cairo

Publikováno v: OncoImmunology, Vol 8, Iss 1 (2019)

Pediatric and adult patients with recurrent/refractory Burkitt lymphoma (BL) continue to have poor outcomes, emphasizing the need for newer therapeutic agents. Bruton’s tyrosine kinase (BTK) is activated following B-cell receptor stimulation and in

Externí odkaz: https://doaj.org/article/2466fcc030424707a6dd1a4e9329ef32

An Effective Combination Therapy for the Treatment of Pediatric Monomorphic Post-transplant Lymphoproliferative Disorder With Plasmacytic Differentiation

Autor: Mihai Dumbrava, Paul Galardy, Andrew L. Feldman, Alexis Kuhn, Shakila Khan, Asmaa Ferdjallah, Mira A. Kohorst

Publikováno v: Journal of Pediatric Hematology/Oncology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8079dd87b710fe66c5c962fac9a5107c
https://doi.org/10.1097/mph.0000000000002629

Neonatal familial hemophagocytic lymphohistiocytosis diagnosed with ultrarapid whole‐genome sequencing

Autor: Jacob R. Greenmyer, Whitney S. Thompson, Stephanie Mavis, Sara Hassan, Jody Weckwerth, Charlotte Hobbs, Kiely James, Shareef Nahas, Paul Galardy, Christopher Collura

Publikováno v: Pediatric Blood & Cancer. 70

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e56bfd186d6201677699bebf7c18573
https://doi.org/10.1002/pbc.29871

Integrating Research, Quality Improvement, and Medical Education for Better Handoffs and Safer Care: Disseminating, Adapting, and Implementing the I-PASS Program

Autor: Amy J. Starmer, Nancy D. Spector, Daniel C. West, Rajendu Srivastava, Theodore C. Sectish, Christopher P. Landrigan, Aravind Ajakumar Menon, Arshia Ali, Brenda K. Allair, April D. Allen, Nureddin Almaddah, Claire Alminde, Wilma Alvarado-Little, Elizabeth Anson, Michele Ashland, Marisa Atsatt, Megan Aylor, Jennifer D. Baird, James F. Bale, Dorene Balmer, Aisha Barber, Kevin Barton, Kimberly Bates, Carolyn Beck, Kathleen Berchelmann, Renuka Bhan, Zia Bismilla, Rebecca L. Blankenburg, Aileen Boa-Hocbo, Talya Bordin-Wosk, Michelle Brooks, Sharon Calaman, Julie Campe, Maria Lucia Campos, Debra Chandler, Yvonne Cheung, Amanda Choudhary, Eileen Christensen, Katherine Clark, Maitreya Coffey, Sally Coghlan-McDonald, Ellen Cohen, F. Sessions Cole, Elizabeth Corless, Sharon Cray, Roxi Da Silva, Devesh Dahale, Anuj K. Dalal, Lauren A. Destino, Jonathan Doroshow, Benard Dreyer, Katharine duPont, Steven Eagle, Courtney Edgar-Zarate, Angie Etzenhouser, Jennifer L. Everhart, Angela M. Feraco, Alexandra Ferrer, Paul Galardy, Briana M. Garcia, Maria Gaspar-Oishi, Jenna Goldstein, Brian P. Good, Dionne A Graham, Amanda S. Growdon, LeAnn Gubler, Amy Guiot, Charin Hanlon, Mona Hanna-Attisha, Roben Harris, Helen Haskell, Melvyn Hecht, Rebecca S Hehn, Justin Held, Jennifer H. Hepps, Debra Hillier, Mark Hiraoka, Eric Howell, Christine Hrach, Helen Hughes, Charles Huskins, Scott Kaatz, Vishnu Kanala, Michael Kantrowitz, Peter Kaplan, Deanne Kashiwagi, Rajat Kaul, Carol A. Keohane, Jeremy Kern, Alisa Khan, Nazia Naz S. Khan, Barry Kitch, Irene Kocolas, Lara Kothari, Elizabeth Kruvand, Nicholas Kuzma, Mary Lacy, Michele Lane, Kate Langrish, Christy J.W. Ledford, Laura LeRoux, Kheyandra Lewis, Stuart Lipsitz, Katherine P. Litterer, Joseph O. Lopreiato, Aimee Lyons, Avram Mack, Meghan Mallouk, Christopher G. Maloney, Amanda Mangan, Keith Mann, Peggy Markle, Christine Marrese, David Marseille, Greg Maynard, Bijal Mehta, Fernando Mendoza, Alexandra N. Mercer, Dale Micalizzi, Lisa Mims, Vineeta Mittal, Stephanie Mueller, Thuy L. Ngo, Ann Nolan, Christopher Nyenpan, Maria Obermeyer, Katherine O'Donnell, Jennifer K. O'Toole, Mary Ottolini, Mobola Owolabi, Aarti Patel, Rajesh Patel, Shilpa J. Patel, Catherine Perron, Rita Pickler, Alina Popa, Patrick Reppert, Robert Riss, Justin Roesch, Jayne E. Rogers, Glenn Rosenbluth, Jeffrey M. Rothschild, Lee Sanders, Kimberly Sauder, Jeff Schnipper, Kumiko O Schnock, Amy Scholtz, Barry Seltz, Theresa Serra, Janet Serwint, Samir Shah, Meesha Sharma, Kathleen Sheppard, Arabella Simpkin, Karin A Sloan, Lauren G. Solan, Michael W Southgate, Jaime Blank Spackman, Scott M. Stevens, Adam Stevenson, Windy Stevenson, Anupama Subramony, William Surkis, Sudhagar Thangarasu, E. Douglas Thompson, Cheryl Toole, Laura Trueman, Tanner Trujillo, Lisa Tse, Michael P. Turmelle, Vishwas Vaniawala, Tamara Wagner, Cindy Warnick, John Webster, Mary Webster, Adina Weinerman, Chelsea Welch, Andrew J. White, Matthew F. Wien, Ariel S. Winn, Stephanie Wintch, H. Shonna Yin, Catherine S. Yoon, Clifton E. Yu, Dominick Zampino, Katherine R. Zigmont

Publikováno v: Joint Commission journal on quality and patient safety. 43(7)

Background In 2009 the I-PASS Study Group was formed by patient safety, medical education, health services research, and clinical experts from multiple institutions in the United States and Canada. When the I-PASS Handoff Program, which was developed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b83c4a60f25de4f0da2549734003093
https://pubmed.ncbi.nlm.nih.gov/28648217

Mechanism-based proteomics tools based on ubiquitin and ubiquitin-like proteins: crystallography, activity profiling, and protease identification

Autor: Paul, Galardy, Hidde L, Ploegh, Huib, Ovaa

Publikováno v: Methods in enzymology. 399

Isopeptidases that specifically remove ubiquitin or ubiquitin-like molecules from polypeptide adducts are emerging as key regulatory enzymes in a multitude of biochemical pathways. We have developed a set of tools that covalently target the active si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d606d87cc6572c24162827c847c865f1
https://pubmed.ncbi.nlm.nih.gov/16338352