Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Paul G. Thomes"'
Autor:
Abdul Alim Al-Bari, Yuko Ito, Paul G. Thomes, Manoj B. Menon, Marina García-Macia, Raouf Fadel, Alfreda Stadlin, Nicholas Peake, MoezAlIslam Ezzat Faris, Nabil Eid, Daniel J. Klionsky
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Macroautophagy (hereafter referred to as autophagy), a highly conserved metabolic process, regulates cellular homeostasis by degrading dysfunctional cytosolic constituents and invading pathogens via the lysosomal system. In addition, autophagy select
Externí odkaz:
https://doaj.org/article/b1045026d0ce4ede987d00930c609213
Autor:
Carol A. Casey, Amanda J. Macke, Ryan R. Gough, Artem N. Pachikov, Mary E. Morris, Paul G. Thomes, Jacy L. Kubik, Melissa S. Holzapfel, Armen Petrosyan
Publikováno v:
Hepatology Communications, Vol 6, Iss 2, Pp 374-388 (2022)
Previous work from our laboratories has identified multiple defects in endocytosis, protein trafficking, and secretion, along with altered Golgi function after alcohol administration. Manifestation of alcohol‐associated liver disease (ALD) is assoc
Externí odkaz:
https://doaj.org/article/5f87cd9e716049a49068b8f44d773699
Publikováno v:
Cells, Vol 12, Iss 7, p 1013 (2023)
Background: Aggresomes are collections of intracellular protein aggregates. In liver cells of patients with alcoholic hepatitis, aggresomes appear histologically as cellular inclusions known as Mallory–Denk (M–D) bodies. The proteasome is a multi
Externí odkaz:
https://doaj.org/article/3112976093b54ead9b8af75528d30cc4
Publikováno v:
Liver Research, Vol 3, Iss 3, Pp 191-205 (2019)
The review describes research findings on the influence of alcohol consumption on two crucial catabolic systems in hepatocytes: the lysosome and the ubiquitin-proteasome system (UPS). The lysosome is a membrane-bound organelle that degrades all aging
Externí odkaz:
https://doaj.org/article/b36c4a2d5374463eb424148c7019bbb0
Autor:
Karuna Rasineni, Clayton W. Jordan, Paul G. Thomes, Jacy L. Kubik, Elizabeth M. Staab, Sarah A. Sweeney, Geoffrey A. Talmon, Terrence M. Donohue, Mark A. McNiven, Kusum K. Kharbanda, Carol A. Casey
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Background: Fatty liver, a major health problem worldwide, is the earliest pathological change in the progression of alcohol-associated (AFL) and non-alcoholic fatty liver disease (NAFL). Though the causes of AFL and NAFL differ, both share similar h
Externí odkaz:
https://doaj.org/article/e8d23a2791004e61af185919d5388699
Autor:
Carol A. Casey, Terrence M. Donohue, Jr., Jacy L. Kubik, Vikas Kumar, Michael J. Naldrett, Nicholas T. Woods, Cole P. Frisbie, Mark A. McNiven, Paul G. Thomes
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100049- (2021)
Abstract: Lipid droplets (LDs) are composed of neutral lipids enclosed in a phospholipid monolayer, which harbors membrane-associated proteins that regulate LD functions. Despite the crucial role of LDs in lipid metabolism, remodeling of LD protein c
Externí odkaz:
https://doaj.org/article/6960739a40cb475bacb975168dd7143d
Autor:
Moses New-Aaron, Paul G. Thomes, Murali Ganesan, Raghubendra Singh Dagur, Terrence M. Donohue, Kharbanda K. Kusum, Larisa Y. Poluektova, Natalia A. Osna
Publikováno v:
Biomolecules, Vol 11, Iss 10, p 1497 (2021)
Although the causes of hepatotoxicity among alcohol-abusing HIV patients are multifactorial, alcohol remains the least explored “second hit” for HIV-related hepatotoxicity. Here, we investigated whether metabolically derived acetaldehyde impairs
Externí odkaz:
https://doaj.org/article/dd84d8c1002949b4a33f08ac250a2f9a
Autor:
Li Yang, Changqing Yang, Paul G. Thomes, Kusum K. Kharbanda, Carol A. Casey, Mark A. McNiven, Terrence M. Donohue
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
This review describes the influence of ethanol consumption on hepatic lipophagy, a selective form of autophagy during which fat-storing organelles known as lipid droplets (LDs) are degraded in lysosomes. During classical autophagy, also known as macr
Externí odkaz:
https://doaj.org/article/36e3b9441f6f4c62b0de1b0740931970
Publikováno v:
Data in Brief, Vol 10, Iss C, Pp 312-314 (2017)
Our data describe autophagic flux in primary rat hepatic stellate cells (rHSCs) treated with pro-fibrotic growth factor, transforming growth factor beta (TGF-β). An autophagy flux experiment determines the rate of synthesis and degradation of the au
Externí odkaz:
https://doaj.org/article/8ddac30f081741febe6b80952e4171e3
Publikováno v:
Redox Biology, Vol 3, Iss C, Pp 29-39 (2014)
In this review, we describe research findings on the effects of alcohol exposure on two major catabolic systems in liver cells: the ubiquitin–proteasome system (UPS) and autophagy. These hydrolytic systems are not unique to liver cells; they exist
Externí odkaz:
https://doaj.org/article/d10ecf3ef35c4b528ba61a661c0400b4