Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Paul G. Donlin-Asp"'
Autor:
Paul G. Donlin-Asp, Claudia Fallini, Jazmin Campos, Ching-Chieh Chou, Megan E. Merritt, Han C. Phan, Gary J. Bassell, Wilfried Rossoll
Publikováno v:
Cell Reports, Vol 18, Iss 7, Pp 1660-1673 (2017)
Spinal muscular atrophy (SMA) is a motor neuron disease caused by reduced levels of the survival of motor neuron (SMN) protein. SMN is part of a multiprotein complex that facilitates the assembly of spliceosomal small nuclear ribonucleoproteins (snRN
Externí odkaz:
https://doaj.org/article/0a8ea1b0aa38402bab1ce8c4168249f7
Autor:
Dexter A Myrick, Michael A Christopher, Alyssa M Scott, Ashley K Simon, Paul G Donlin-Asp, William G Kelly, David J Katz
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177473 (2017)
The proper regulation of spermatogenesis is crucial to ensure the continued production of sperm and fertility. Here, we investigated the function of the H3K4me2 demethylase KDM1A/LSD1 during spermatogenesis in developing and adult mice. Conditional d
Externí odkaz:
https://doaj.org/article/396e3ed1be2642058c6af052d0af5758
Autor:
Paul G. Donlin-Asp, Alexander Heckel, Robin Klimek, Erin M. Schuman, Vanessa Hanff, Claudio Polisseni
Publikováno v:
Chemical Communications. 57:12683-12686
Herein, we present a new class of Q-dye molecular beacons (MBs) that can be locally activated with visible light in hippocampal neurons. Our novel architecture increases the available monitoring time for neuronal mRNA from several minutes to 14 hours
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c17457d7d0e110ee62bc99a3dfbf6716
https://doi.org/10.1039/d1cc05664f
https://doi.org/10.1039/d1cc05664f
Autor:
David J. A. Wyllie, Sonal Kedia, Paul G. Donlin-Asp, Sumantra Chattarji, Pradeep K. Mishra, Mohammad Sarfaraz Nawaz, Erin M. Schuman, Peter C. Kind, Giselle Fernandes, Mohammed Mostafizur Rahman, Aiman Kayenaat, Anupam Hazra, Dheeraj Songara
Publikováno v:
Cell Rep.
Fragile X syndrome (FXS), a commonly inherited form of autism and intellectual disability, is associated with emotional symptoms that implicate dysfunction of the amygdala. However, current understanding of the pathogenesis of the disease is based pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e799bbf7a8522e4560eeecf528af8083
Publikováno v:
Curr Opin Neurobiol
Neurons exhibit a unique degree of spatial compartmentalization and are able to maintain and remodel their proteomes independently from the cell body. While much effort has been devoted to understanding the capacity and role for local protein synthes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34dbf2b1a1802f4c4fe0d7932b018016
https://doi.org/10.1016/j.conb.2019.02.008
https://doi.org/10.1016/j.conb.2019.02.008
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences (PNAS)
Proceedings of the National Academy of Sciences (PNAS)
Significance Local protein synthesis is important for neuronal function and synaptic plasticity. Thousands of mRNAs are found in axons and dendrites, and it is believed that regulating their dynamic transport and distribution is a key determinant of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::105a3a039a9f074a678dd88c75ef8f13
http://europepmc.org/articles/PMC8020670
http://europepmc.org/articles/PMC8020670
Autor:
Mike Heilemann, Marina S. Dietz, Ralf Jungmann, Hans-Dieter Barth, Erin M. Schuman, Alexander Auer, Paul G. Donlin-Asp, Maximilian T. Strauss, Nina S. Deussner-Helfmann, Sebastian Malkusch
Publikováno v:
Single Molecule Spectroscopy and Superresolution Imaging XIII.
Correlating DNA-PAINT (point accumulation for imaging in nanoscale topography) and single-molecule FRET (Forster resonance energy transfer) enables the multiplexed detection with sub-diffraction optical resolution. We designed pairs of short oligonuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af0101f45d3b7272833752df086e8d3f
https://doi.org/10.1117/12.2550629
https://doi.org/10.1117/12.2550629
Autor:
Daniela C. Zarnescu, Spencer Vaughan, Maureen A. Powers, Feilin Liu, Ching Chieh Chou, Chadwick M. Hales, Kevin B. Boylan, Yi Zhang, Marla Gearing, Thomas Kukar, Nicholas T. Seyfried, Melissa Sayegh, Wilfried Rossoll, Duc M. Duong, Mfon E. Umoh, Leonard Petrucelli, Paul G. Donlin-Asp, Rita Sattler, Yu Han Chen, Dennis W. Dickson, Jonathan D. Glass, Yong Jie Zhang, Ileana Lorenzini, Rosa Rademakers, Nigel J. Cairns
Publikováno v:
Nature neuroscience
The cytoplasmic mislocalization and aggregation of TAR DNA-binding protein-43 (TDP-43) is a common histopathological hallmark of the amyotrophic lateral sclerosis and frontotemporal dementia disease spectrum (ALS/FTD). However, the composition of agg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6181d00784164d71304af7b443120dd
http://europepmc.org/articles/PMC5800968
http://europepmc.org/articles/PMC5800968
Publikováno v:
FEBS Letters. 591:1508-1525
Coordinated regulation of mRNA localization and local translation are essential steps in cellular asymmetry and function. It is increasingly evident that mRNA-binding proteins play critical functions in controlling the fate of mRNA, including when an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060e897c876642a2e637c9169b53dd27
https://doi.org/10.1002/1873-3468.12621
https://doi.org/10.1002/1873-3468.12621