Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Paul G. DeCaen"'
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Voltage-gated sodium (Nav) channels are crucial for action potential initiation in excitable cells. Here the authors present the complete structure of prokaryotic NavMs in a fully open state, providing structural insight into the opening and closure
Externí odkaz:
https://doaj.org/article/e9790fdf9aa34bac8509eea7e2e8e3c1
Publikováno v:
Annu Rev Physiol
Polycystin subunits can form hetero- and homotetrameric ion channels in the membranes of various compartments of the cell. Homotetrameric polycystin channels are voltage- and calcium-modulated, whereas heterotetrameric versions are proposed to be lig
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Polycystins (PKD2, PKD2L1, and PKD2L2) are members of the transient receptor potential family, which form ciliary ion channels. Most notably, PKD2 dysregulation in the kidney nephron cilia is associated with polycystic kidney disease, but the functio
Autor:
Leo CT Ng, Brandon J Harris, Megan Larmore, My C Ta, Thuy N Vien, Valerie L Tokars, Vladimir Yarov‐Yarovoy, Paul G DeCaen
Publikováno v:
EMBO reports.
Publikováno v:
eLife, Vol 7 (2018)
Mutations in the polycystin genes, PKD1 or PKD2, results in Autosomal Dominant Polycystic Kidney Disease (ADPKD). Although a genetic basis of ADPKD is established, we lack a clear understanding of polycystin proteins’ functions as ion channels. Thi
Externí odkaz:
https://doaj.org/article/1316725f3ce14c489a7b1855b8cfe8a7
Publikováno v:
Biophysical Journal. 122:321a
Publikováno v:
Biophysical Journal. 122:395a
Publikováno v:
eLife, Vol 5 (2016)
Native PKD2-L1 channel subunits are present in primary cilia and other restricted cellular spaces. Here we investigate the mechanism for the channel's unusual regulation by external calcium, and rationalize this behavior to its specialized function.
Externí odkaz:
https://doaj.org/article/c3b438efcb634f2c8ee9aafcb8a9ac43
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance How do variants that cause autosomal dominant polycystic kidney disease (ADPKD) alter the structure and function of polycystin-2 channels? This 20-y-old question remains unanswered because polycystins traffic to organelle membranes, such
Autor:
Megan M. McCollum, Megan Larmore, Shingo Ishihara, Leo C.T. Ng, Louise F. Kimura, Eduardo Guadarrama, My C. Ta, Thuy N. Vien, Grant B. Frost, Karl A. Scheidt, Rachel E. Miller, Paul G. DeCaen
Publikováno v:
Cell Rep
Voltage-gated sodium channels (Na(V)) in nociceptive neurons initiate action potentials required for transmission of aberrant painful stimuli observed in osteoarthritis (OA). Targeting these Na(V) subtypes with drugs to produce analgesic effects for