Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Paul G. DeCaen"'
Publikováno v:
eLife, Vol 13 (2024)
Ion channels are biological transistors that control ionic flux across cell membranes to regulate electrical transmission and signal transduction. They are found in all biological membranes and their conductive state kinetics are frequently disrupted
Externí odkaz:
https://doaj.org/article/a209b4f45c1b4bcf8b64d63e4fd03c4e
Publikováno v:
Annu Rev Physiol
Polycystin subunits can form hetero- and homotetrameric ion channels in the membranes of various compartments of the cell. Homotetrameric polycystin channels are voltage- and calcium-modulated, whereas heterotetrameric versions are proposed to be lig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e3ea71f7e1b4b6a0c2ede747fed375
https://doi.org/10.1146/annurev-physiol-031522-084334
https://doi.org/10.1146/annurev-physiol-031522-084334
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Voltage-gated sodium (Nav) channels are crucial for action potential initiation in excitable cells. Here the authors present the complete structure of prokaryotic NavMs in a fully open state, providing structural insight into the opening and closure
Externí odkaz:
https://doaj.org/article/e9790fdf9aa34bac8509eea7e2e8e3c1
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Polycystins (PKD2, PKD2L1, and PKD2L2) are members of the transient receptor potential family, which form ciliary ion channels. Most notably, PKD2 dysregulation in the kidney nephron cilia is associated with polycystic kidney disease, but the functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab3badef2e44bdedd1a92d3d135e7a80
https://doi.org/10.1073/pnas.2219686120
https://doi.org/10.1073/pnas.2219686120
Autor:
Leo CT Ng, Brandon J Harris, Megan Larmore, My C Ta, Thuy N Vien, Valerie L Tokars, Vladimir Yarov‐Yarovoy, Paul G DeCaen
Publikováno v:
EMBO reports.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::172e9c97826c3fd5ecaed341a9c4ced2
https://doi.org/10.15252/embr.202356783
https://doi.org/10.15252/embr.202356783
Publikováno v:
eLife, Vol 7 (2018)
Mutations in the polycystin genes, PKD1 or PKD2, results in Autosomal Dominant Polycystic Kidney Disease (ADPKD). Although a genetic basis of ADPKD is established, we lack a clear understanding of polycystin proteins’ functions as ion channels. Thi
Externí odkaz:
https://doaj.org/article/1316725f3ce14c489a7b1855b8cfe8a7
Publikováno v:
eLife, Vol 5 (2016)
Native PKD2-L1 channel subunits are present in primary cilia and other restricted cellular spaces. Here we investigate the mechanism for the channel's unusual regulation by external calcium, and rationalize this behavior to its specialized function.
Externí odkaz:
https://doaj.org/article/c3b438efcb634f2c8ee9aafcb8a9ac43
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance How do variants that cause autosomal dominant polycystic kidney disease (ADPKD) alter the structure and function of polycystin-2 channels? This 20-y-old question remains unanswered because polycystins traffic to organelle membranes, such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f09853b8416779579fa50a07f753e4c
http://europepmc.org/articles/PMC7229662
http://europepmc.org/articles/PMC7229662
Publikováno v:
Biophysical Journal. 122:321a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06cf7f42563613bf196b8eb17020365b
https://doi.org/10.1016/j.bpj.2022.11.1800
https://doi.org/10.1016/j.bpj.2022.11.1800
Publikováno v:
Biophysical Journal. 122:395a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97bfe814d7a39a417d7e72cf14403ac6
https://doi.org/10.1016/j.bpj.2022.11.2156
https://doi.org/10.1016/j.bpj.2022.11.2156