Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Paul G Hynes"'
Autor:
Orla M Casey, Lei Fang, Paul G Hynes, Wassim G Abou-Kheir, Philip L Martin, Heather S Tillman, Gyorgy Petrovics, Hibah O Awwad, Yvona Ward, Ross Lake, Luhua Zhang, Kathleen Kelly
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41668 (2012)
Genomic rearrangements commonly occur in many types of cancers and often initiate or alter the progression of disease. Here we describe an in vivo mouse model that recapitulates the most frequent rearrangement in prostate cancer, the fusion of the pr
Externí odkaz:
https://doaj.org/article/2af905f70f1c48d0bae2e21c214b0f61
Autor:
Wassim Abou-Kheir, Paul G Hynes, Philip Martin, Juan Juan Yin, Yen-Nien Liu, Victoria Seng, Ross Lake, Joshua Spurrier, Kathleen Kelly
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26112 (2011)
Prostate cancers of luminal adenocarcinoma histology display a range of clinical behaviors. Although most prostate cancers are slow-growing and indolent, a proportion is aggressive, developing metastasis and resistance to androgen deprivation treatme
Externí odkaz:
https://doaj.org/article/4aa50a0e75f446608dff9a89b4a7fddb
Autor:
Juan Juan Yin, Michael L. Beshiri, John B. Tucker, R. Mark Simpson, Carleen Klummp-Thomas, Holly M. Nguyen, Caitlin M. Tice, Shelley E Hoover, Lei Fang, Supreet Agarwal, Paul G. Hynes, Ross Lake, Caitlyn Fuller, Eva Corey, Rajarshi Guha, Yasmine C. Abbey, Craig J. Thomas, Keith H. Jansson, Jacob Cawley, Aian Neil Alilin, John K. Simmons, Xiaohu Zhang, Lauren E. Stahl, David A. Proia, Crystal McKnight, Kathleen Kelly
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports
Scientific Reports
The development of new treatments for castrate resistant prostate cancer (CRPC) must address such challenges as intrinsic tumor heterogeneity and phenotypic plasticity. Combined PTEN/TP53 alterations represent a major genotype of CRPC (25–30%) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c00bce7cd425d8baf006e95f352ade8
http://link.springer.com/article/10.1038/s41598-018-35417-0
http://link.springer.com/article/10.1038/s41598-018-35417-0
Autor:
Krista, Kinneer, Matt, Flynn, Suneetha B, Thomas, John, Meekin, Reena, Varkey, Xiaodong, Xiao, Haihong, Zhong, Shannon, Breen, Paul G, Hynes, Ryan, Fleming, Binyam, Bezabeh, Cui Tracy, Chen, Leslie, Wetzel, Ruoyan, Chen, Nazzareno, Dimasi, Yu-Tzu, Tai, Kenneth C, Anderson, Ronald, Herbst, Philip W, Howard, Elaine M, Hurt, David A, Tice
Publikováno v:
Leukemia. 33(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f3af39c8da80648fa1a5430a990fa445
https://pubmed.ncbi.nlm.nih.gov/30315237
https://pubmed.ncbi.nlm.nih.gov/30315237
Autor:
Victoria Seng, Juan Juan Yin, Heather Sheppard-Tillman, Wassim Abou-Kheir, Kathleen Kelly, Orla Casey, Yen-Nien Liu, Paul G. Hynes, Dong Hu, Lei Fang, Yong Wan, Philip Martin
Publikováno v:
Molecular and Cellular Biology. 32:941-953
Epithelial-mesenchymal transition (EMT) is implicated in various pathological processes within the prostate, including benign prostate hyperplasia (BPH) and prostate cancer progression. However, an ordered sequence of signaling events initiating carc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::269bdff8e0023b117b99cb1e2431494f
https://doi.org/10.1128/mcb.06306-11
https://doi.org/10.1128/mcb.06306-11
Autor:
Kathleen Kelly, Ming Yi, Yen-Nien Liu, Lei Fang, Heather Sheppard-Tillman, Victoria Seng, Philip Martin, Juan Juan Yin, Robert M. Stephens, Paul G. Hynes, Wassim Abou-Kheir, Orla Casey
Publikováno v:
Oncogene
Epithelial – mesenchymal transition (EMT) is a developmental program of signaling pathways that determine commitment to epithelial and mesenchymal phenotypes. In the prostate, EMT processes have been implicated in benign prostatic hyperplasia and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88bea281b5274ae0003c7d5f9390c42b
https://doi.org/10.1038/onc.2012.58
https://doi.org/10.1038/onc.2012.58
Autor:
David A. Proia, Crystal Tran, Yasmine C. Abbey, Juan Juan Yin, Lauren E. Stahl, John B. Tucker, Alilin Aian Neil, Supreet Agarwal, John K. Simmons, Lei Fang, Craig J. Thomas, R. Mark Simpson, Xiahu Zhang, Jacob Cawley, Shelley B. Hoover, Michael L. Beshiri, Keith H. Jansson, Caitlyn Fuller, Holly M. Nguyen, Rajarshi Guha, Eva Corey, Paul G. Hynes, Ross Lake, Kathleen Kelly, Caitlin M. Tice
Publikováno v:
Cancer Research. 78:B018-B018
Androgen-deprivation therapy (ADT) remains the gold-standard therapy for prostate cancer (PrCa), and although ADT is initially effective, most men progress to castrate-resistant prostate cancer (CRPC) within 2-3 years. Advanced CRPC is challenging to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ccf6efc4dfdbd993437b8a21b2410ef
https://doi.org/10.1158/1538-7445.prca2017-b018
https://doi.org/10.1158/1538-7445.prca2017-b018
Publikováno v:
Hypertension in Pregnancy. 27:169-181
Preeclampsia is characterised by an abnormal vascular response to placentation and is associated with increased systemic vascular resistance and endothelial cell dysfunction. This study investigated the mRNA and protein expression of the beta(2) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b76954d770fff654176a3fe94c1007c
https://doi.org/10.1080/10641950701826554
https://doi.org/10.1080/10641950701826554
Autor:
Michael L. Beshiri, Holly M. Nguyen, Caitlyn Fuller, Shelley K. Hoover, Aian Neil Alilin, Juan Juan Yin, R. Mark Simpson, Xiaohu Zhang, Lauren E. Stahl, Eva Corey, Lei Fang, Supreet Agarwal, Craig J. Thomas, Crystal Tran, John K. Simmons, Rajarshi Guha, David A. Proia, Jacob Cawley, Keith H. Jansson, Paul G. Hynes, Ross Lake, Kathleen Kelly, John B. Tucker
Publikováno v:
Cancer Research. 77:3065-3065
Castrate resistant prostate cancer (CRPC) remains the primary cause of mortality for prostate cancer (PCa) patients. Several therapies are currently approved for use against CRPC, consisting mostly of androgen receptor (AR) signaling inhibitors and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18a13866f94b6135d197ad3ad5ab672a
https://doi.org/10.1158/1538-7445.am2017-3065
https://doi.org/10.1158/1538-7445.am2017-3065
Autor:
Yen Nien Liu, Paul G. Hynes, Wei Yu Chen, Ben Barrett, Jiaoti Huang, Lei Fang, Wassim Abou-Kheir, Orla Casey, Florent Suau, Man Kit Siu, Yao Yu Hsieh, Juan Juan Yin, Yung Sheng Chang, Kathleen Kelly
Publikováno v:
Oncotarget
// Man Kit Siu 1,2,* , Wassim Abou-Kheir 3,* , Juan Juan Yin 4,* , Yung-Sheng Chang 1 , Ben Barrett 4 , Florent Suau 4 , Orla Casey 4 , Wei-Yu Chen 5 , Lei Fang 4 , Paul Hynes 4 , Yao-Yu Hsieh 1,6 ,Yen-Nien Liu 1,7 , Jiaoti Huang 8 and Kathleen Kelly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee9892318dfdadcd091643f496b6aa0
https://pubmed.ncbi.nlm.nih.gov/30190798
https://pubmed.ncbi.nlm.nih.gov/30190798