Zobrazeno 1 - 10
of 389
pro vyhledávání: '"Paul G Horgan"'
Autor:
Kathryn AF Pennel, Jean A Quinn, Colin Nixon, Jitwadee Inthagard, Hester C vanWyk, David Chang, Selma Rebus, GPOL Group, Jennifer Hay, Noori N Maka, Campbell SD Roxburgh, Paul G Horgan, Donald C McMillan, James H Park, Antonia K Roseweir, Colin W Steele, Joanne Edwards
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 8, Iss 6, Pp 509-520 (2022)
Abstract CXCL8 is an inflammatory chemokine elevated in the colorectal cancer (CRC) tumour microenvironment. CXCR2, the major receptor for CXCL8, is predominantly expressed by neutrophils. In the cancer setting, CXCL8 plays important roles in neutrop
Externí odkaz:
https://doaj.org/article/2587601ff4f442529788ab8eca02bcc0
Autor:
Sara SF Al‐Badran, Lauren Grant, Maejoy V Campo, Jitwadee Inthagard, Kathryn Pennel, Jean Quinn, Prakash Konanahalli, Liam Hayman, Paul G Horgan, Donald C McMillan, Campbell SD Roxburgh, Antonia Roseweir, James H Park, Joanne Edwards
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 7, Iss 2, Pp 121-134 (2021)
Abstract The tumour microenvironment is an important factor for colorectal cancer prognosis, affecting the patient's immune response. Immune checkpoints, which regulate the immune functions of lymphocytes, may provide prognostic power. This study aim
Externí odkaz:
https://doaj.org/article/a3ff5f9d8dbd4c0faf511ffc1822eba4
Autor:
Antonia K Roseweir, James H Park, Sanne ten Hoorn, Arfon GMT Powell, Susan Aherne, Campbell SD Roxburgh, Donald C McMillan, Paul G Horgan, Elizabeth Ryan, Kieran Sheahan, Louis Vermeulen, James Paul, Andrea Harkin, Janet Graham, Owen Sansom, David N Church, Ian Tomlinson, Mark Saunders, Tim J Iveson, Joanne Edwards
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 6, Iss 4, Pp 283-296 (2020)
Abstract Histological ‘phenotypic subtypes’ that classify patients into four groups (immune, canonical, latent and stromal) have previously been demonstrated to stratify survival in a stage I–III colorectal cancer (CRC) pilot cohort. However, c
Externí odkaz:
https://doaj.org/article/86ccccce88334b4890153382c13043e0
Autor:
James H Park, Hester vanWyk, Donald C McMillan, Joanne Edwards, Clare Orange, Paul G Horgan, Campbell SD Roxburgh
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 6, Iss 1, Pp 30-39 (2020)
Abstract The tumour microenvironment (TME) is recognised as an important prognostic characteristic and therapeutic target in patients with colorectal cancer (CRC). However, assessment generally utilises surgically resected specimens, precluding neoad
Externí odkaz:
https://doaj.org/article/c1342cf94ded4478ac0b433deac124ee
Autor:
Aliah M Alhayyan, Stephen T McSorley, Rachel J Kearns, Paul G Horgan, Campbell S D Roxburgh, Donald C McMillan
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0228580 (2020)
BACKGROUND/AIM:The magnitude of the postoperative systemic inflammatory response (SIR) is now recognised to be associated with both short and long-term outcomes in patients undergoing surgery for colon cancer. During such surgery, it is unclear wheth
Externí odkaz:
https://doaj.org/article/12b14fc7cd3343bbbb7dbff55ae5333c
Autor:
Allan M. Golder, Michael Ferguson, Paul McMillan, David Mansouri, Paul G. Horgan, Campbell S. Roxburgh, Ross D. Dolan, Josh McGovern, Donald C. McMillan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Low skeletal muscle index/density (SMI/SMD) is prevalent in cancer, adversely prognostic and associated with tumour stage and the systemic inflammatory response (SIR). Age and SMI/SMD has not been widely studied. The present study analyses t
Externí odkaz:
https://doaj.org/article/7738b8cc6df943eaa536a0fe19246477
Autor:
Norman J. Galbraith, Jean A. Quinn, Sara Sf Al-Badran, Kathryn A.F. Pennel, Lily V.S. Hillson, Phimmada Hatthakarnkul, Molly McKenzie, Noori Maka, Lynette Loi, Mikaela Frixou, Colin W. Steele, Campbell S. Roxburgh, Paul G. Horgan, Donald C. McMillan, Joanne Edwards
Publikováno v:
Translational Oncology, Vol 48, Iss , Pp 102064- (2024)
Background: Transforming growth factor β-activated protein kinase-1 (TAK1) plays an important role in MAPK and NFκB pathways and has been associated with colorectal cancer. The aim of this study was to determine how cytoplasmic and juxtanuclear pun
Externí odkaz:
https://doaj.org/article/f77b384652bb4325a5076d3ce2c361b8
Autor:
Kathryn A. F. Pennel, Phimmada Hatthakarnkul, Colin S. Wood, Guang-Yu Lian, Sara S. F. Al-Badran, Jean A. Quinn, Assya Legrini, Jitwadee Inthagard, Peter G. Alexander, Hester van Wyk, Ahmad Kurniawan, Umar Hashmi, Michael A. Gillespie, Megan Mills, Aula Ammar, Jennifer Hay, Ditte Andersen, Colin Nixon, Selma Rebus, David K. Chang, Caroline Kelly, Andrea Harkin, Janet Graham, David Church, Ian Tomlinson, Mark Saunders, Tim Iveson, Tamsin R. M. Lannagan, Rene Jackstadt, Noori Maka, Paul G. Horgan, Campbell S. D. Roxburgh, Owen J. Sansom, Donald C. McMillan, Colin W. Steele, Nigel B. Jamieson, James H. Park, Antonia K. Roseweir, Joanne Edwards
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-20 (2024)
Abstract Colorectal cancer (CRC) is a heterogenous malignancy underpinned by dysregulation of cellular signaling pathways. Previous literature has implicated aberrant JAK/STAT3 signal transduction in the development and progression of solid tumors. I
Externí odkaz:
https://doaj.org/article/3b63169b435447a19a5fb490ee037279
Autor:
Josh McGovern, Charles Mackay, Rhiannon Freireich, Allan M. Golder, Ross D. Dolan, Paul G. Horgan, David Holroyd, Nigel B. Jamieson, Donald C. McMillan
Publikováno v:
Tomography, Vol 10, Iss 3, Pp 349-359 (2024)
Introduction: The prognostic value of CT-derived liver volume in terms of cancer outcomes is not clear. The aim of the present study was to examine the relationship between liver area on a single axial CT-slice and the total liver volume in patients
Externí odkaz:
https://doaj.org/article/517953092bdb4749bad6d194579ffdb4
Autor:
Michael J Proctor, Donald C McMillan, Paul G Horgan, Colin D Fletcher, Dinesh Talwar, David S Morrison
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0116206 (2015)
Markers of the systemic inflammatory response, including C-reactive protein and albumin (combined to form the modified Glasgow Prognostic Score), as well as neutrophil, lymphocyte and platelet counts have been shown to be prognostic of survival in pa
Externí odkaz:
https://doaj.org/article/438489bb38ad48db8ba894cd51e3b436