Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Paul G Higgs"'
Autor:
Pouyan Chamanian, Paul G Higgs
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 8, p e1010458 (2022)
We present simulations of non-enzymatic template-directed RNA synthesis that incorporate primer extension, ligation, melting, and reannealing. Strand growth occurs over multiple heating/cooling cycles, producing strands of several hundred nucleotides
Externí odkaz:
https://doaj.org/article/70996aaf35084e4e9ba316940dd04290
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205202 (2018)
We consider competition between antibiotic producing bacteria, non-producers (or cheaters), and sensitive cells in a two-dimensional lattice model. Previous work has shown that these three cell types can survive in spatial models due to the presence
Externí odkaz:
https://doaj.org/article/a43ca136af204a6bac19b1ce73206b9d
Autor:
Ye Eun Kim, Paul G Higgs
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 11, p e1005161 (2016)
It is believed that life passed through an RNA World stage in which replication was sustained by catalytic RNAs (ribozymes). The two most obvious types of ribozymes are a polymerase, which uses a neighbouring strand as a template to make a complement
Externí odkaz:
https://doaj.org/article/3cac0946231c4ed2b38e121f5e87066f
Autor:
Wenqi Ran, Paul G Higgs
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51652 (2012)
Among bacteria, we have previously shown that species that are capable of rapid growth have stronger selection on codon usage than slow growing species, and possess higher numbers of rRNA and tRNA genes. This suggests that fast-growers are adapted fo
Externí odkaz:
https://doaj.org/article/1a2179157f9344a8ab4842d57c87daca
Autor:
Hyunjin Park, Paul G. Higgs
Publikováno v:
Viruses, Vol 16, Iss 7, p 1081 (2024)
Plus, minus, and double-strand RNA viruses are all found in nature. We use computational models to study the relative success of these strategies. We consider translation, replication, and virion assembly inside one cell, and transmission of virions
Externí odkaz:
https://doaj.org/article/753e54b1adc442349c605bdc6c897731
Publikováno v:
Viruses, Vol 15, Iss 5, p 1135 (2023)
RNA viruses may be monopartite (all genes on one strand), multipartite (two or more strands packaged separately) or segmented (two or more strands packaged together). In this article, we consider competition between a complete monopartite virus, A, a
Externí odkaz:
https://doaj.org/article/ffb3d8de5a524c72a5968021d94628ba
Publikováno v:
Life, Vol 12, Iss 9, p 1373 (2022)
The rolling circle mechanism found in viroids and some RNA viruses is a likely way that replication could have begun in the RNA World. Here, we consider simulations of populations of protocells, each containing multiple copies of rolling circle RNAs
Externí odkaz:
https://doaj.org/article/377dd7b4783e41ebaac2e361c66cef52
Autor:
Teresa K. Attwood, Paul G. Higgs and
Publikováno v:
Bioinformatics and Molecular Evolution ISBN: 9781118697078
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d8d29b4cbc5027cccc22ae959eb0011
https://doi.org/10.1002/9781118697078.ch8
https://doi.org/10.1002/9781118697078.ch8
Autor:
Paul G. Higgs, Teresa K. Attwood
Publikováno v:
Bioinformatics and Molecular Evolution ISBN: 9781118697078
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::702ba8dc777c6d2e07b2f7b13549fca3
https://doi.org/10.1002/9781118697078.ch12
https://doi.org/10.1002/9781118697078.ch12