Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Paul G, Weightman Potter"'
Autor:
Ana M. Cruz, Katie M. Partridge, Yasaman Malekizadeh, Julia M. Vlachaki Walker, Paul G. Weightman Potter, Katherine R. Pye, Simon J. Shaw, Kate L. J. Ellacott, Craig Beall
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
AimWe evaluated the efficacy of a novel brain permeable “metformin-like” AMP-activated protein kinase activator, R481, in regulating glucose homeostasis.Materials and MethodsWe used glucose sensing hypothalamic GT1-7 neuronal cells and pancreatic
Externí odkaz:
https://doaj.org/article/f44879889ae04371b5abf856270d301a
Publikováno v:
Cells, Vol 11, Iss 21, p 3422 (2022)
Astrocytes contribute to glutamatergic signalling, which is required for hypoglycaemia counterregulation and is impaired by recurrent insulin-induced hypoglycaemia. This study examined the glutamate response of astrocytes when challenged with acute a
Externí odkaz:
https://doaj.org/article/29126711bddc4d2ab8c82c6d26c8075c
Autor:
Paul G. Weightman Potter, Sam J. Washer, Aaron R. Jeffries, Janet E. Holley, Nick J. Gutowski, Emma L. Dempster, Craig Beall
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Aims/hypothesisRecurrent hypoglycaemia (RH) is a major side-effect of intensive insulin therapy for people with diabetes. Changes in hypoglycaemia sensing by the brain contribute to the development of impaired counterregulatory responses to and aware
Externí odkaz:
https://doaj.org/article/c6c89ae5c7d94de0afbfc6a623caeb02
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::344a5f606929af56810b013d43bc7aa5
https://doi.org/10.1530/endoabs.77.p182
https://doi.org/10.1530/endoabs.77.p182
Autor:
Craig Beall, Sam J. Washer, Aaron R. Jeffries, Emma Dempster, Paul G. Weightman Potter, Janet E. Holley, Nick J. Gutowski
Publikováno v:
Frontiers in Endocrinology
Frontiers in Endocrinology, Vol 12 (2021)
Frontiers in Endocrinology, Vol 12 (2021)
Aims/hypothesisRecurrent hypoglycaemia (RH) is a major side-effect of intensive insulin therapy for people with diabetes. Changes in hypoglycaemia sensing by the brain contribute to the development of impaired counterregulatory responses to and aware
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6689ed3df1151a1131dc1d61708f34a3
https://pubmed.ncbi.nlm.nih.gov/34122346
https://pubmed.ncbi.nlm.nih.gov/34122346
Autor:
Andrew D. Randall, Julia M. Vlachaki Walker, Craig Beall, Josephine L. Robb, John K. Chilton, Paul G. Weightman Potter, Kate L. J. Ellacott, Ritchie Williamson
Publikováno v:
Diabetologia
Aims/hypothesis Hypoglycaemia is a major barrier to good glucose control in type 1 diabetes. Frequent hypoglycaemic episodes impair awareness of subsequent hypoglycaemic bouts. Neural changes underpinning awareness of hypoglycaemia are poorly defined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de9f515f41de860cc60f7c877fd70409
http://europepmc.org/articles/PMC6290858
http://europepmc.org/articles/PMC6290858
Autor:
Amrinder Malhi, Craig Beall, Ana M Cruz, Julia M. Vlachaki Walker, Kate L. J. Ellacott, Michael L.J. Ashford, Paul G. Weightman Potter, Rory J. McCrimmon, Josephine L. Robb
Publikováno v:
Diabetes, Obesity and Metabolism. 19:997-1005
Aim To test the hypothesis that, given the role of AMP-activated protein kinase (AMPK) in regulating intracellular ATP levels, AMPK may alter ATP release from astrocytes, the main sources of extracellular ATP (eATP) within the brain. Materials and Me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4258faaaf79de52a21afd41535e5e541
https://doi.org/10.1111/dom.12912
https://doi.org/10.1111/dom.12912
Autor:
Paul G. Weightman Potter, Kate L. J. Ellacott, John K. Chilton, Josephine L. Robb, Nadia A. Hammad, Craig Beall
Publikováno v:
GliaREFERENCES. 68(11)
Inflammation and metabolism are intrinsically linked with inflammatory stimuli inducing metabolic changes in cells and, in turn, metabolic capacity determining cellular inflammatory responses. Although well characterized in peripheral immune cells th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b31e311e70b78ea907571da5a60deda1
https://pubmed.ncbi.nlm.nih.gov/32277522
https://pubmed.ncbi.nlm.nih.gov/32277522
Autor:
Hannah E. Smithers, Nicole A. Morrissey, Paul G. Weightman Potter, Josephine L. Robb, Kate L. J. Ellacott, Craig Beall
Publikováno v:
Neuroscience
Graphical abstract
Highlights • Glia direct respond to changes in nutrients and hormones regulating energy balance. • Microglia and astrocytes are implicated in the pathophysiology of obesity and diabetes. • Obesity causes gliosis: reversi
Highlights • Glia direct respond to changes in nutrients and hormones regulating energy balance. • Microglia and astrocytes are implicated in the pathophysiology of obesity and diabetes. • Obesity causes gliosis: reversi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3659b81b380fbc7b05a2be99245fe15c
https://pubmed.ncbi.nlm.nih.gov/31765625
https://pubmed.ncbi.nlm.nih.gov/31765625
Publikováno v:
Diabetes. 68
Astrocytes are important regulatory cells in the brain that support neuronal function. However, their role in hypoglycemia counterregulation is poorly understood. Moreover, astrocytic transcriptional responses to hypoglycemia and the mechanisms by wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6183557b027d212a12939beb7be77a8
https://doi.org/10.2337/db19-401-p
https://doi.org/10.2337/db19-401-p