Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Paul G, Higgs"'
Autor:
Hyunjin Park, Paul G. Higgs
Publikováno v:
Viruses, Vol 16, Iss 7, p 1081 (2024)
Plus, minus, and double-strand RNA viruses are all found in nature. We use computational models to study the relative success of these strategies. We consider translation, replication, and virion assembly inside one cell, and transmission of virions
Externí odkaz:
https://doaj.org/article/753e54b1adc442349c605bdc6c897731
Autor:
Pouyan Chamanian, Paul G Higgs
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 8, p e1010458 (2022)
We present simulations of non-enzymatic template-directed RNA synthesis that incorporate primer extension, ligation, melting, and reannealing. Strand growth occurs over multiple heating/cooling cycles, producing strands of several hundred nucleotides
Externí odkaz:
https://doaj.org/article/70996aaf35084e4e9ba316940dd04290
Publikováno v:
Viruses, Vol 15, Iss 5, p 1135 (2023)
RNA viruses may be monopartite (all genes on one strand), multipartite (two or more strands packaged separately) or segmented (two or more strands packaged together). In this article, we consider competition between a complete monopartite virus, A, a
Externí odkaz:
https://doaj.org/article/ffb3d8de5a524c72a5968021d94628ba
Publikováno v:
Life, Vol 12, Iss 9, p 1373 (2022)
The rolling circle mechanism found in viroids and some RNA viruses is a likely way that replication could have begun in the RNA World. Here, we consider simulations of populations of protocells, each containing multiple copies of rolling circle RNAs
Externí odkaz:
https://doaj.org/article/377dd7b4783e41ebaac2e361c66cef52
Autor:
Paul G. Higgs
Publikováno v:
Life, Vol 11, Iss 9, p 966 (2021)
With the aim of better understanding the nature of metabolism in the first cells and the relationship between the origin of life and the origin of metabolism, we propose three criteria that a chemical reaction system must satisfy in order to constitu
Externí odkaz:
https://doaj.org/article/9482609479e140d88b2a7806df276def
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205202 (2018)
We consider competition between antibiotic producing bacteria, non-producers (or cheaters), and sensitive cells in a two-dimensional lattice model. Previous work has shown that these three cell types can survive in spatial models due to the presence
Externí odkaz:
https://doaj.org/article/a43ca136af204a6bac19b1ce73206b9d
Publikováno v:
Life, Vol 9, Iss 3, p 65 (2019)
In RNA-World scenarios for the origin of life, replication is catalyzed by polymerase ribozymes. Replicating RNA systems are subject to invasion by non-functional parasitic strands. It is well-known that there are two ways to avoid the destruction of
Externí odkaz:
https://doaj.org/article/5c2467eb1b594e46a781618dbc9bf965
Autor:
Ye Eun Kim, Paul G Higgs
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 11, p e1005161 (2016)
It is believed that life passed through an RNA World stage in which replication was sustained by catalytic RNAs (ribozymes). The two most obvious types of ribozymes are a polymerase, which uses a neighbouring strand as a template to make a complement
Externí odkaz:
https://doaj.org/article/3cac0946231c4ed2b38e121f5e87066f
Publikováno v:
Evolutionary Bioinformatics, Vol 3, Pp 1-13 (2007)
Many different selective effects on DNA and proteins influence the frequency of codons and amino acids in coding sequences. Selection is often stronger on highly expressed genes. Hence, by comparing high- and low-expression genes it is possible to di
Externí odkaz:
https://doaj.org/article/8ac8af6b51c94973b6f7599ac754f644
Publikováno v:
Life, Vol 7, Iss 4, p 41 (2017)
Biological RNA is a uniform polymer in three senses: it uses nucleotides of a single chirality; it uses only ribose sugars and four nucleobases rather than a mixture of other sugars and bases; and it uses only 3′-5′ bonds rather than a mixture of
Externí odkaz:
https://doaj.org/article/4a7fedced15e4c6896c722026e0f5b68