Zobrazeno 1 - 10
of 171
pro vyhledávání: '"Paul G, Higgs"'
Autor:
Dacks, Joel B
Publikováno v:
The Quarterly Review of Biology, 2005 Dec . 80(4), 471-472.
Externí odkaz:
https://www.jstor.org/stable/10.1086/501259
Autor:
Hyunjin Park, Paul G. Higgs
Publikováno v:
Viruses, Vol 16, Iss 7, p 1081 (2024)
Plus, minus, and double-strand RNA viruses are all found in nature. We use computational models to study the relative success of these strategies. We consider translation, replication, and virion assembly inside one cell, and transmission of virions
Externí odkaz:
https://doaj.org/article/753e54b1adc442349c605bdc6c897731
Autor:
Pouyan Chamanian, Paul G Higgs
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 8, p e1010458 (2022)
We present simulations of non-enzymatic template-directed RNA synthesis that incorporate primer extension, ligation, melting, and reannealing. Strand growth occurs over multiple heating/cooling cycles, producing strands of several hundred nucleotides
Externí odkaz:
https://doaj.org/article/70996aaf35084e4e9ba316940dd04290
Publikováno v:
Viruses, Vol 15, Iss 5, p 1135 (2023)
RNA viruses may be monopartite (all genes on one strand), multipartite (two or more strands packaged separately) or segmented (two or more strands packaged together). In this article, we consider competition between a complete monopartite virus, A, a
Externí odkaz:
https://doaj.org/article/ffb3d8de5a524c72a5968021d94628ba
Autor:
Joel B Dacks
Publikováno v:
The Quarterly Review of Biology. 80:471-472
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c31be9339e42169b04b68ab9c27ce05
https://doi.org/10.1086/501259
https://doi.org/10.1086/501259
Publikováno v:
Life, Vol 12, Iss 9, p 1373 (2022)
The rolling circle mechanism found in viroids and some RNA viruses is a likely way that replication could have begun in the RNA World. Here, we consider simulations of populations of protocells, each containing multiple copies of rolling circle RNAs
Externí odkaz:
https://doaj.org/article/377dd7b4783e41ebaac2e361c66cef52
Autor:
Paul G. Higgs
Publikováno v:
Life, Vol 11, Iss 9, p 966 (2021)
With the aim of better understanding the nature of metabolism in the first cells and the relationship between the origin of life and the origin of metabolism, we propose three criteria that a chemical reaction system must satisfy in order to constitu
Externí odkaz:
https://doaj.org/article/9482609479e140d88b2a7806df276def
Autor:
Counsell, Damian
Publikováno v:
Comparative and Functional Genomics; July 2005, Vol. 6 Issue: 5-6 p317-319, 3p
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205202 (2018)
We consider competition between antibiotic producing bacteria, non-producers (or cheaters), and sensitive cells in a two-dimensional lattice model. Previous work has shown that these three cell types can survive in spatial models due to the presence
Externí odkaz:
https://doaj.org/article/a43ca136af204a6bac19b1ce73206b9d
Publikováno v:
Life, Vol 9, Iss 3, p 65 (2019)
In RNA-World scenarios for the origin of life, replication is catalyzed by polymerase ribozymes. Replicating RNA systems are subject to invasion by non-functional parasitic strands. It is well-known that there are two ways to avoid the destruction of
Externí odkaz:
https://doaj.org/article/5c2467eb1b594e46a781618dbc9bf965