Výsledky vyhledávání - "Paul F.K. Wackers"

Relevance of In Vitro Transcriptomics for In Vivo Mode of Action Assessment

Autor: Harm J. Heusinkveld, Emiel Rorije, Paul F.K. Wackers, Jeroen L. A. Pennings, Mirjam Luijten

Publikováno v: Chemical Research in Toxicology. 34:452-459

Recently, we reported an in vitro toxicogenomics comparison approach to categorize chemical substances according to similarities in their proposed toxicological modes of action. Use of such an approach for regulatory purposes requires, among others,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d63b0e49e634e14e006826f4000cefd
https://doi.org/10.1021/acs.chemrestox.0c00313

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Neuronal Differentiation Pathways and Compound-Induced Developmental Neurotoxicity in the Human Neural Progenitor Cell Test (Hnpt) Revealed by Rna-Seq

Autor: Victoria C. de Leeuw, Conny T.M. van Oostrom, Paul F.K. Wackers, Jeroen L.A. Pennings, Hennie M. Hodemaekers, Aldert H. Piersma, Ellen V.S. Hessel

Publikováno v: Chemosphere

There is an increased awareness that the use of animals for compound-induced developmental neurotoxicity (DNT) testing has limitations. Animal-free innovations, especially the ones based on human stem cell-based models are pivotal in studying DNT sin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf8f254f07ba555a318f5bf3ac5fa3b
https://doi.org/10.2139/ssrn.4048728

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The effects of bariatric surgery on clinical profile, DNA methylation, and ageing in severely obese patients

Autor: Vincent W. Bloks, Ana B. Crujeiras, Eliza Fraszczyk, Mirjam Luijten, Jan Greve, Sander S. Rensen, Paul F.K. Wackers, Annemieke M.W. Spijkerman, Wim A. Buurman, Harold Snieder, Jana V. van Vliet-Ostaptchouk, Carla Barbosa Nonino, Carolina Ferreira Nicoletti, Bruce H. R. Wolffenbuttel

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Clinical Epigenetics
Clinical epigenetics, 12(1):14. BioMed Central Ltd
Clinical Epigenetics, 12(1):14. BMC

Background Severe obesity is a growing, worldwide burden and conventional therapies including radical change of diet and/or increased physical activity have limited results. Bariatric surgery has been proposed as an alternative therapy showing promis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18758fd625e0c55359ce138d0b7d7654

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Benchtop NMR spectroscopy in the analysis of substandard and falsified medicines as well as illegal drugs

Autor: Amy van Beers, Peter H. J. Keizers, Eva van der Aa, Frank Bakker, José Ferreira, Dion van Kollenburg, Paul F.K. Wackers

Substandard and falsified medical products may cause harm to patients and fail to treat the diseases or conditions for which they were intended. It is therefore required to have analytical methods available to assess medical product quality. Benchtop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4210bbffa70046fb429f085f4110b30a
http://hdl.handle.net/10029/623533

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Differential effects of fluoxetine and venlafaxine in the neural embryonic stem cell test (ESTn) revealed by a cell lineage map

Autor: Conny T. M. van Oostrom, Paul F.K. Wackers, Ellen V.S. Hessel, Hennie M. Hodemaekers, Jeroen L. A. Pennings, Aldert H. Piersma, Victoria C. de Leeuw

Publikováno v: Neurotoxicology. 76

There is a need for in vitro tests for the evaluation of chemicals and pharmaceuticals that may cause developmental neurotoxicity (DNT) in humans. The neural embryonic stem cell test (ESTn) is such an in vitro test that mimics early neural differenti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc04bd4aa2d2c0c4f7a2a71a345b2bc
https://pubmed.ncbi.nlm.nih.gov/31593710

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Time-restricted feeding improves adaptation to chronically alternating light-dark cycles

Autor: Rosa van den Berg, Conny T. M. van Oostrom, Martijn E.T. Dollé, Till Roenneberg, Tom Deboer, Linda W. M. van Kerkhof, Lauren L. Tambyrajah, Gerben Hulsegge, Maaike Schilperoort, Nienke R. Biermasz, Karin I. Proper, Karina Wagner, Harry van Steeg, Sander Kooijman, Paul F.K. Wackers, Patrick C.N. Rensen

Publikováno v: Scientific Reports
Scientific Reports, 9(1):7874. Nature Publishing Group
Scientific Reports, 9
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)

Disturbance of the circadian clock has been associated with increased risk of cardio-metabolic disorders. Previous studies showed that optimal timing of food intake can improve metabolic health. We hypothesized that time-restricted feeding could be a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65887ef9e66de5c7177bf4caf39ab474
http://europepmc.org/articles/PMC6536683

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