Zobrazeno 1 - 10
of 243
pro vyhledávání: '"Paul F. Pilch"'
Publikováno v:
eLife, Vol 9 (2020)
It has been known adipocytes increase p53 expression and activity in obesity, however, only canonical p53 functions (i.e. senescence and apoptosis) are attributed to inflammation-associated metabolic phenotypes. Whether or not p53 is directly involve
Externí odkaz:
https://doaj.org/article/30023e18c2f04223bbd42a63b22d5f03
Autor:
Jamie J. L. Williams, Nasser Alotaiq, William Mullen, Richard Burchmore, Libin Liu, George S. Baillie, Fred Schaper, Paul F. Pilch, Timothy M. Palmer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
SOCS3 is an important negative feedback inhibitor of JAK–STAT-mediated cytokine signalling. Here the authors implicate cavin-1 — an essential component of caveolae — in the recruitment of SOCS3 to the plasma membrane to prevent sustained cytoki
Externí odkaz:
https://doaj.org/article/150955b131d248018bd4158e8688ea0e
Autor:
Mark P. Jedrychowski, Libin Liu, Collette J. Laflamme, Kalypso Karastergiou, Tova Meshulam, Shi-Ying Ding, Yuanyuan Wu, Mi-Jeong Lee, Steven P. Gygi, Susan K. Fried, Paul F. Pilch
Publikováno v:
Molecular Metabolism, Vol 4, Iss 11, Pp 758-770 (2015)
Objective: Adipocytes are robust protein secretors, most notably of adipokines, hormone-like polypeptides, which act in an endocrine and paracrine fashion to affect numerous physiological processes such as energy balance and insulin sensitivity. To u
Externí odkaz:
https://doaj.org/article/a3dc06a4d9be427492c6dea1f64ccac4
Autor:
Manuel A. Fernández-Rojo, Milena Gongora, Rebecca L. Fitzsimmons, Nick Martel, Sheree D. Martin, Susan J. Nixon, Andrew J. Brooks, Maria P. Ikonomopoulou, Sally Martin, Harriet P. Lo, Stephen A. Myers, Christina Restall, Charles Ferguson, Paul F. Pilch, Sean L. McGee, Robin L. Anderson, Michael J. Waters, John F. Hancock, Sean M. Grimmond, George E.O. Muscat, Robert G. Parton
Publikováno v:
Cell Reports, Vol 4, Iss 2, Pp 238-247 (2013)
Caveolae and caveolin-1 (CAV1) have been linked to several cellular functions. However, a model explaining their roles in mammalian tissues in vivo is lacking. Unbiased expression profiling in several tissues and cell types identified lipid metabolis
Externí odkaz:
https://doaj.org/article/626b24aa557c4a558809186d6302745e
Autor:
Libin Liu, Paul F Pilch
Publikováno v:
eLife, Vol 5 (2016)
Ribosomal RNA transcription mediated by RNA polymerase I represents the rate-limiting step in ribosome biogenesis. In eukaryotic cells, nutrients and growth factors regulate ribosomal RNA transcription through various key factors coupled to cell grow
Externí odkaz:
https://doaj.org/article/c02e0f647a294bd89bf7b24b3a545135
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 8, Pp 1526-1532 (2011)
Mice and humans lacking functional caveolae are dyslipidemic and have reduced fat stores and smaller fat cells. To test the role of caveolins/caveolae in maintaining lipid stores and adipocyte integrity, we compared lipolysis in caveolin-1 (Cav1)-nul
Externí odkaz:
https://doaj.org/article/730a3f1e42c24a76a48e88a827b3f392
Autor:
Erica L. Scheller, Casey R. Doucette, Brian S. Learman, William P. Cawthorn, Shaima Khandaker, Benjamin Schell, Brent Wu, Shi-Ying Ding, Miriam A. Bredella, Pouneh K. Fazeli, Basma Khoury, Karl J. Jepsen, Paul F. Pilch, Anne Klibanski, Clifford J. Rosen, Ormond A. MacDougald
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-2 (2016)
Nature Communications 6: Article number: 7808 (2015); Published: 6 August 2015; Updated: 8 December 2016 In Figure 3 of this Article, marrow adipose tissue volumes (in panels b and c) and adipocyte numbers (in panel g) were calculated incorrectly. In
Externí odkaz:
https://doaj.org/article/e0abc6c23fb24082a78690bfbd85b5db
Autor:
Jeffrey R. Simard, Tova Meshulam, Biju K. Pillai, Michael T. Kirber, Kellen Brunaldi, Su Xu, Paul F. Pilch, James A. Hamilton
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 5, Pp 914-922 (2010)
Ectopic expression of caveolin-1 in HEK293 cells enhances FA sequestration in membranes as measured by a pH-sensitive fluorescent dye (1). We hypothesized that sequestration of FA is due to the enrichment of caveolin in the cytosolic leaflet and its
Externí odkaz:
https://doaj.org/article/1262d82de30b417b94bd7dccecea83a0
Autor:
Paul F. Pilch, Ricardo P. Souto, Libin Liu, Mark P. Jedrychowski, Eric A. Berg, Catherine E. Costello, Steven P. Gygi
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 10, Pp 2103-2111 (2007)
It has been known for decades that the adipocyte cell surface is particularly rich in small invaginations we now know to be caveolae. These structures are common to many cell types but are not ubiquitous. They have generated considerable curiosity, a
Externí odkaz:
https://doaj.org/article/83fedbc3a3a4431abae53e721354a479
Publikováno v:
J Biol Chem
Cavin-1/polymerase I and transcript release factor (PTRF) is a requisite component of caveolae, small plasma membrane invaginations that are highly abundant in adipocytes. Cavin-1 is a dynamic molecule whose dissociation from caveolae plays an import