Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Paul F. Jackson"'
Autor:
William Nguyen, Madeline G. Dans, Iain Currie, Jon Kyle Awalt, Brodie L. Bailey, Chris Lumb, Anna Ngo, Paola Favuzza, Josephine Palandri, Saishyam Ramesh, Jocelyn Penington, Kate E. Jarman, Partha Mukherjee, Arnish Chakraborty, Alexander G. Maier, Giel G. van Dooren, Tony Papenfuss, Sergio Wittlin, Alisje Churchyard, Jake Baum, Elizabeth A. Winzeler, Delphine Baud, Stephen Brand, Paul F. Jackson, Alan F. Cowman, Brad E. Sleebs
Publikováno v:
ACS Infectious Diseases. 9:668-691
Autor:
Trent D. Ashton, Madeline G. Dans, Paola Favuzza, Anna Ngo, Adele M. Lehane, Xinxin Zhang, Deyun Qiu, Bikash Chandra Maity, Nirupam De, Kyra A. Schindler, Tomas Yeo, Heekuk Park, Anne-Catrin Uhlemann, Alisje Churchyard, Jake Baum, David A. Fidock, Kate E. Jarman, Kym N. Lowes, Delphine Baud, Stephen Brand, Paul F. Jackson, Alan F. Cowman, Brad E. Sleebs
Publikováno v:
Journal of Medicinal Chemistry. 66:3540-3565
Entamoeba histolytica is a disease-causing parasitic amoeba which affects an estimated 50 million people worldwide, particularly in socioeconomically vulnerable populations experiencing water sanitation issues. Infection with E. histolytica is referr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7713cc7a704bb45c2ace9cefa4f8ec5a
https://doi.org/10.1101/2021.10.06.463301
https://doi.org/10.1101/2021.10.06.463301
Autor:
Francisco-Javier Gamo, William Nguyen, Benoît Laleu, Christopher D. Goodman, Danny W. Wilson, Kym N Lowes, Paul F. Jackson, Alan F. Cowman, Stephen Brand, Brodie L Bailey, Laura M. Sanz, Maria R. Gancheva, Brad E. Sleebs, Geoffrey I. McFadden, Anna Ngo, Paola Favuzza
Publikováno v:
Bioorganic Chemistry. 115:105244
Malaria is a devastating parasitic disease caused by parasites from the genus Plasmodium. Therapeutic resistance has been reported against all clinically available antimalarials, threatening our ability to control the disease and therefore there is a
Autor:
Ross S. Hall, Nghi Nguyen, Abdul Jabbar, Brad E. Sleebs, Bill C.H. Chang, Aya C Taki, Paul F. Jackson, Tao Wang, Robin B. Gasser, Joseph J. Byrne, Pasi K. Korhonen
Publikováno v:
Pharmaceuticals
Pharmaceuticals, Vol 14, Iss 616, p 616 (2021)
Volume 14
Issue 7
Pharmaceuticals, Vol 14, Iss 616, p 616 (2021)
Volume 14
Issue 7
Parasitic worms cause very significant diseases in animals and humans worldwide, and their control is critical to enhance health, well-being and productivity. Due to widespread drug resistance in many parasitic worms of animals globally, there is a m
Autor:
Paul F. Jackson, Christopher M. Flores, Antoinette MaassenVanDenBrink, Kristian Agmund Haanes, Kayi Y. Chan, Brian C. Shook, Jimmy Zhang, Alejandro Labastida-Ramírez, Alexander H. J. Danser, René de Vries, Carlos M. Villalón
Publikováno v:
Journal of Headache and Pain, 19:41. Springer-Verlag Italia
The Journal of Headache and Pain
The Journal of Headache and Pain, Vol 19, Iss 1, Pp 1-10 (2018)
The Journal of Headache and Pain
The Journal of Headache and Pain, Vol 19, Iss 1, Pp 1-10 (2018)
Background Migraine is considered a neurovascular disorder, but its pathophysiological mechanisms are not yet fully understood. Adenosine has been shown to increase in plasma during migraine attacks and to induce vasodilation in several blood vessels
Autor:
Tara Mezzasalma Haarlander, Karen Carroll, Sharon L. Burke, Shariff Bayoumy, Ingrid Christa Deckman, Cuifen Huo, Richard Alexander, Monica Singer, Matthew J. Todd, Yue-Mei Zhang, Kristi A. Leonard, Cindy Milligan, Robyn Williams, Kenneth J. Rhodes, Robert H. Scannevin, Keli Dzordzorme, John Spurlino, Brett A. Tounge, Diane M. Maguire, Paul F. Jackson, Celine Schalk-Hihi, Lawrence C. Kuo, Eric Devine, Frank A. Lewandowski
Publikováno v:
The Journal of biological chemistry. 292(43)
Aberrant activation of matrix metalloproteinases (MMPs) is a common feature of pathological cascades observed in diverse disorders, such as cancer, fibrosis, immune dysregulation, and neurodegenerative diseases. MMP-9, in particular, is highly dynami
Autor:
Stefan Steinbacher, Annie X. Liu, Paul F. Jackson, Marina I. Nelen, Marcos E. Milla, Krystal Herman, Aaron N. Patrick, Jonathan M. Blevitt, Paul J. Krawczuk, Kevin J. Lumb, Alec D. Lebsack, Taraneh Mirzadegan, Michael D. Hack
Publikováno v:
Journal of medicinal chemistry. 60(8)
A prevalent observation in high-throughput screening and drug discovery programs is the inhibition of protein function by small-molecule compound aggregation. Here, we present the X-ray structural description of aggregation-based inhibition of a prot
Autor:
Lori Westover, Nathaniel H. Wallace, Paul F. Jackson, Brian C. Shook, Lisa Lampron, Devraj Chakravarty, J. Kent Barbay, Mark T. Powell, Aihua Wang, Robert H. Scannevin, Kenneth J. Rhodes, Mark Ault, Vernon C. Alford, Jeffrey Crooke, Kristi A. Leonard, Stefanie Rassnick, Karen Carroll
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:2688-2691
A novel series of benzyl substituted thieno[2,3-d]pyrimidines were identified as potent A2A receptor antagonists. Several five- and six-membered heterocyclic replacements for the optimized methylfuran were explored. Select compounds effectively rever
Autor:
Devraj Chakravarty, Sandra Damon, Kenneth J. Rhodes, Mark Ault, Robert H. Scannevin, Lori Westover, Xun Li, Vernon C. Alford, Aihua Wang, Heng-Keang Lim, Lisa Lampron, Jeffrey Crooke, Scott Youells, Paul F. Jackson, Ronald K. Russell, J. Kent Barbay, Mark T. Powell, Stefanie Rassnick, Derek A. Beauchamp, Shawn Branum, Kenneth M. Wells, Kristi A. Leonard, Nathaniel H. Wallace, Karen Carroll, Brian C. Shook
Publikováno v:
Journal of Medicinal Chemistry. 55:1402-1417
The design and characterization of two, dual adenosine A2A/A1 receptor antagonists in several animal models of Parkinson's disease is described. Compound 1 was previously reported as a potential treatment for Parkinson's disease. Further characteriza