Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Paul F. Cliften"'
Publikováno v:
PPAR Research, Vol 2020 (2020)
Pioglitazone (Pio) is a thiazolidinedione (TZD) insulin-sensitizing drug whose effects result predominantly from its modulation of the transcriptional activity of peroxisome proliferator-activated-receptor-gamma (PPARγ). Pio is used to treat human i
Externí odkaz:
https://doaj.org/article/f37cfc18125c44bd8fa6a36b0962e2c7
Autor:
David A. Rudnick, Jiansheng Huang, Tunda Hidvegi, Andrew S. Chu, Pamela Hale, Admire Munanairi, Dennis J. Dietzen, Paul F. Cliften, Eric Tycksen, Andrew J. Lutkewitte, Brian N. Finck, Stephen C. Pak, Gary A. Silverman, David H. Perlmutter
Publikováno v:
Gastroenterology. 163(1)
Insulin signaling is known to regulate essential proteostasis mechanisms.The analyses here examined effects of insulin signaling in the PiZ mouse model of α1-antitrypsin deficiency in which hepatocellular accumulation and proteotoxicity of the misfo
Autor:
Elliott T. Klotz, Matthew C. Hibberd, Victoria Brown-Kennerly, Jeffrey I. Gordon, Richard D. Head, Andrew E. Schriefer, Lauren C. Burcea, Seth D. Crosby, Paul F. Cliften, Christopher S. Sawyer
Publikováno v:
Journal of Microbiological Methods. 154:6-13
Metagenomic sequencing of bacterial samples has become the gold standard for profiling microbial populations, but 16S rRNA profiling remains widely used due to advantages in sample throughput, cost, and sensitivity even though the approach is hampere
Autor:
Kathleen A. Silva, Simon W M John, Laura G. Reinholdt, Morgane Stum, Abigail L. D. Tadenev, Pak P. Poon, Robert W. Burgess, Christopher R. McMaster, Coleen Kane, Carolyn Ann Robinson, Kevin L. Seburn, Kathy E. Miers, John P. Sundberg, Paul F. Cliften
Publikováno v:
Genetics
The final step in proline biosynthesis is catalyzed by three pyrroline-5-carboxylate reductases, PYCR1, PYCR2, and PYCR3, which convert pyrroline-5-carboxylate (P5C) to proline. Mutations in human PYCR1 and ALDH18A1 (P5C Synthetase) cause Cutis Laxa
Autor:
Catherine G. Tran, Luis C. Borbon, Jacqueline L. Mudd, Ellen Abusada, Solmaz AghaAmiri, Sukhen C. Ghosh, Servando Hernandez Vargas, Guiying Li, Gabriella V. Beyer, Mary McDonough, Rachel Li, Carlos H.F. Chan, Susan A. Walsh, Thaddeus J. Wadas, Thomas O’Dorisio, M Sue O’Dorisio, Ramaswamy Govindan, Paul F. Cliften, Ali Azhdarinia, Andrew M. Bellizzi, Ryan C. Fields, James R. Howe, Po Hien Ear
Publikováno v:
Cancers; Volume 14; Issue 8; Pages: 1910
Gastroenteropancreatic neuroendocrine neoplasms (GEP NENs) are rare cancers consisting of neuroendocrine carcinomas (NECs) and neuroendocrine tumors (NETs), which have been increasing in incidence in recent years. Few cell lines and pre-clinical mode
Publikováno v:
Plant Physiology. 178:1436-1447
Insertional mutagenesis, in which a piece of exogenous DNA is integrated randomly into the genomic DNA of the recipient cell, is a useful method to generate new mutants with phenotypes of interest. The unicellular green alga Chlamydomonas reinhardtii
Publikováno v:
The American journal of surgical pathology. 43(5)
Salivary high-grade neuroendocrine carcinomas (NECs) are rare, occur predominantly in the parotid gland, and are difficult to differentiate from metastatic cutaneous Merkel cell carcinomas (MCCs), which have overlapping morphologic, immunophenotypic,
Autor:
Justin T. Brown, Mark R. Johnson, Leslie D. McIntosh, Christina M. Lockwood, David H. Spencer, Stephanie M. O’Guin, Mark A. Watson, Catherine E. Cottrell, John D. Pfeifer, Christopher S. Sawyer, Jacqueline E. Payton, Jennifer L. Stratman, Jeffrey Milbrandt, Eric J. Duncavage, Herbert W. Virgin, Rakesh Nagarajan, Andrew J. Bredemeyer, Paul F. Cliften, Ian S. Hagemann, Bijoy George, Karen Seibert, Shashikant Kulkarni, TuDung T. Nguyen, Hussam Al-Kateb, Dayna M. Oschwald, Robi D. Mitra, Savita Shrivastava, Dorie A. Sher, Lauren C. Burcea, Seth D. Crosby, Richard D. Head, Haley J. Abel
Publikováno v:
The Journal of Molecular Diagnostics. 16:89-105
Currently, oncology testing includes molecular studies and cytogenetic analysis to detect genetic aberrations of clinical significance. Next-generation sequencing (NGS) allows rapid analysis of multiple genes for clinically actionable somatic variant
Autor:
Steven A. Rosenberg, Jamie K. Teer, Colin A. Gross, Yong F. Li, Yardena Samuels, Mona El-Gamil, Paul F. Cliften, J. Lin, Jared J. Gartner, Yong-Chen Lu, Paul F. Robbins, Eric Tycksen
Publikováno v:
Nature medicine
Substantial regressions of metastatic lesions have been observed in up to 70% of patients with melanoma who received adoptively transferred autologous tumor-infiltrating lymphocytes (TILs) in phase 2 clinical trials. In addition, 40% of patients trea
Autor:
Jiansheng Huang, Sucha Sing, Andrew E. Schriefer, Paul F. Cliften, Sakil Kulkarni, Satdarshan P.S. Monga, David A. Rudnick, Dennis J. Dietzen
All serious liver injuries alter metabolism and initiate hepatic regeneration. Recent studies using partial hepatectomy (PH) and other experimental models of liver regeneration implicate the metabolic response to hepatic insufficiency as an important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a2aff631efb0768f55db6e65882bd3
https://europepmc.org/articles/PMC4816713/
https://europepmc.org/articles/PMC4816713/