Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Paul F. Chapman"'
Publikováno v:
Behavioural Pharmacology. 20:653-656
Impairments in reversal learning, which are commonly observed in patients with psychiatric disorders, remain difficult to treat. There is still a debate over the beneficial effects of cholinergic enhancers on improving behavioural flexibility. The ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5c79eca6e21556fecf91bdd66bbcbf
https://doi.org/10.1097/fbp.0b013e32832ec5bc
https://doi.org/10.1097/fbp.0b013e32832ec5bc
Autor:
Chiara Leoni, Cecilia Tiveron, Hans Welzl, Hans-Peter Lipp, Daniela Toniolo, Laura Pozzi, Flavia Valtorta, Andrea Menegon, Paul F. Chapman, Marina Raffaele di Barletta, Mark F. Ramsay, Stavros Papadimitriou, Simon G. Knevett, Patrizia D'Adamo, Laura Tatangelo, David P. Wolfer
Publikováno v:
Scopus-Elsevier
Non-specific mental retardation (NSMR) is a common human disorder characterized by mental handicap as the only clinical symptom. Among the recently identified MR genes is GDI1, which encodes alpha Gdi, one of the proteins controlling the activity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b763c5e2544ccaac77d77b8b3ec8714
https://doi.org/10.1093/hmg/11.21.2567
https://doi.org/10.1093/hmg/11.21.2567
Autor:
Annamaria Porrazzo, Riccardo Brambilla, Vincenzo Cestari, Jacques Pouysségur, Wojciech Krezel, Anne Marowsky, Stefania Fasano, Hans Welzl, Paul C. Orban, Chiara Vantaggiato, Alessandro Ciamei, Paul F. Chapman, Olga Valverde, Rafael Maldonado, Hans-Peter Lipp, Cristina Mazzucchelli, Pavel Pakhotin, Markus U. Ehrengruber, David P. Wolfer, Gilles Pagès
Publikováno v:
Neuron. 34:807-820
Extracellular signal-regulated kinases (ERK1 and 2) are synaptic signaling components necessary for several forms of learning. In mice lacking ERK1, we observe a dramatic enhancement of striatum-dependent long-term memory, which correlates with a fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::945018d1aefacb491206dea105ec1c83
https://doi.org/10.1016/s0896-6273(02)00716-x
https://doi.org/10.1016/s0896-6273(02)00716-x
Publikováno v:
Neuropharmacology. 37:581-592
Long-term potentiation was studied in vivo in the rat barrel cortex. It was found that LTP lasting several hours could be induced in layer II/III by tetanic stimuli applied in layer IV. The probability of inducing LTP at a given site was high (86%) p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ab0487c15f4daa47b768db4cd619e07
https://doi.org/10.1016/s0028-3908(98)00039-2
https://doi.org/10.1016/s0028-3908(98)00039-2
Autor:
Peter L. Malen, Paul F. Chapman
Publikováno v:
The Journal of Neuroscience. 17:2645-2651
Reports that nitric oxide synthase (NOS) inhibition prevents the induction of long-term potentiation (LTP) have been controversial. Recent evidence suggests that NO may help to regulate the threshold for LTP induction. We have tested this hypothesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97ecab67dce1e5dc6e8c5a88ba1dc35c
https://doi.org/10.1523/jneurosci.17-07-02645.1997
https://doi.org/10.1523/jneurosci.17-07-02645.1997
Publikováno v:
Neuron. 14:591-597
The alpha-Ca2+/calmodulin kinase II (alpha CaMKII) is required for long-term potentiation in the CA1 region of the hippocampus. Here, we report that this kinase also has a crucial role in presynaptic plasticity. Paired-pulse facilitation is blunted i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47e42801bb52c6d12ed0daa119f09d9
https://doi.org/10.1016/0896-6273(95)90315-1
https://doi.org/10.1016/0896-6273(95)90315-1
Autor:
Alcino J. Silva, Paul F. Chapman
Publikováno v:
Seminars in Neuroscience. 6:53-58
Techniques to derive mice with very specific mutations in any cloned gene are an exciting new addition to a series of impressive neuroscience tools that can be used to explore the connections between molecules, cells, circuits and behaving brains. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25c2d0640668912634bce507ee16f1c4
https://doi.org/10.1006/smns.1994.1007
https://doi.org/10.1006/smns.1994.1007
Autor:
Paul F. Chapman
Publikováno v:
Nature Neuroscience. 4:556-558
In contrast to the hippocampus, low-frequency stimulation in the amygdala produces synaptic enhancement via kainate receptors that spreads to inactive synapses on the same cell.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9952596a2ea7ba8052eda24f2e0689b
https://doi.org/10.1038/88367
https://doi.org/10.1038/88367
Publikováno v:
Europe PubMed Central
Nitric oxide (NO), an intercellular messenger in the central nervous system of vertebrates, plays an important role in the establishment of synaptic plasticity. In order to investigate the role of NO and synaptic plasticity in learning, we injected r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40980262211acd533861f73117564b03
https://doi.org/10.1097/00001756-199207000-00005
https://doi.org/10.1097/00001756-199207000-00005
Publikováno v:
Neuron. 8:211-216
Long-term potentiation is a long-lasting, use-dependent increase in the strength of synaptic connections. We investigated the role of nitric oxide (NO) in determining the duration of potentiation induced by high frequency stimulation of afferents in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f074467248c68227023105f88266624
https://doi.org/10.1016/0896-6273(92)90288-o
https://doi.org/10.1016/0896-6273(92)90288-o