Zobrazeno 1 - 10
of 182
pro vyhledávání: '"Paul F. Agris"'
Autor:
Brittany A. Elliott, Hsiang-Ting Ho, Srivathsan V. Ranganathan, Sweta Vangaveti, Olga Ilkayeva, Hala Abou Assi, Alex K. Choi, Paul F. Agris, Christopher L. Holley
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
The post-transcriptional modification of mRNAs provides an additional layer to gene expression regulation. Here the authors show that 2′-O-methylation mediated by box C/D snoRNAs and fibrillarin can inhibit the translation of target mRNAs.
Externí odkaz:
https://doaj.org/article/b5583f16311b4eff9351aede56bc09e1
Autor:
Amithi Narendran, Sweta Vangaveti, Srivathsan V. Ranganathan, Emily Eruysal, Miranda Craft, Omar Alrifai, Fu Yee Chua, Kathryn Sarachan, Breann Litwa, Sheetal Ramachandran, Paul F. Agris
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2021)
Human Genome Wide Association Studies found a significant risk of Type 2 Diabetes Mellitus (T2DM) in single nucleotide polymorphisms in the cdkal1 gene. The cdkal1 gene is remote from the insulin gene and with the surprising function of a specific tR
Externí odkaz:
https://doaj.org/article/7e2efb8a6d744d18a4c00bda6520c179
Publikováno v:
Antibiotics, Vol 10, Iss 1, p 41 (2021)
Combating single and multi-drug-resistant infections in the form of biofilms is an immediate challenge. The challenge is to discover innovative targets and develop novel chemistries that combat biofilms and drug-resistant organisms, and thwart emerge
Externí odkaz:
https://doaj.org/article/a9de368f256249be95202385f112ce7c
Publikováno v:
Biomolecules, Vol 7, Iss 1, p 29 (2017)
RNAs are central to all gene expression through the control of protein synthesis. Four major nucleosides, adenosine, guanosine, cytidine and uridine, compose RNAs and provide sequence variation, but are limited in contributions to structural variatio
Externí odkaz:
https://doaj.org/article/b4e07cdc49054ee98b37189aa434f8f2
Publikováno v:
The journal of physical chemistry. B. 126(6)
The 2-methylthio-modification (ms
Autor:
Valérie de Crécy-Lagard, Manal A. Swairjo, Jo Marie Bacusmo, Christopher Deutsch, Dirk Iwata-Reuyl, William Swinehart, Amit Luthra, Paul F. Agris, Kathryn L. Sarachan
Publikováno v:
RNA. 26:1094-1103
N6-threonylcarbamoyl adenosine (t6A) is a nucleoside modification found in all kingdoms of life at position 37 of tRNAs decoding ANN codons, which functions in part to restrict translation initiation to AUG and suppress frameshifting at tandem ANN co
Autor:
Sweta Vangaveti, Hasan DeMirci, Jessica L. Spears, Frank V. Murphy, William A. Cantara, Paul F. Agris, Kathryn L. Sarachan, Sri V. Ranganathan
Publikováno v:
J Mol Biol
Three of six arginine codons (CGU, CGC and CGA) are decoded by two Escherichia coli tRNA(Arg) isoacceptors. The anticodon stem and loop (ASL) domains of tRNA(Arg1) and tRNA(Arg2) both contain inosine and 2-methyladenosine modifications at positions 3
Autor:
Ebot S. Tabe, Zachary A. Kloos, Ryan Schneider, William A. Cantara, Janeen T. Bell, Paul F. Agris, Maria Basanta-Sanchez, Urenna J. Onwuanaibe, Caren J. Stark, Gabrielle C. Todd, Douglas B. Kitchen, Bryan C. Duffy, Ville Y. P. Väre, Kyla M. Frohlich, Spencer F. Weintraub, Kathleen A. McDonough
Publikováno v:
ChemMedChem. 14:758-769
The emergence of multidrug-resistant bacteria necessitates the identification of unique targets of intervention and compounds that inhibit their function. Gram-positive bacteria use a well-conserved tRNA-responsive transcriptional regulatory element
Autor:
Paul F. Agris, Sheetal Ramachandran, Miranda Craft, Sweta Vangaveti, Omar Alrifai, Kathryn L. Sarachan, Emily Eruysal, Amithi Narendran, Breann Litwa, Fu Yee Chua, Srivathsan V. Ranganathan
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2021)
Human Genome Wide Association Studies found a significant risk of Type 2 Diabetes Mellitus (T2DM) in single nucleotide polymorphisms in the cdkal1 gene. The cdkal1 gene is remote from the insulin gene and with the surprising function of a specific tR
Publikováno v:
Antibiotics
Antibiotics, Vol 10, Iss 41, p 41 (2021)
Antibiotics, Vol 10, Iss 41, p 41 (2021)
Combating single and multi-drug-resistant infections in the form of biofilms is an immediate challenge. The challenge is to discover innovative targets and develop novel chemistries that combat biofilms and drug-resistant organisms, and thwart emerge