The Gr64 cluster of gustatory receptors promotes survival and proteostasis of epithelial cells in Drosophila.

Autor: Michael E Baumgartner, Alex Mastrogiannopoulos, Iwo Kucinski, Paul F Langton, Eugenia Piddini

Publikováno v: PLoS Biology, Vol 20, Iss 7, p e3001710 (2022)

Gustatory Receptor 64 (Gr64) genes are a cluster of 6 neuronally expressed receptors involved in sweet taste sensation in Drosophila melanogaster. Gr64s modulate calcium signalling and excitatory responses to several different sugars. Here, we discov

Externí odkaz: https://doaj.org/article/4566caa47f404199853ee3a3653a5ebf

The PECAn image and statistical analysis pipeline identifies Minute cell competition genes and features

Autor: Michael E. Baumgartner, Paul F. Langton, Remi Logeay, Alex Mastrogiannopoulos, Anna Nilsson-Takeuchi, Iwo Kucinski, Jules Lavalou, Eugenia Piddini

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Abstract Investigating organ biology often requires methodologies to induce genetically distinct clones within a living tissue. However, the 3D nature of clones makes sample image analysis challenging and slow, limiting the amount of information that

Externí odkaz: https://doaj.org/article/b431140ebdbd4b4b8ccb044fce0d375a

Xrp1 and Irbp18 trigger a feed-forward loop of proteotoxic stress to induce the loser status

Autor: Logeay R, Paul F. Langton, Michael E. Baumgartner, Eugenia Piddini

Publikováno v: PLoS Genetics
PLoS Genetics, Vol 17, Iss 12, p e1009946 (2021)
Langton, P F, Baumgartner, M E, Logeay, R & Piddini, E 2021, ' Xrp1 and Irbp18 trigger a feed-forward loop of proteotoxic stress to induce the loser status ', PLoS Genetics, vol. 17, no. 2, e1009946 . https://doi.org/10.1371/journal.pgen.1009946

Cell competition induces the elimination of less-fit “loser” cells by fitter “winner” cells. In Drosophila, cells heterozygous mutant in ribosome genes, Rp/+, known as Minutes, are outcompeted by wild-type cells. Rp/+ cells display proteotoxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f75f23f1653f3ceae2faa11158283fff
http://europepmc.org/articles/PMC8675655

Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling

Autor: Lindsey L. Morris, Lawrence Banks, David Pim, Paul F. Langton, Amika Singla, Neil D. Pearson, Rebecca A. Faulkner, Kerrie E. McNally, Ezra Burstein, Chris M. Danson, Richard B. Sessions, Matthew Gallon, Rajesh Ghai, Brittany L. Overlee, Brett M. Collins, Heike Nägele, Imre Berger, Daniel D. Billadeau, Peter J. Cullen, Kate J. Heesom, Florian Steinberg

Publikováno v: McNally, K E, Faulkner, R, Steinberg, F, Gallon, M, Ghai, R, Pim, D, Langton, P, Pearson, N, Danson, C M, Nägele, H, Morris, L L, Singla, A, Overlee, B L, Heesom, K J, Sessions, R, Banks, L, Collins, B M, Berger, I, Billadeau, D D, Burstein, E & Cullen, P J 2017, ' Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling ', Nature Cell Biology, vol. 19, no. 10, pp. 1214–1225 . https://doi.org/10.1038/ncb3610

Following endocytosis into the endosomal network, integral membrane proteins undergo sorting for lysosomal degradation or are retrieved and recycled back to the cell surface. Here we describe the discovery of an ancient and conserved multiprotein com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5c857598e82e04766549d6478540a96
https://doi.org/10.1038/ncb3610

Retromer Controls Planar Polarity Protein Levels and Asymmetric Localization at Intercellular Junctions

Autor: Helen, Strutt, Paul F, Langton, Neil, Pearson, Kirsty J, McMillan, David, Strutt, Peter J, Cullen

Publikováno v: Current Biology

Summary The coordinated polarization of cells in the plane of a tissue, termed planar polarity, is a characteristic feature of epithelial tissues [1]. In the fly wing, trichome positioning is dependent on the core planar polarity proteins adopting as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9b9e09343bfeb429ddd07103aac9fb28
https://pubmed.ncbi.nlm.nih.gov/30661800