Activation of PPARs α, β/δ, and γ Impairs TGF-β1-Induced Collagens' Production and Modulates the TIMP-1/MMPs Balance in Three-Dimensional Cultured Chondrocytes

Autor: Paul-Emile Poleni, Stephanie Etienne, Emilie Velot, Patrick Netter, Arnaud Bianchi

Publikováno v: PPAR Research, Vol 2010 (2010)

Background and Purpose. We investigated the potency of Peroxisome Proliferators-Activated Receptors (PPARs) α, β/δ, and γ agonists to modulate Transforming Growth Factor-β1 (TGF-β1-) induced collagen production or changes in Tissue Inhibitor of

Externí odkaz: https://doaj.org/article/0f7e2a6f3f5446ac99181b939ad53110

Coinjection of CCK and leptin reduces food intake via increased CART/TRH and reduced AMPK phosphorylation in the hypothalamus

Autor: Sayaka Akieda-Asai, Yukari Date, Paul-Emile Poleni

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 306:E1284-E1291

CCK and leptin are anorectic hormones produced in the small intestine and white adipose tissue, respectively. Investigating how these hormones act together as an integrated anorectic signal is important for elucidating the mechanisms by which energy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d35349636c8323ddb35cb9cfdf8ff6
https://doi.org/10.1152/ajpendo.00664.2013

Involvement of guanylin and GC-C in rat mesenteric macrophages in resistance to a high-fat diet

Autor: Paul Emile Poleni, Eri Mutoh, Takashi Miyazawa, Atsushi Okamoto, Kazuyo Senba, Kenichi Yamahara, Yukari Date, Ichiro Okano, Mayumi Furuya, Shuichi Koda, Kenji Kangawa, Mikiya Miyazato, Akira Sawaguchi, Yoshiyuki Hizukuri, Masako Sugiyama, Fumiyo Aoyama, Sayaka Akieda-Asai

Publikováno v: Journal of Lipid Research, Vol 54, Iss 1, Pp 85-96 (2013)

A high-fat diet (HFD) is a well-known contributing factor in the development of obesity. Most rats fed HFDs become obese. Those that avoid obesity when fed HFDs are considered diet resistant (DR). We performed a microarray screen to identify genes sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac29d1ec9ae5b54a88a58f2917dbea9
https://doi.org/10.1194/jlr.m029017

Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co-culture biochip

Autor: Laurent Grsicom, Christiane Guillouzo, Anne Corlu, Geoffrey Madalinski, Florence Razan, Céline Brochot, Eric Leclerc, Leila Choucha-Snouber, Cécile Legallais, Caroline Aninat, Paul Emile Poleni

Publikováno v: Biotechnology and Bioengineering
Biotechnology and Bioengineering, Wiley, 2013, 110 (2), pp.597-608. ⟨10.1002/bit.24707⟩
Biotechnology and Bioengineering, 2013, 110 (2), pp.597-608. ⟨10.1002/bit.24707⟩

International audience; In this article, we present a liver-kidney co-culture model in a micro fluidic biochip. The liver was modeled using HepG2/C3a and HepaRG cell lines and the kidney using MDCK cell lines. To demonstrate the synergic interaction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b9090381337b95369d73bd1a9bf022
https://doi.org/10.1002/bit.24707

Sex differences in energy metabolism in pre-pubescent, early pubescent and adult rats

Autor: A. Miyashita, Paul-Emile Poleni, Sayaka Akieda-Asai, Yukari Date, Kazuyo Senba, E. Mutoh

Publikováno v: Obesity Research & Clinical Practice. 5:e119-e128

Summary Objective This study was intended to investigate sex differences in response to a high fat (HF) diet at three stages, pre-puberty, early puberty, and adulthood. Methods Body weight, energy intake, glucose, insulin, and leptin concentrations w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0141fb8408594f9e4ff4b9ca18de5be7
https://doi.org/10.1016/j.orcp.2010.12.006