Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Paul Eggleston"'
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88625 (2014)
Mosquito-borne diseases present some of the greatest health challenges faced by the world today. In many cases, existing control measures are compromised by insecticide resistance, pathogen tolerance to drugs and the lack of effective vaccines. In li
Externí odkaz:
https://doaj.org/article/7148eaa776c849daaf9655c79654969d
Autor:
Victoria Carter, Ann Underhill, Ibrahima Baber, Lakamy Sylla, Mounirou Baby, Isabelle Larget-Thiery, Agnès Zettor, Catherine Bourgouin, Ulo Langel, Ingrid Faye, Laszlo Otvos, John D Wade, Mamadou B Coulibaly, Sekou F Traore, Frederic Tripet, Paul Eggleston, Hilary Hurd
Publikováno v:
PLoS Pathogens, Vol 9, Iss 11, p e1003790 (2013)
A new generation of strategies is evolving that aim to block malaria transmission by employing genetically modified vectors or mosquito pathogens or symbionts that express anti-parasite molecules. Whilst transgenic technologies have advanced rapidly,
Externí odkaz:
https://doaj.org/article/b07c3bd8599e4ffd833def866a016621
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59264 (2013)
Diseases transmitted by mosquitoes have a devastating impact on global health and the situation is complicated due to difficulties with both existing control measures and the impact of climate change. Genetically modified mosquitoes that are refracto
Externí odkaz:
https://doaj.org/article/db3476cd867a43c1a8f7859497371793
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67364 (2013)
The deployment of transgenic mosquitoes carrying genes for refractoriness to malaria has long been seen as a futuristic scenario riddled with technical difficulties. The integration of anti-malarial effector genes and a gene-drive system into the mos
Externí odkaz:
https://doaj.org/article/615bce2c562e4c25b9c9b97fa11e95e4
Autor:
Janet M Meredith, Sanjay Basu, Derric D Nimmo, Isabelle Larget-Thiery, Emma L Warr, Ann Underhill, Clare C McArthur, Victoria Carter, Hilary Hurd, Catherine Bourgouin, Paul Eggleston
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e14587 (2011)
Diseases transmitted by mosquitoes have a devastating impact on global health and this is worsening due to difficulties with existing control measures and climate change. Genetically modified mosquitoes that are refractory to disease transmission are
Externí odkaz:
https://doaj.org/article/6b53c65bfff148db95aaf66accb9fa10
Publikováno v:
Insect Molecular Biology. 17:103-112
cDNAs of Anopheles gambiae Defensin 2 (AgDef2), Defensin 3 (AgDef3) and Defensin 4 (AgDef4), identified in the genome sequence, have been characterized and their expression profiles investigated. In contrast to both typical defensins and insect antim
Publikováno v:
Insect Molecular Biology. 15:497-505
Metacestodes of Hymenolepis diminuta secrete a molecule that decreases vitellogenin (Vg) synthesis in the beetle host, Tenebrio molitor. The 5608 bp T. molitor Vg cDNA represents a single-copy gene encoding a single open reading frame of 1821 amino a
Publikováno v:
Insect Molecular Biology. 15:393-401
A comparative analysis identified key cis-acting regulatory elements responsible for the temporal control of mosquito Defensin gene expression. The promoters of Anopheles gambiae Defensin 1 and two isoforms of Aedes aegypti Defensin A are up-regulate
Publikováno v:
Insect Molecular Biology. 15:129-136
Current techniques for the genetic engineering of insect genomes utilize transposable genetic elements, which are inefficient, have limited carrying capacity and give rise to position effects and insertional mutagenesis. As an alternative, we investi
Publikováno v:
Journal of Insect Physiology. 50:1037-1043
Many insects experience a decrease in reproductive output when parasitised. We are investigating mechanisms underlying this fecundity reduction using the rat tapeworm, Hymenolepis diminuta infection of Tenebrio molitor beetles. These include an incre