Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Paul E. Schurr"'
Publikováno v:
Atherosclerosis. 38:411-416
Ethyl 5( p -chlorophenoxy)-3-hydroxy-3-methylpentanoate (HMP), a new hypocholesterolemic compound, was evaluated in male rats at dosage levels ranging from 25–800 mg/kg/day and in SEA Japanese quail at approximately 200 mg/kg/day. In the rat, the a
Publikováno v:
Atherosclerosis. 56:313-321
Timefurone was evaluated in several animal models for cholesterol-lowering and anti-atherosclerotic activity. In normal male rats, a dose-response study with timefurone (3, 10, 30, 50 and 100 mg/kg/day) was conducted for 7 days. Significant activity
Publikováno v:
Journal of medicinal chemistry. 18(11)
A new assay for agents which normalize beta-lipoproteins in cholesterol-cholic acid fed rats is described. Both lowering of serum cholesterol and of serum heparin precipitable lipoproteins (HPL) were measured at the end of the treatment period. Compo
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781475793093
A new kind of pharmacologic activity called hypobetalipoproteinemia is described. Operationally the activity consists of a marked reduction of heparin precipitating lipoproteins (beta and/or pre-beta electrophoretic mobility) in hypercholesterolemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0fbeb8bc3f50c75c96011e16bb23c9c
https://doi.org/10.1007/978-1-4614-4618-7_14
https://doi.org/10.1007/978-1-4614-4618-7_14
Publikováno v:
Journal of medicinal chemistry. 22(1)
While the previously used displacement reaction of sodim 1-adamantyl oxide on 4-fluoronitrobenzene was applicable to the preparation of 4-(1-adamantyloxy)aniline and several related compounds, certain derivatives were not easily accessible by this ro
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781475793093
We describe high volume screening tests for hypobetalipoproteinemic agents in which compounds are administered orally to cholesterol-cholic acid fed (hypercholesterolemic) or normally fed weanling rats for 4 days. In these tests total serum cholester
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20a98eb6e6defd5efda2e7fe66c825cd
https://doi.org/10.1007/978-1-4614-4618-7_13
https://doi.org/10.1007/978-1-4614-4618-7_13
Autor:
Paul E. Schurr, Charles E. Day
Publikováno v:
Lipids. 12(1)
The hypobetalipoproteinemic activity of U-41,792 (1-[p-(1-adamantyloxy)-phenyl]-piperidine) is a marked and selective reduction of heparin precipitating lipoproteins (low density plus very low density lipoproteins) in cholesterol-cholic acid induced
Publikováno v:
Lipids. 7(1)
We describe a screening test for hypolipidemic agents in which compounds are administered orally to fasted rats after a single intravenous injection of 225 mg Triton WR-1339/kg and serum cholesterol and triglycerides are measured 43 hr post-Triton. C