Výsledky vyhledávání - "Paul E. Phillips"

Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications: a single-arm, open-label, phase 1/2 trial

Autor: Paul E. Phillips, Andras Perl, Ricardo Garcia, Zhi-Wei Lai, Ryan Kelly, Ashwini Shadakshari, Lisa Francis, Julie Yu, Ivan Marchena, Hajra Tily, Stephen V. Faraone, Maha Dawood, Thomas Winans

Publikováno v: The Lancet. 391:1186-1196

Summary Background Patients with systemic lupus erythematosus have T-cell dysfunction that has been attributed to the activation of the mammalian target of rapamycin (mTOR). Rapamycin inhibits antigen-induced T-cell proliferation and has been develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36dd7eaa4eec9cb373fa833436e7ee05
https://doi.org/10.1016/s0140-6736(18)30485-9

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BD-02 Blockade of the mechanistic target of rapamycin elicits rapid and lasting improvement of disease activity through restraining pro-inflammatory T cell lineage specification in patients with active SLE

Autor: Paul E. Phillips, Ryan Kelly, Zhi-Wei Lai, Lisa Francis, Andras Perl, Maha Dawood, Julie Yu, Ricardo Garcia, Thomas Winans, Stephen V. Faraone, Ashwini Shadakshari, Hajra Tily, Ivan Marchena

Publikováno v: Big Data Analyses.

Background Systemic lupus erythematosus (SLE) patients exhibit T-cell dysfunction that has been attributed to mechanistic target of rapamycin activation. Therefore, safety, tolerance, and efficacy of rapamycin were examined in a prospective biomarker

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f4eacfbd35b9bb7f18740bf79b16c3e
https://doi.org/10.1136/lupus-2018-lsm.26

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Comprehensive metabolome analyses reveal N-acetylcysteine-responsive accumulation of kynurenine in systemic lupus erythematosus: implications for activation of the mechanistic target of rapamycin

Autor: Andras Perl, Paul E. Phillips, Zhi-Wei Lai, Ryan Kelly, John M. Asara, Zachary Oaks, Robert Hanczko, Rebecca Borsuk

Publikováno v: Metabolomics. 11:1157-1174

Systemic lupus erythematosus (SLE) patients exhibit depletion of the intracellular antioxidant glutathione and downstream activation of the metabolic sensor, mechanistic target of rapamycin (mTOR). Since reversal of glutathione depletion by the amino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0836add2b5d122e1588b4f6e160e5427
https://doi.org/10.1007/s11306-015-0772-0

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N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: A randomized, double-blind, placebo-controlled trial

Autor: Adam Bartos, Eduardo Bonilla, Brandon Clair, Jianghong Yu, Andras Perl, Paul E. Phillips, Hajra Tily, Edward Doherty, Tiffany Caza, Ricardo Garcia, Stephen V. Faraone, Irene Ramos, Ioana L. Coman, Zhi-Wei Lai, John R. Jimah, Robert Hanczko, Lisa Francis, Maha Dawood, Gabriella Miklossy

Publikováno v: Arthritis & Rheumatism. 64:2937-2946

Objective Systemic lupus erythematosus (SLE) patients exhibit T cell dysfunction, which can be regulated through mitochondrial transmembrane potential (Δψm) and mammalian target of rapamycin (mTOR) by glutathione (GSH). This randomized, double-blin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da4181591ea34ff9f4f9d9ecb3408916
https://doi.org/10.1002/art.34502

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Endogenous retroviral pathogenesis in lupus

Autor: Andras Perl, David Fernandez, Paul E. Phillips, Tiffany Telarico

Publikováno v: Current Opinion in Rheumatology. 22:483-492

Purpose of review Genetic and environmental factors influence the development of systemic lupus erythematosus (SLE). Endogenous retroviruses (ERVs) are proposed as a molecular link between the human genome and environmental factors, such as viruses,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209a0ed749349a4e16c16efc3aecd974
https://doi.org/10.1097/bor.0b013e32833c6297

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Activation of Mammalian Target of Rapamycin Controls the Loss of TCRζ in Lupus T Cells through HRES-1/Rab4-Regulated Lysosomal Degradation

Autor: Werner Müller-Esterl, Andras Perl, Eduardo Bonilla, Stefanie Oess, David Fernandez, Paul E. Phillips, Frank A. Middleton, Mary K. Crow, Sanjay K. Banerjee, Tiffany Telarico, Qing Li

Publikováno v: The Journal of Immunology. 182:2063-2073

Persistent mitochondrial hyperpolarization (MHP) and enhanced calcium fluxing underlie aberrant T cell activation and death pathway selection in systemic lupus erythematosus. Treatment with rapamycin, which effectively controls disease activity, norm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::401b905e30df37ecd957e1a3aad1e8ea
https://doi.org/10.4049/jimmunol.0803600

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Molecular mimicry and immunomodulation by the HRES-1 endogenous retrovirus in SLE

Autor: David Fernandez, György Nagy, Tiffany Telarico, Agnes Koncz, Paul E. Phillips, Péter Gergely, Eduardo Bonilla, Edward Doherty, Andras Perl

Publikováno v: Autoimmunity. 41:287-297

Genetic and environmental factors are believed to influence development of systemic lupus erythematosus (SLE). Endogenous retroviruses (ERV) correspond to the integrated proviral form of infectious retroviruses, which are trapped within the genome du

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc4eb36355947b63ce322df1d04d1d7b
https://doi.org/10.1080/08916930802024764

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