Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Paul E. Miller"'
Autor:
Madison R. Mack, Yannick Miron, Fanny Chen, Paul E. Miller, Annie Zhang, Andrew Korotzer, Daniel Richman, Paul J. Bryce
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
IntroductionChronic itch is a central symptom of atopic dermatitis. Cutaneous afferent neurons express receptors interleukins (IL)-4, IL-13, and IL-33, which are type 2 cytokines that are elevated in atopic dermatitis. These neuronal cytokine recepto
Externí odkaz:
https://doaj.org/article/437ae312b43144a29ba413ca065680ec
Autor:
Anh Tuan Ton, William Nguyen, Katrina Sweat, Yannick Miron, Eduardo Hernandez, Tiara Wong, Valentyna Geft, Andrew Macias, Ana Espinoza, Ky Truong, Lana Rasoul, Alexa Stafford, Tamara Cotta, Christina Mai, Tim Indersmitten, Guy Page, Paul E. Miller, Andre Ghetti, Najah Abi-Gerges
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Late sodium current (late INa) inhibition has been proposed to suppress the incidence of arrhythmias generated by pathological states or induced by drugs. However, the role of late INa in the human heart is still poorly understood. We theref
Externí odkaz:
https://doaj.org/article/9370b3fc5ae4452d944997c5ebf6e262
Publikováno v:
Frontiers in Physiology, Vol 8 (2018)
To assess drug-induced pro-arrhythmic risk, especially Torsades de Pointe (TdP), new models have been proposed, such as in-silico modeling of ventricular action potential (AP) and stem cell-derived cardiomyocytes (SC-CMs). Previously we evaluated the
Externí odkaz:
https://doaj.org/article/ec8a7ab55f82419091b2e536c293fa1a
Autor:
Nathalie Nguyen, William Nguyen, Brynna Nguyenton, Phachareeya Ratchada, Guy Page, Paul E. Miller, Andre Ghetti, Najah Abi-Gerges
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Cardiac safety remains the leading cause of drug development discontinuation. We developed a human cardiomyocyte-based model that has the potential to provide a predictive preclinical approach for simultaneously predicting drug-induced inotropic and
Externí odkaz:
https://doaj.org/article/97038ffc628241a5a180e8e55611c140
Autor:
Oliver J. Britton, Najah Abi-Gerges, Guy Page, Andre Ghetti, Paul E. Miller, Blanca Rodriguez
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Background:In silico modeling could soon become a mainstream method of pro-arrhythmic risk assessment in drug development. However, a lack of human-specific data and appropriate modeling techniques has previously prevented quantitative comparison of
Externí odkaz:
https://doaj.org/article/f9f567a66ef045c5a3dc158a52de5b6a
Publikováno v:
Vet Ophthalmol
PRIMARY OBJECTIVE: To evaluate the effect of latex tip cover manufacturer on accuracy and repeatability of Tono-Pen Vet(™) in canine eyes. ANIMAL STUDIED: 12 enucleated globes from 6 dogs PROCEDURES: The anterior chamber was cannulated and connecte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d1b0e1c8f843ff6b15f18a6d8daf30
https://doi.org/10.1111/vop.12877
https://doi.org/10.1111/vop.12877
Publikováno v:
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 38(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77f160bd6f0075d825402810e8a8efb1
https://pubmed.ncbi.nlm.nih.gov/35537481
https://pubmed.ncbi.nlm.nih.gov/35537481
Autor:
Norbert Nagy, Kaisa Syrjänen, Piet Finckenberg, Gerd Wohlfahrt, Jouko Levijoki, Tuula Koskelainen, A. Koivisto, András Varró, Paul E. Miller, László Virág, Najah Abi-Gerges, Leena Otsomaa, Eero Mervaala, Andrea Ghetti, Hugh Chapman, Saara‐Elisa Peltokorpi, Aira Heikkilä, Norbert Jost, Guy Page, Julius Gy. Papp, Zsófia Kohajda
Publikováno v:
British Journal of Pharmacology
BACKGROUND AND PURPOSE: The lack of selective sodium-calcium exchanger (NCX) inhibitors has hampered the exploration of physiological and pathophysiological roles of cardiac NCX 1.1. We aimed to discover more potent and selective drug like NCX 1.1 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a59d209bbdf5c8135589cb2458da87f
https://doi.org/10.1111/bph.15257
https://doi.org/10.1111/bph.15257
Autor:
Nathalie Nguyen, Guy Page, Ky Truong, Najah Abi-Gerges, Paul E. Miller, Andrea Ghetti, William Nguyen, Phachareeya Ratchada, Tim Indersmitten
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Effects of non-cardiac drugs on cardiac contractility can lead to serious adverse events. Furthermore, programs aimed at treating heart failure have had limited success and this therapeutic area remains a major unmet medical need. The challenges in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d531e17fd3d8e41b58b7b242b6f3e9d
http://link.springer.com/article/10.1038/s41598-020-64657-2
http://link.springer.com/article/10.1038/s41598-020-64657-2
Autor:
Paul E. Miller, Erin M. Scott
Publikováno v:
Clinical Small Animal Internal Medicine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d997424d520910b649186c4746b2cdc0
https://doi.org/10.1002/9781119501237.ch138
https://doi.org/10.1002/9781119501237.ch138