Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Paul E. Lund"'
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
In response to intracellular signals, bacterial translational riboswitches embedded in mRNAs can regulate gene expression through inhibition of translation initiation. Here, the authors describe SiM-KARTS, a novel approach for detecting changes in th
Externí odkaz:
https://doaj.org/article/26903b0deccf4f77ae26a9a3ca7ddc73
Autor:
Michael M. Gottesman, Suresh V. Ambudkar, Chava Kimchi-Sarfaty, Jessica N. Pixley, Paul E. Lund, Shinobu Ohnuma, James Pan, King Leung Fung
PDF file - 2334K, SF1. Human P-gp is glycosylated in the LLC-PK1 cell line. SF2. Complete inhibition of drug efflux by P-gp wild-type and drug efflux of P-gp variants with high concentrations of a P-gp inhibitor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9925f545f9e254baf9ca1e8b9741c889
https://doi.org/10.1158/0008-5472.22400631.v1
https://doi.org/10.1158/0008-5472.22400631.v1
Autor:
Michael M. Gottesman, Suresh V. Ambudkar, Chava Kimchi-Sarfaty, Jessica N. Pixley, Paul E. Lund, Shinobu Ohnuma, James Pan, King Leung Fung
The drug efflux function of P-glycoprotein (P-gp) encoded by MDR1 can be influenced by genetic polymorphisms, including two synonymous changes in the coding region of MDR1. Here we report that the conformation of P-gp and its drug efflux activity can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2113d825ad9487d29dbfac787dd6bb85
https://doi.org/10.1158/0008-5472.c.6505635
https://doi.org/10.1158/0008-5472.c.6505635
Autor:
Michael M. Gottesman, Suresh V. Ambudkar, Chava Kimchi-Sarfaty, Jessica N. Pixley, Paul E. Lund, Shinobu Ohnuma, James Pan, King Leung Fung
PDF file - 92K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee7fce28ab29ee4f1de8b39595c8c76
https://doi.org/10.1158/0008-5472.22400628
https://doi.org/10.1158/0008-5472.22400628
Autor:
Benjamin Macadangdang, Ning Zhang, Paul E Lund, Andrew H Marple, Mitsunori Okabe, Michael M Gottesman, Daniel H Appella, Chava Kimchi-Sarfaty
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17981 (2011)
Peptide nucleic acid (PNA) is known to bind with extraordinarily high affinity and sequence-specificity to complementary nucleic acid sequences and can be used to suppress gene expression. However, effective delivery into cells is a major obstacle to
Externí odkaz:
https://doaj.org/article/dd7c724cc74243beaf6fc1084a3a3355
Publikováno v:
Nucleic Acids Research
Ribosomal protein S1 plays important roles in the translation initiation step of many Escherichia coli mRNAs, particularly those with weak Shine-Dalgarno sequences or structured 5′ UTRs, in addition to a variety of cellular processes beyond the rib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08462b5b084e30f756b4b01bad529641
https://pubmed.ncbi.nlm.nih.gov/31832686
https://pubmed.ncbi.nlm.nih.gov/31832686
Autor:
Stephen L Hayward, Nils G. Walter, Paul E. Lund, Muneesh Tewari, Alexander Johnson-Buck, Qing Kang
Publikováno v:
Journal of the American Chemical Society. 140(37)
Conventional techniques for detecting rare DNA sequences require many cycles of PCR amplification for high sensitivity and specificity, potentially introducing significant biases and errors. While amplification-free methods exist, they rarely achieve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::243b9170ee29107aedbe91b460e72234
https://pubmed.ncbi.nlm.nih.gov/30125495
https://pubmed.ncbi.nlm.nih.gov/30125495
Autor:
Rebecca M. Bartke, Jiarui Wang, David Smith, Sethuramasundaram Pitchiaya, Paul E. Lund, J. Damon Hoff, Ajitha S. Cristie-David, May Daher, Nguyen N. Vo, Nils G. Walter, Joshua Karslake, Krishna C. Suddala, Xiang Li, Soumi Ghosh, Julia R. Widom, Qian Hou, Soma Dhakal, Laurie A. Heinicke, Victoria Rai, Jun Park, Maxwell S. Denies, Thomas C. Custer, Matthew L. Kahlscheuer, Adam G. Krieger, Elizabeth L. Cameron, Jieming Li
Publikováno v:
Biopolymers. 103:296-302
Four days after the announcement of the 2014 Nobel Prize in Chemistry for “the development of super-resolved fluorescence microscopy” based on single molecule detection, the Single Molecule Analysis in Real-Time (SMART) Center at the University o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::357b2cf09a0ad6bbfc1a188ad627ec84
https://doi.org/10.1002/bip.22603
https://doi.org/10.1002/bip.22603
Publikováno v:
Pharmaceutical Research. 27:400-420
Over the last two decades, small interfering RNA (siRNA)-mediated gene silencing has quickly become one of the most powerful techniques used to study gene function in vitro and a promising area for new therapeutics. Delivery remains a significant imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7cdba834f62db1db117c3d8c68d1250
https://doi.org/10.1007/s11095-009-0012-2
https://doi.org/10.1007/s11095-009-0012-2
Autor:
Eric Borguet, David H. Waldeck, Yufan He, Amit Paul, Richard M. Watson, Kathleen Burke, Catalina Achim, Yangjun Xing, Paul E. Lund
Publikováno v:
The Journal of Physical Chemistry C. 112:7233-7240
Self-assembled monolayers (SAMs) of single-stranded peptide nucleic acids (PNAs) containing 3 to 7 thymine (T) nucleotides, a C-terminus cysteine, and an N-terminus ferrocene group were formed on gold electrodes. The existence of two redox environmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be02f9a5f4608dab6dca0fbc848e14b3
https://doi.org/10.1021/jp711764q
https://doi.org/10.1021/jp711764q