Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Paul E. Kroeger"'
Autor:
Yan Luo, Shayna K. Rockow-Magnone, Paul E. Kroeger, Leigh Frost, Zehan Chen, Edward K.-H. Han, Shi-Chung Ng, Robert L. Simmer, Vincent L. Giranda
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 3, Iss 5, Pp 411-419 (2001)
Checkpoint kinase 1 (Chki) is a checkpoint gene that is activated after DNA damage. It phosphorylates and inactivates the Cdc2 activating phosphatase Cdc25C. This in turn inactivates Cdc2, which leads to G2/M arrest. We report that blocking Chki expr
Externí odkaz:
https://doaj.org/article/7121327b51a74cf29e5c0cdb49dae0dc
Autor:
Jun Chen, Wei Wu, Stephen K. Tahir, Paul E. Kroeger, Saul H. Rosenberg, Lex M. Cowsert, Frank Bennett, Stanislaw Krajewski, Maryla Krajewska, Kate Welsh, John C. Reed, Shi-Chung Ng
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 2, Iss 3, Pp 235-241 (2000)
Survivin, a member of the inhibitor of apoptosis protein (IAP) family, is detected in most common human cancers but not in adjacent normal cells. Previous studies suggest that survivin associates with the mitotic spindle and directly inhibits caspase
Externí odkaz:
https://doaj.org/article/59fbb30bc5034417a9a1b3c18c1b0f2f
Autor:
Mark G. Anderson, Saul H. Rosenberg, Christin Tse, Paul E. Kroeger, Steve W. Elmore, Haichao Zhang, Paul Hessler, Viswanath Devanarayan, Mary K. Joseph, John Wass, Stephen K. Tahir
ABT-263 inhibits the antiapoptotic proteins Bcl-2, Bcl-xL, and Bcl-w and has single-agent efficacy in numerous small cell lung carcinoma (SCLC) and leukemia/lymphoma cell lines in vitro and in vivo. It is currently in clinical trials for treating pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274302e4a8205b46295646f2cb528c19
https://doi.org/10.1158/1535-7163.c.6532101.v1
https://doi.org/10.1158/1535-7163.c.6532101.v1
Autor:
Qingen Ke, S. Ananth Karumanchi, Ravi Thadhani, Bhargavi Yalamarti, Soochan Bae, Sangita Choudhury, Peter M. Kang, Hyeon Yu, Paul E. Kroeger
Publikováno v:
Cardiovascular Research. 91:632-639
Aims Vitamin D deficiency is associated with cardiac hypertrophy and heart failure, and vitamin D therapy prevents the progression of cardiac hypertrophy in animal models. Here, we examine whether vitamin D therapy prevents progression of pre-existin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::109025cdccb0d8c4b52c253ac638d777
https://doi.org/10.1093/cvr/cvr133
https://doi.org/10.1093/cvr/cvr133
Autor:
Vincent L. Giranda, Paul E. Kroeger, Yan Luo, Xuesong Liu, Qun Li, Keith W. Woods, Jieyi Wang, Chun-Ying Li, Julie L. Wilsbacher, Saul H. Rosenberg, Paul Hessler, Jean Y. J. Wang, Yan Shi
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 8, Pp 828-837 (2008)
Both Akt and Aurora A kinase have been shown to be important targets for intervention for cancer therapy. We report here that Compound A (A-443654), a specific Akt inhibitor, interferes with mitotic progression and bipolar spindle formation. Compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::982ea3887aa82354c2c25996a4f4da77
Autor:
Venkatesha Shivalingappa, Peter M. Kang, S. Ananth Karumanchi, Steven G. Achinger, Debra L. Rigor, Juan Carlos Ayus, Ravi Thadhani, Natalya Bodyak, Paul E. Kroeger, Qingen Ke, Yee-Shiuan Chen, Ruth R. Wu-Wong, Hector Tamez, Isaac E. Stillman
Publikováno v:
Proceedings of the National Academy of Sciences. 104:16810-16815
Observations in hemodialysis patients suggest a survival advantage associated with activated vitamin D therapy. Left ventricular (LV) structural and functional abnormalities are strongly linked with hemodialysis mortality. Here, we investigated wheth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d669acea2b02d9333a41f2eb02ec47f
https://doi.org/10.1073/pnas.0611202104
https://doi.org/10.1073/pnas.0611202104
Autor:
Leigh Frost, Cristina M. Rondinone, Deanna L. Haasch, Cathleen E Berg, Terry Pederson, Paul E. Kroeger, Jill E. Clampit
Publikováno v:
Biochemical and Biophysical Research Communications. 343:361-368
Activation of PKCtheta is associated with lipid-induced insulin resistance and PKCtheta knockout mice are protected from the lipid-induced defects. However, the exact mechanism by which PKCtheta contributes to insulin resistance is not known. To inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf5736199c06b8b295db4bada8f70a5
https://doi.org/10.1016/j.bbrc.2006.02.177
https://doi.org/10.1016/j.bbrc.2006.02.177
Publikováno v:
Atherosclerosis. 186:20-28
Vitamin D analogs provide survival benefit for chronic kidney disease patients with cardiovascular complications. Activation of smooth muscle cells plays a role in cardiovascular diseases. It is not known how Vitamin D analogs modulate gene expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::068b7e089429d8580e84dd3f28010d5d
https://doi.org/10.1016/j.atherosclerosis.2005.06.046
https://doi.org/10.1016/j.atherosclerosis.2005.06.046
Autor:
T. F. Holzman, Uri S. Ladror, Kenneth Jarvis, Hing L. Sham, Mark G. Anderson, Shi-Chung Ng, Le Wang, David Frost, Luis E. Rodriguez, Saul H. Rosenberg, Steven W. Muchmore, John E. Harlan, Jerry Cohen, Debra Ferguson, Yi-Chun Wang, Paul E. Kroeger, Vincent S. Stoll, Gerard M. Sullivan, Ingrid B J K Joseph, Nan-Horng Lin, Wen-Zhen Gu, Haiying Zhang, Clarissa G. Jakob, Kennan C. Marsh, Karl A. Walten
Publikováno v:
Anti-Cancer Drugs. 16:1059-1069
Ras mutation has been detected in approximately 20-30% of all human carcinomas, primarily in pancreatic, colorectal, lung and bladder carcinomas. The indirect inhibition of Ras activity by inhibiting farnesyltransferase (FTase) function is one therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857e4ed91e308ba6720a6ef05b9ad4f4
https://doi.org/10.1097/00001813-200511000-00004
https://doi.org/10.1097/00001813-200511000-00004
Publikováno v:
Cancer Chemotherapy and Pharmacology. 57:234-240
1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and its analogues have been shown to inhibit proliferation of human cancer cells mediated by vitamin D receptor (VDR). The over-expression of 25-hydroxyvitamin D-24-hydroxylase (CYP24A1), an enzyme involved in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37df097207a14a1ea840c6914ca8b593
https://doi.org/10.1007/s00280-005-0059-7
https://doi.org/10.1007/s00280-005-0059-7