Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Paul E. Juniewicz"'
Autor:
Eric Raymond, Alex V. Trevino, Alexandra Vaisman, Stephen G. Chaney, Sandrine Faivre, Paul E. Juniewicz, Maryanne C. Herzig, William G. Chapman, Jan M. Woynarowski, Brenda Arnett, Maria Varchenko
Publikováno v:
Molecular Pharmacology. 58:920-927
Damage to cellular DNA is believed to determine the antiproliferative properties of platinum (Pt) drugs. This study characterized DNA damage by oxaliplatin, a diaminocyclohexane Pt drug with clinical antitumor activity. Compared with cisplatin, oxali
Autor:
James Rake, Daniel L. Dexter, Daniel D. Von Hoff, Susan G. Hilsenbeck, Steven D. Weitman, Paul E. Juniewicz, Jennifer Marty, G. Mangold
Publikováno v:
Cancer Chemotherapy and Pharmacology. 43:402-408
Purpose: Tirapazamine (3-amino-1,2,4-benzotriazine 1,4-dioxide; SR 4233) is a bioreductive agent that exhibits relatively selective cytotoxicity towards cells under hypoxic conditions and can enhance the antitumor activity of many standard oncolytics
Publikováno v:
Steroids. 57:530-536
Using unlabeled androsterone as starting material, 5α-[16,16-2H2]androstan-3α-ol-17-one was synthesized by exchange using deuterated potassium methoxide. This labeled androsterone product was reduced by sodium borodeuteride, which gave predominantl
Publikováno v:
Molecular pharmacology. 54(5)
Oxaliplatin is a clinical anticancer drug with a pharmacological profile distinct from that of cisplatin. Our studies compared site- and region-specificity of lesions induced by oxaliplatin and cisplatin in naked and intracellular DNA, respectively.
Publikováno v:
The Journal of urology. 152(3)
A long-term study on the requirement of the testis in establishing the sensitivity of the canine prostate to develop benign prostatic hyperplasia (BPH) was conducted using 23 aging beagles both with and without their testes. The dogs had received lon
Autor:
John P. Mallamo, Rudolph K. Kullnig, Joseph R. Wetzel, Malcolm R. Bell, Richard C. Winneker, Garry M. Pilling, Paul E. Juniewicz, Henry R. Luss, Paul J. Kowalczyk, Frederick H. Batzold
Publikováno v:
Journal of medicinal chemistry. 35(10)
Complementarity of electrostatic potential surface maps was utilized in defining bioisosteric steroidal androgen receptor antagonists. Semiempirical and ab initio level calculations performed on a series of methanesulfonyl heterocycles indicated the
Autor:
Joseph E. Oesterling, Paul E. Juniewicz, John D. Strandberg, Larry L. Ewing, Ronald E. Steele, Justin R. Walters, Donald S. Coffey
Publikováno v:
Journal of Urology. 139:832-839
To evaluate the role of aromatase inhibitors in the treatment of benign prostatic hyperplasia (BPH), the effects of a potent, oral, nonsteroidal aromatase inhibitor [4-(5,6,7,8-tetrahydroimidazo[1,5a]pyridin-5yl)benzonitrile; CGS-16949A, CIBA-GEIGY]
Autor:
C. Dembeck, Roger C. Sanders, Donald S. Coffey, Ulrike M. Hamper, Paul E. Juniewicz, W. F. Dahnert, Larry L. Ewing
Publikováno v:
The Prostate. 14:55-64
The use of transrectal ultrasonography to estimate canine prostatic size in situ was evaluated and compared to that of direct measurement via calipers and an in situ radiologic procedure. The length, width, and depth of prostates were measured by tra
Autor:
Donald S. Coffey, Ronald E. Steele, Joseph E. Oesterling, Paul E. Juniewicz, Larry L. Ewing, Gordon D. Niswender, Justin R. Walters
Publikováno v:
Journal of Urology. 139:827-831
Chronic treatment of intact male beagles with an orally active nonsteroidal aromatase inhibitor (4-(5,6,7,8-tetrahydroimidazo [1,5a] pyridin-5-yl) benzonitrile hydrochloride; CGS 16949; CIBA-GEIGY) at a dosage of 2.5 mg./kg. per day for six months re