Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Paul E. Hughes"'
Autor:
Bing Z. Carter, Po Yee Mak, Wenjing Tao, Edward Ayoub, Lauren B. Ostermann, Xuelin Huang, Sanam Loghavi, Steffen Boettcher, Yuki Nishida, Vivian Ruvolo, Paul E. Hughes, Phuong K. Morrow, Torsten Haferlach, Steven Kornblau, Muharrem Muftuoglu, Michael Andreeff
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract TP53-mutant acute myeloid leukemia (AML) respond poorly to currently available treatments, including venetoclax-based drug combinations and pose a major therapeutic challenge. Analyses of RNA sequencing and reverse phase protein array datase
Externí odkaz:
https://doaj.org/article/ed4c5f0838c540e4bdf8c2b8285492df
Autor:
Bing Z. Carter, Po Yee Mak, Wenjing Tao, Edward Ayoub, Lauren B. Ostermann, Xuelin Huang, Sanam Loghavi, Steffen Boettcher, Yuki Nishida, Vivian Ruvolo, Paul E. Hughes, Phuong K. Morrow, Torsten Haferlach, Steven Kornblau, Muharrem Muftuoglu, Michael Andreeff
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/3a3640a997424898be13fe344335ea7a
Autor:
Emma C. Greenwood, Jonathon van Dissel, Jessica Rayner, Paul E. Hughes, William H. E. J. van Wettere
Publikováno v:
Animals, Vol 9, Iss 9, p 658 (2019)
Alternative lactation housing could reduce aggression when sows are mixed. We aimed to compare the effects of mixing sows in lactation (with or without piglets), at weaning or after insemination, and determine the effects of lactation housing on the
Externí odkaz:
https://doaj.org/article/03e93d93495e4bafb1908899f9f0ebcf
Autor:
Emma Catharine Greenwood, William H. E. J. van Wettere, Jessica Rayner, Paul E. Hughes, Kate L. Plush
Publikováno v:
Animals, Vol 9, Iss 1, p 8 (2018)
When sows are mixed into groups, hierarchies form and resulting aggression and stress can affect production and welfare. This study determined the effect of providing point-source materials on aggressive and play behaviors in gestating sows. Large wh
Externí odkaz:
https://doaj.org/article/a4eb10ee5146462d852e0af69cdc68ec
Autor:
Angela Coxon, Isabelle Dussault, Richard Kendall, Robert Radinsky, Jean-Christophe Harmange, Deborah M. Choquette, Daniel Baker, Michael A. Damore, Jonathan Werner, Jodi Moriguchi, Paula J. Kaplan-Lefko, Benny Amore, Teresa L. Burgess, Hue T. Kha, Martin A. Broome, Yihong Zhang, Yajing Yang, Sean Caenepeel, Karen Rex, Paul E. Hughes
Supplementary methods of tumor xenograft studies and light microscopic evaluation of tumor xenografts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::809519f7573d2d85599f5e08e9814dd8
https://doi.org/10.1158/1535-7163.22507701
https://doi.org/10.1158/1535-7163.22507701
Autor:
Angela Coxon, Isabelle Dussault, Richard Kendall, Robert Radinsky, Jean-Christophe Harmange, Deborah M. Choquette, Daniel Baker, Michael A. Damore, Jonathan Werner, Jodi Moriguchi, Paula J. Kaplan-Lefko, Benny Amore, Teresa L. Burgess, Hue T. Kha, Martin A. Broome, Yihong Zhang, Yajing Yang, Sean Caenepeel, Karen Rex, Paul E. Hughes
AMG 337 KINOME scan binding data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ce3cdee7da5472faad9adbf13ac723
https://doi.org/10.1158/1535-7163.22507716
https://doi.org/10.1158/1535-7163.22507716
Autor:
Aaron N. Hata, Paul E. Hughes, Cyril H. Benes, Angela Coxon, Sean P. Brown, Kristopher A. Sarosiek, Justin F. Gainor, Christopher G. Azzoli, Anna F. Farago, Zofia Piotrowska, Lecia V. Sequist, Colleen Keyes, John H. Shin, Daniel P. Cahill, Kevin A. Raskin, Cameron D. Wright, Michael Lanuti, Lorin A. Ferris, Kristof Vajda, Diamanda Rigas, Cameron Fraser, Chendi Li, Hannah L. Archibald, Maria Gomez-Caraballo, Nicole Phan, Samantha J. Bilton, Daria Timonina, Sean Caenepeel, Faria M. Siddiqui, Varuna Nangia
BH3 mimetic drugs, which inhibit prosurvival BCL2 family proteins, have limited single-agent activity in solid tumor models. The potential of BH3 mimetics for these cancers may depend on their ability to potentiate the apoptotic response to chemother
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70abe6bdd9a6b3e57487dfcfd1b546b5
https://doi.org/10.1158/2159-8290.c.6547298.v1
https://doi.org/10.1158/2159-8290.c.6547298.v1
Autor:
Michael Andreeff, Phuong K. Morrow, Xiaoyue Chen, Paul E. Hughes, Elias J. Jabbour, Marina Konopleva, Venkata L. Battula, Duncan H. Mak, Xiangmeng Wang, Vinitha M. Kuruvilla, Vivian Ruvolo, Qi Zhang, Wenjing Tao, Po Yee Mak, Bing Z. Carter
MCL-1 is known to play a major role in resistance to BCL-2 inhibition, but the contribution of other BCL-2 family proteins has not been fully explored. We, here, demonstrate the ineffectiveness of MCL-1 inhibitor AMG176 in venetoclax-resistant, and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::392313a08e17e9b157cafff9a72d8ade
https://doi.org/10.1158/1535-7163.c.6543211
https://doi.org/10.1158/1535-7163.c.6543211
Autor:
Angela Coxon, Isabelle Dussault, Richard Kendall, Robert Radinsky, Jean-Christophe Harmange, Deborah M. Choquette, Daniel Baker, Michael A. Damore, Jonathan Werner, Jodi Moriguchi, Paula J. Kaplan-Lefko, Benny Amore, Teresa L. Burgess, Hue T. Kha, Martin A. Broome, Yihong Zhang, Yajing Yang, Sean Caenepeel, Karen Rex, Paul E. Hughes
Tumor cell line profiling data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d19fcb3c43643eae23c6970fc140e93
https://doi.org/10.1158/1535-7163.22507713.v1
https://doi.org/10.1158/1535-7163.22507713.v1
Autor:
Angela Coxon, Isabelle Dussault, Richard Kendall, Robert Radinsky, Jean-Christophe Harmange, Deborah M. Choquette, Daniel Baker, Michael A. Damore, Jonathan Werner, Jodi Moriguchi, Paula J. Kaplan-Lefko, Benny Amore, Teresa L. Burgess, Hue T. Kha, Martin A. Broome, Yihong Zhang, Yajing Yang, Sean Caenepeel, Karen Rex, Paul E. Hughes
The MET receptor tyrosine kinase is involved in cell growth, survival, and invasion. Clinical studies with small molecule MET inhibitors have shown the role of biomarkers in identifying patients most likely to benefit from MET-targeted therapy. AMG 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0074a6c1183119f6d623235dd01743f
https://doi.org/10.1158/1535-7163.c.6538764
https://doi.org/10.1158/1535-7163.c.6538764