Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Paul E. Harrington"'
Autor:
Kaustav Biswas, J. Russell Lipford, Silvia Materna-Reichelt, Jennifer R. Allen, Christopher Mohr, Holger Beckmann, Peter Jaeckel, Richard Kendall, David Malwitz, Ken Dellamaggiore, Kristin L. Andrews, Andrew Tasker, Paul E. Harrington
Publikováno v:
ACS Medicinal Chemistry Letters. 6:68-72
The kinase/endonuclease inositol requiring enzyme 1 (IRE1α), one of the sensors of unfolded protein accumulation in the endoplasmic reticulum that triggers the unfolded protein response (UPR), has been investigated as an anticancer target. We identi
Autor:
Neeta P. Fogg, Carolyn E. Hawley, Lara A. Barbir, Paul E. Harrington, Brian T. McMahon, Elizabeth da Silva Cardoso
Publikováno v:
Rehabilitation Research, Policy, and Education. 28:183-199
Purpose:To examine the recent labor market indicators of science, technology, engineering, and mathematics (STEM) versus non-STEM college graduates with disabilities.Method:The sample included bachelor of science (B.S.)/B.S.-level college graduates i
Autor:
Pierre Deprez, Paul M. Wehn, Jeff D. Reagan, Minghan Wang, Paul E. Harrington, Mark P. Grillo, Kanaka Pattabiraman, James Davis, Charles Henley, Sean Morony, Taoues Temal, Christopher H. Fotsch, Steve F. Poon, Timothy J. Carlson, David J. St. Jean, Sarah E. Lively, Yuhua Yang, Jenny Ying-Lin Lu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:6625-6628
A series of urea based calcimimetics was optimized for potency and oral bioavailability. Crucial to this process was overcoming the poor pharmacokinetic properties of lead thiazole 1. Metabolism-guided modifications, characterized by the use of metab
Autor:
Andrew Tasker, Andrea Itano, Anu Gore, Paul E. Harrington, Mike Frohn, Victor J. Cee, Michele McElvain, Min Wong, Mike Fiorino, Alexander J. Pickrell, Kelvin K. C. Sham, Han Xu, Brian A. Lanman, Anthony B. Reed, Yang Xu, Susana C. Neira, Scot Middleton, Henry Morrison
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1779-1783
Replacement of the azetidine carboxylate of an S1P1 agonist development candidate, AMG 369, with a range of acyclic head-groups led to the identification of a novel, S1P3-sparing S1P1 agonist, (−)-2-amino-4-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiaz
Autor:
Kelvin K. C. Sham, Lewis D. Pennington, Paul E. Harrington, Matthew R. Lee, Michele McElvain, Xuxia Zhang, Heather A. Arnett, Min Wong, Alexander J. Pickrell, Anthony B. Reed, Henry Morrison, Victor J. Cee, Mike Fiorino, Christopher H. Fotsch, Michael J. Frohn, Yang Xu, Michael Croghan, Han Xu, Brian A. Lanman, Andrew Tasker, Michelle Horner
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:527-531
We reveal how a N-scan SAR strategy (systematic substitution of each CH group with a N atom) was employed for quinolinone-based S1P(1) agonist 5 to modulate physicochemical properties and optimize in vitro and in vivo activity. The diaza-analog 17 di
Autor:
Michael Croghan, Andrew Tasker, Matthew R. Lee, Xuxia Zhang, Heather A. Arnett, Victor J. Cee, Anthony B. Reed, Kelvin K. C. Sham, Michele McElvain, Henry Morrison, Alexander J. Pickrell, Lewis D. Pennington, Mike Frohn, Yang Xu, Paul E. Harrington, Min Wong, Han Xu, Brian A. Lanman, Mike Fiorino, Christopher H. Fotsch
Publikováno v:
ACS Medicinal Chemistry Letters. 3:74-78
The optimization of a series of S1P1 agonists with limited activity against S1P3 is reported. A polar headgroup was used to improve the physicochemical and pharmacokinetic parameters of lead quinolinone 6. When dosed orally at 1 and 3 mg/kg, the azah
Autor:
Min Wong, Heather A. Arnett, Michael Croghan, Michele McElvain, Yang Xu, Xuxia Zhang, Matthew R. Lee, Lewis D. Pennington, Paul E. Harrington, Henry Morrison, Victor J. Cee, Anthony B. Reed, Michael J. Frohn, Alexander J. Pickrell, Mike Fiorino, Kelvin K. C. Sham, Han Xu, Brian A. Lanman, Christopher H. Fotsch, Michelle Horner
Publikováno v:
ACS Medicinal Chemistry Letters. 2:752-757
The sphingosine-1-phosphate-1 receptor (S1P1) and its endogenous ligand sphingosine-1-phosphate (S1P) cooperatively regulate lymphocyte trafficking from the lymphatic system. Herein, we disclose 4-methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]
Autor:
Paul E. Harrington, Neeta P. Fogg
Publikováno v:
Public Policy & Aging Report. 21:11-17
Autor:
Yuhua Yang, Adam Davenport, Michael G. Kelly, Andrew Tasker, Michael Croghan, Guomin Yao, Fred D. Lott, Jeff D. Reagan, Christopher H. Fotsch, James Davis, Minghan Wang, Chiara Ghiron, Steve F. Poon, Qingping Zeng, David Martin, Elena Portero-Larragueta, Thomas Stephen Coulter, David J. St. Jean, Jonathan Hutchinson, Charles Henley, Kelly Regal, Paul E. Harrington, Sean Morony, Jeffrey Clarine, Jenny Ying-Lin Lu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:5544-5547
The discovery of a series of novel and orally efficacious type II calcimimetics, developed from the lead compound 1, is described herein. Compound 22 suppressed plasma PTH levels relative to vehicle when dosed orally in a rat pharmacodynamic model.
Publikováno v:
Journal of Vocational Rehabilitation. 33:193-202
Recent data from the U.S. Bureau of Labor Statistics allows assessment of the impact of the Great Recession on working age persons with disabilities in America. Following an overview of the nature and scope of the Great Recession, the labor market ex