Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Paul E. Hardin"'
Publikováno v:
Frontiers in Systems Neuroscience, Vol 17 (2023)
The role of the circadian system in memory formation is an important question in neurobiology. Despite this hypothesis being intuitively appealing, the existing data is confusing. Recent work in Drosophila has helped to clarify certain aspects of the
Externí odkaz:
https://doaj.org/article/fec470b0d8c345ff91f811c1758a20a8
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101893- (2021)
Summary: The vrille (vri) gene encodes a transcriptional repressor required for Drosophila development as well as circadian behavior in adults. Alternate first exons produce vri transcripts predicted to produce a short VRI isoform during development
Externí odkaz:
https://doaj.org/article/fdb20a5f887241afa137ffdfd2d51105
Publikováno v:
Neurobiology of Sleep and Circadian Rhythms, Vol 5, Iss , Pp 58-67 (2018)
In the early 1980s Jeff Hall and Michael Rosbash at Brandeis University and Mike Young at Rockefeller University set out to isolate the period (per) gene, which was recovered in a revolutionary genetic screen by Ron Konopka and Seymour Benzer for mut
Externí odkaz:
https://doaj.org/article/0923e8a1d1d64d7a9e068238c48b1c02
Autor:
Parul Agrawal, Paul E. Hardin
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 12, Pp 4227-4238 (2016)
Circadian clocks in eukaryotes keep time via cell-autonomous transcriptional feedback loops. A well-characterized example of such a transcriptional feedback loop is in Drosophila, where CLOCK-CYCLE (CLK-CYC) complexes activate transcription of period
Externí odkaz:
https://doaj.org/article/d565f64a31aa4c5e9a50c147daad027a
Publikováno v:
PLoS Genetics, Vol 12, Iss 11, p e1006430 (2016)
The Drosophila circadian oscillator controls daily rhythms in physiology, metabolism and behavior via transcriptional feedback loops. CLOCK-CYCLE (CLK-CYC) heterodimers initiate feedback loop function by binding E-box elements to activate per and tim
Externí odkaz:
https://doaj.org/article/5ca9bf9b2a754ca7b4fa7a8fb4a747c8
Publikováno v:
Curr Biol
Summary The Drosophila circadian clock is driven by a transcriptional feedback loop in which CLOCK-CYCLE (CLK-CYC) binds E-boxes to transcribe genes encoding the PERIOD-TIMELESS (PER-TIM) repressor, which releases CLK-CYC from E-boxes to inhibit tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8351cc4edfe41cca3dcbbe7c330274
https://europepmc.org/articles/PMC8511158/
https://europepmc.org/articles/PMC8511158/
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101893-(2021)
Summary The vrille (vri) gene encodes a transcriptional repressor required for Drosophila development as well as circadian behavior in adults. Alternate first exons produce vri transcripts predicted to produce a short VRI isoform during development a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed821a19ebf6430bbf73d51e247b2b33
http://www.sciencedirect.com/science/article/pii/S2589004220310907
http://www.sciencedirect.com/science/article/pii/S2589004220310907
Autor:
David L. Allen, Guruswamy Mahesh, Richard A. L. Jones, Courtney Caster, Evan B Ost, Ravi Amunugama, Gustavo B. S. Rivas, Paul E. Hardin
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Circadian clocks keep time via ~ 24 h transcriptional feedback loops. In Drosophila, CLOCK-CYCLE (CLK-CYC) activators and PERIOD-TIMELESS (PER-TIM) repressors are feedback loop components whose transcriptional status varies over a circadian cycle. Al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::537e7d6b3fa67bcfe8edde53a1e88f8c
http://europepmc.org/articles/PMC7578830
http://europepmc.org/articles/PMC7578830
Publikováno v:
iScience
Summary The vrille (vri) gene encodes a transcriptional repressor required for Drosophila development as well as circadian behavior in adults. Alternate first exons produce vri transcripts predicted to produce a short VRI isoform during development a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d666b9f7b0e7b80a7a3dc513f67aaa39
https://pubmed.ncbi.nlm.nih.gov/33364582
https://pubmed.ncbi.nlm.nih.gov/33364582
Publikováno v:
Neurobiology of Sleep and Circadian Rhythms
Neurobiology of Sleep and Circadian Rhythms, Vol 5, Iss, Pp 58-67 (2018)
Neurobiology of Sleep and Circadian Rhythms, Vol 5, Iss, Pp 58-67 (2018)
In the early 1980s Jeff Hall and Michael Rosbash at Brandeis University and Mike Young at Rockefeller University set out to isolate the period (per) gene, which was recovered in a revolutionary genetic screen by Ron Konopka and Seymour Benzer for mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61fbb51421b5c5adc5d4d90494e4e77d
https://doi.org/10.1016/j.nbscr.2018.02.004
https://doi.org/10.1016/j.nbscr.2018.02.004