Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Paul E. Gottschall"'
Autor:
Katherine Conant, Paul E Gottschall
This book presents the reader with an understanding of the role played by matrix metalloproteinases (MMPs) in the normal and diseased central nervous system (CNS). These enzymes may be important to brain development, and may also contribute to tissue
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47226 (2012)
The chondroitin sulfate-bearing proteoglycans, also known as lecticans, are a major component of the extracellular matrix (ECM) in the central nervous system and regulate neural plasticity. Growing evidence indicates that endogenous, extracellular me
Externí odkaz:
https://doaj.org/article/c041cdc26ae84110b483e1fa6e2bb960
Autor:
Matthew D Howell, Paul E Gottschall
Publikováno v:
ASN Neuro, Vol 4 (2012)
DS (Down syndrome), resulting from trisomy of chromosome 21, is the most common cause of genetic mental retardation; however, the molecular mechanisms underlying the cognitive deficits are poorly understood. Growing data indicate that changes in abun
Externí odkaz:
https://doaj.org/article/4d3faf4a9dbd490e985fda3b42edfb36
Autor:
Matthew D. Howell, Paul E. Gottschall
Publikováno v:
Matrix biology : journal of the International Society for Matrix Biology
The components of the adult extracellular matrix in the central nervous system form a lattice-like structure that is deposited as perineuronal nets, around axon initial segments and as synapse-associated matrix. An abundant component of this matrix i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30dec661135d2ca3543522cae8701c68
http://europepmc.org/articles/PMC5068130
http://europepmc.org/articles/PMC5068130
Autor:
Marcia N. Gordon, Paul E. Gottschall, Dave Morgan, Niki C Carty, Nicholas Muzyczka, Mary Mercer, Craig Meyers, Daniel C. Lee, Kevin Nash
Publikováno v:
Molecular Therapy. 16:1580-1586
Reduction of Aβ deposition is a major therapeutic strategy in Alzheimer's disease (AD). The concentration of Aβ in the brain is modulated not only by Aβ production but also by its degradation. One of the proteases involved in the degradation of A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae22b7f2392391714cf275a7f46ed0c
https://doi.org/10.1038/mt.2008.148
https://doi.org/10.1038/mt.2008.148
Deglycosylated Anti-Aβ Antibody Dose–Response Effects on Pathology and Memory in APP Transgenic Mice
Autor:
Marcia N. Gordon, Jaume Pons, Arnon Rosenthal, Dave Morgan, Victoria Ronan, Paul E. Gottschall, Rachel Karlnoski, Jennifer Alamed, Grimm Jan Markus
Publikováno v:
Journal of Neuroimmune Pharmacology. 3:187-197
Anti-Abeta antibody administration to amyloid-depositing transgenic mice can reverse amyloid pathology and restore memory function. However, in old mice, these treatments also increase vascular leakage and promote formation of vascular amyloid deposi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d74964988d357449a717c7f2f46283e1
https://doi.org/10.1007/s11481-008-9114-6
https://doi.org/10.1007/s11481-008-9114-6
Publikováno v:
Journal of Neuroscience Research. 86:1106-1114
The developing brain is uniquely susceptible to injury after exposure to hypoxia-ischemia (H-I). Lecticans are developmentally regulated in formative white matter and exert growth-inhibitory effects in several adult injury models, yet little is known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc46fb1d628b8f1f3e1d2f0e19b4a36f
https://doi.org/10.1002/jnr.21553
https://doi.org/10.1002/jnr.21553
Autor:
John D. Sandy, Christopher C. Leonardo, Michelle G. Hamel, Paul E. Gottschall, Fengrong Zuo, Joanne M. Ajmo
Publikováno v:
Experimental Neurology. 210:428-440
Aggregating proteoglycans (PG) bearing chondroitin sulfate (CS) side chains associate with hyaluronan and various secreted proteins to form a complex of extracellular matrix (ECM) that inhibits neural plasticity in the central nervous system (CNS). C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a7340718a5475d170337a31a82842ba
https://doi.org/10.1016/j.expneurol.2007.11.014
https://doi.org/10.1016/j.expneurol.2007.11.014
Publikováno v:
Biophysical Chemistry. 129:224-234
Efficient determination of three-dimensional protein structures is critical for unraveling structure-function relationships and for supporting targeted drug design. A major impediment to these efforts is our lack of control over the nucleation and gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1085c017db15ea48b8f7654b7901c38
https://doi.org/10.1016/j.bpc.2007.06.002
https://doi.org/10.1016/j.bpc.2007.06.002
Publikováno v:
Acta Neuropathologica Communications
Introduction Substantial data has shown that the lectican group of chondroitin sulfate proteoglycans are involved in inhibition of axonal plasticity in response to injury in the central nervous system. Increasing evidence indicates that lecticans may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c1d8504e2cecfc64b7d149d50884b9e
https://doi.org/10.1186/s40478-015-0233-z
https://doi.org/10.1186/s40478-015-0233-z