Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Paul E. Fagerness"'
Publikováno v:
Journal of the American Chemical Society. 125:7696-7703
Competition ligand-based NMR screening experiments have recently been introduced to overcome most of the problems associated with traditional ligand-based NMR screening. Molecules with marginal solubility and high affinity for a given target can be e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e8077f6396be083be87ba82d20f6d7
https://doi.org/10.1021/ja034646d
https://doi.org/10.1021/ja034646d
Autor:
Paul E Fagerness, Michael Barfield and
Publikováno v:
Journal of the American Chemical Society. 119:8699-8711
The dependence of the 13C, 15N, and 1H isotropic NMR chemical shifts on amine substitution of aromatic ring systems are examined both experimentally and by DFT/GIAO (density functional theory/gauge including atomic orbitals) methods. There are large,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ec9d9696db763812c86f79483c3f0f8
https://doi.org/10.1021/ja970990x
https://doi.org/10.1021/ja970990x
Autor:
Ping Gao, Paul E. Fagerness
Publikováno v:
Pharmaceutical Research. 12:955-964
Purpose. This work describes diffusivity measurements of drug (adinazolam mesylate) and water in a variety of solutions including polymer gels.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a21e1c31c53e988819bc82dc8cddbcd
https://doi.org/10.1023/a:1016293911499
https://doi.org/10.1023/a:1016293911499
Publikováno v:
Pharmaceutical Research. 10:75-79
Understanding how moisture interacts with a drug or formulation is a critical component of product development. This study demonstrates how water affects the 3′-gem-diol ↔ 3′-keto equilibrium in trospectomycin sulfate bulk drug and freeze-dried
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1e032c9a34c758a8a8bb6e32d06ccaa
https://doi.org/10.1023/a:1018925113721
https://doi.org/10.1023/a:1018925113721
Publikováno v:
Biochemical Journal. 194:627-631
The facultative anaerobes Rhodopseudomonas spheroides and Propionibacterium shermanii were grown under anaerobic and aerobic conditions. The effect of light was studied with the photosynthetic R. spheroides, and the adaptation of both species to dark
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb7a561a58f2d84f2c98a54e4efa3ce6
https://doi.org/10.1042/bj1940627
https://doi.org/10.1042/bj1940627
Publikováno v:
Tetrahedron. 36:2721-2725
Due to their sensitivity to light and air, porphyrinogens are not normally isolated, but are routinely analyzed by oxidation to the corresponding porphyrin. We report herein the 13 C- and 15 N-NMR spectra of uroporphyrinogens I and III in their “na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::856c8f85f06bbd2333ae95abeed80e5d
https://doi.org/10.1016/0040-4020(80)80147-5
https://doi.org/10.1016/0040-4020(80)80147-5
Publikováno v:
The Journal of Organic Chemistry. 43:828-834
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10afcfb37654ae8d44ea42566a7d2c76
https://doi.org/10.1021/jo00399a008
https://doi.org/10.1021/jo00399a008
Publikováno v:
J. Chem. Soc., Perkin Trans. 2. :1586-1591
A series of v-triazolo[4,5-b]pyridine nucleosides, which are structurally related to the biologically active 8-azapurines, has been prepared. The use of natural abundance carbon-13 n.m.r. in establishing the site of ribosylation of the nucleoside 5-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a51929e2db50d9ae299b061595042d7
https://doi.org/10.1039/p29800001586
https://doi.org/10.1039/p29800001586
Autor:
Yi Jin Jang, N. E. Mackenzie, J P G Malthouse, A. Brisson, Le Zong Qi, Paul E. Fagerness, A. I. Scott, Carl M. Carter, W. U. Primrose, W. Bode
Publikováno v:
Tetrahedron. 42:3269-3276
Comparison of the X-ray diffraction data and both solution and solid (CPMAS) NMR spectra for the covalent adduct of trypsin and carbobenzyloxylysyl chloromethyl ketone provides unequivocal evidence that the serine-195 hydroxyl group of the enzyme for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c123b55204f2966710d4d95a4ca2910
https://doi.org/10.1016/s0040-4020(01)87391-9
https://doi.org/10.1016/s0040-4020(01)87391-9
Autor:
John Y. Lee, Philip J. Sidebottom, Gerardo Burton, Kozo Shishido, Paul E. Fagerness, A. Ian Scott, Robert Baxter, J. Martyn Gunn
Publikováno v:
Canadian Journal of Chemistry. 58:1839-1846
Applications of 13C nmr in following the metabolism and fate of 13C enriched substrates in whole cells are described. Studies on the elaboration of coproporphyrinogens I (2a) and III (2b) from [5-13C]-δ-aminolevulinic acid (1) and [11-13C-porphobili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a3bb7c0c36712df3c07a841cd9adecb
https://doi.org/10.1139/v80-289
https://doi.org/10.1139/v80-289