Výsledky vyhledávání - "Paul E. Blower"

Data from MicroRNAs modulate the chemosensitivity of tumor cells

Autor: Wolfgang Sadee, John N. Weinstein, Carlo M. Croce, William C. Reinhold, Thomas D. Schmittgen, Chang-Gong Liu, Zunyan Dai, Jong-Kook Park, Shili Lin, Joseph S. Verducci, Ji-Hyun Chung, Paul E. Blower

MicroRNAs are strongly implicated in such processes as development, carcinogenesis, cell survival, and apoptosis. It is likely, therefore, that they can also modulate sensitivity and resistance to anticancer drugs in substantial ways. To test this hy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b43caabd7dc82c1d831746a9f3b6d81
https://doi.org/10.1158/1535-7163.c.6532169

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Data from MicroRNA expression profiles for the NCI-60 cancer cell panel

Autor: Wolfgang Sadee, John N. Weinstein, Carlo M. Croce, Eric P. Kaldjian, Philip L. Lorenzi, William Reinhold, Chang-Gong Liu, Zunyan Dai, Ji-Hyun Chung, Jin Zhou, Shili Lin, Joseph S. Verducci, Paul E. Blower

Advances in the understanding of cancer cell biology and response to drug treatment have benefited from new molecular technologies and methods for integrating information from multiple sources. The NCI-60, a panel of 60 diverse human cancer cell line

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4237de8edcffaf450c2b3a4d19da6578
https://doi.org/10.1158/1535-7163.c.6531822.v1

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The tau-path test for monotone association in an unspecified subpopulation: Application to chemogenomic data mining

Autor: Joseph S. Verducci, Li Yu, Paul E. Blower

Publikováno v: Statistical Methodology. 8:97-111

In data mining and other settings, there is sometimes a need to identify relationships between variables when the relationship may hold only over a subset of the observations available. For example, expression of a particular gene may cause resistanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::50523e8ce8c6e2094f55f9f732c8215f
https://doi.org/10.1016/j.stamet.2010.01.006

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Pharmacogenomic Approach Reveals a Role for the xc−Cystine/Glutamate Antiporter in Growth and Celastrol Resistance of Glioma Cell Lines

Autor: Ying Huang, Omar Alvarado, Anh-Nhan Pham, Paul E. Blower, Ranadheer Ravula, Peter W. Gout

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 332:949-958

The x c − cystine/glutamate antiporter has been implicated in GSH-based chemoresistance because it mediates cellular uptake of cystine/cysteine for sustenance of intracellular GSH levels. Celastrol, isolated from a Chinese medicinal herb, is a nove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac3ec772a9872684eac402123983bdf
https://doi.org/10.1124/jpet.109.162248

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In vitro differential sensitivity of melanomas to phenothiazines is based on the presence of codon 600 BRAF mutation

Autor: Michael R. Stratton, Paul E. Blower, Mark Reimers, Ogechi Ikediobi, John N. Weinstein, Steffen Durinck, Andrew Futreal

Publikováno v: Molecular Cancer Therapeutics. 7:1337-1346

The panel of 60 human cancer cell lines (the NCI-60) assembled by the National Cancer Institute for anticancer drug discovery is a widely used resource. We previously sequenced 24 cancer genes in those cell lines. Eleven of the genes were found to be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609b685c0c6d5247f428a86b1314aa7d
https://doi.org/10.1158/1535-7163.mct-07-2308

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Correlating gene expression with chemical scaffolds of cytotoxic agents: ellipticines as substrates and inhibitors of MDR1

Autor: Zunyan Dai, C Yang, Ying Huang, Y Zhang, Catalin Barbacioru, Wolfgang Sadee, K K Chan, Paul E. Blower, J J Xiao

Publikováno v: The Pharmacogenomics Journal. 5:112-125

To facilitate a systematic study of chemoresistance across diverse classes of anticancer drug candidates, we performed correlation analyses between cytotoxic drug potency and gene expression in 60 tumor cell lines (NCI-60; NCI-National Cancer Institu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7105a62069ef4176791a3abf5ed37b6c
https://doi.org/10.1038/sj.tpj.6500297

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Building Predictive Models for Protein Tyrosine Phosphatase 1B Inhibitors Based on Discriminating Structural Features by Reassembling Medicinal Chemistry Building Blocks

Autor: Glenn J. Myatt, Paul E. Blower, Chihae Yang, James F. Rathman, Kevin P. Cross

Publikováno v: Journal of Medicinal Chemistry. 47:5984-5994

A new approach to predicting the biological activity of small molecule pharmaceutics is demonstrated. Structural features of medicinal chemistry building blocks are used as 2-D molecular descriptors. These descriptors include predefined structural fe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eddabea670ef6414bbe4de31081f72f
https://doi.org/10.1021/jm0497242

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