Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Paul E. Barkhaus"'
Motor Neuron Generation from iPSCs from Identical Twins Discordant for Amyotrophic Lateral Sclerosis
Autor:
Emily R. Seminary, Stephanie Santarriaga, Lynn Wheeler, Marie Mejaki, Jenica Abrudan, Wendy Demos, Michael T. Zimmermann, Raul A. Urrutia, Dominic Fee, Paul E. Barkhaus, Allison D. Ebert
Publikováno v:
Cells, Vol 9, Iss 3, p 571 (2020)
Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disorder characterized by the loss of the upper and lower motor neurons. Approximately 10% of cases are caused by specific mutations in known genes, with the remaining cases having no
Externí odkaz:
https://doaj.org/article/093317604a7548b89da66bc393e6a3f4
Publikováno v:
Clinical Neurophysiology. 139:119-127
The compound muscle action potential (CMAP) scan is useful to study motor unit (MU) loss. It is of interest to develop simple measurements of the scan.CMAP scan recordings were performed in the abductor pollicis brevis muscle of 20 control subjects a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12973d9adeae3638b7f56581f205260e
https://doi.org/10.1016/j.clinph.2022.04.011
https://doi.org/10.1016/j.clinph.2022.04.011
Autor:
Sanjeev D. Nandedkar, Paul E. Barkhaus
Publikováno v:
Musclenerve.
Low amplitude compound muscle action potential (CMAP) suggests a neuromuscular pathology. Low amplitude will also result from a defective E1 electrode or its lead, i.e. a technical artifact. The aim of this study was to investigate the effect of a de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e535b962d72ebf9b5818d09e5817255
https://pubmed.ncbi.nlm.nih.gov/36605021
https://pubmed.ncbi.nlm.nih.gov/36605021
Autor:
Tulio E. Bertorini, Christopher J McDermott, Isaac Lund, Steven Novella, Gleb Levitsky, Gregory T. Carter, Ce Jackson, Merit Cudkowicz, Lyle Ostrow, Vinay Chaudry, Anne-Marie Wills, Kristiana Salmon, Richard Bedlack, Morgan Beauchamp, Mark B. Bromberg, Terry Heiman-Patterson, Dylan Ratner, Natasha J. Olby, Benjamin Barnes, Paul E. Barkhaus, Paul Wicks, Mark Terrelonge, Susan Steves, Gary L. Pattee
Publikováno v:
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 24:159-163
ALSUntangled reviews alternative and off label treatments with a goal of helping patients make more informed decisions about them. Here we review ketogenic diets. We shows that these have plausible mechanisms, including augmenting cellular energy bal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ed9a3e70117633aca94ada86c7098f
https://doi.org/10.1080/21678421.2021.1990346
https://doi.org/10.1080/21678421.2021.1990346
Publikováno v:
MusclenerveREFERENCES. 66(6)
A prevailing concept of motor unit (MU) recruitment used for calculating recruitment ratio (RR) suggests a progressive linear increase in firing rate (FR). The objective of this study is to assess its validity.Concentric needle electromyography (EMG)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df5b81ff45d3f648c5a56bfdff6b3dce
https://pubmed.ncbi.nlm.nih.gov/36214178
https://pubmed.ncbi.nlm.nih.gov/36214178
Autor:
Meraida Polak, Greg Carter, Kristiana Salmon, Richard Bedlack, Paul Wicks, Paul E. Barkhaus, Christopher J McDermott, Jesse Crayle, Gary L. Pattee
Publikováno v:
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 23:476-479
Vitamin C is one of the most common supplements taken by people with ALS. As an antioxidant, it has a plausible mechanism for slowing disease progression and there are some flawed pre-clinical studies and case reports suggesting benefit. However, a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df3d14077af3f1fe75516871e5b47010
https://doi.org/10.1080/21678421.2021.1946088
https://doi.org/10.1080/21678421.2021.1946088
Publikováno v:
Muscle & Nerve. 64:86-89
Introduction/aims The virtual cathode (VC) is a site near the anode where the nerve can be stimulated. Costimulation of neighboring nerves via the VC can affect recording and interpretation of responses. Hence, it is important to teach trainees the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced2d3e8ed0ee3629b43bc377a41da58
https://doi.org/10.1002/mus.27246
https://doi.org/10.1002/mus.27246
Publikováno v:
Muscle & Nerve. 63:737-744
INTRODUCTION In this study we describe a method called "multivariable extrapolated reference values" (MeRef) that derives reference values (RVs) using patient data and includes the dependence of these variables on multiple patient demographic variabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::685057e0e56fcd0ebac4334df1123ba3
https://doi.org/10.1002/mus.27195
https://doi.org/10.1002/mus.27195
Autor:
Michael S. Bereman, Terry Heiman Patterson, Paul Wicks, Paul E. Barkhaus, Kristiana Salmon, Richard Bedlack, James B. Caress, Sky Kihuwa-mani, Gregory T. Carter, Gary L. Pattee, Neta Zach, Jesse Crayle
Publikováno v:
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 22:595-598
Here we use the ALSUntangled methodology to review Tamoxifen as an ALS treatment. We show that it has plausible mechanisms, a positive preclinical study, a case report and 2 small trials suggesting benefits. We show that it appears reasonably safe, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::645635478b5b50e6b77efc4a4cbcabc7
https://doi.org/10.1080/21678421.2021.1876731
https://doi.org/10.1080/21678421.2021.1876731
Publikováno v:
Muscle & Nerve. 62:233-238
Introduction In contrast to needle electromyography (EMG), surface EMG recordings are painless. It is of interest to develop methods to analyze surface EMG for diagnostic purposes. Methods Surface EMG interference pattern (SIP) recordings from the ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198df8d7ff28802b119c1e5882e53101
https://doi.org/10.1002/mus.26922
https://doi.org/10.1002/mus.26922