Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Paul E Thomas"'
Autor:
Chung S. Yang, Mao-Jung Lee, Joseph Wahler, Brian A. Wall, Paul E. Thomas, Nanjoo Suh, Jae Young So, Soumyasri Das Gupta, Sudathip Sae-tan, Haixiang Yu, Amanda K. Smolarek, Kelvin Y. Soewono
Publikováno v:
Molecular Carcinogenesis. 54:916-925
Oxidative stress is known to play a key role in estrogen-induced breast cancer. This study assessed the chemopreventive activity of the naturally occurring γ-tocopherol-rich mixture of tocopherols (γ-TmT) in early stages of estrogen-induced mammary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf6b4984cc5a08e511aea7ad939fda2d
https://doi.org/10.1002/mc.22164
https://doi.org/10.1002/mc.22164
Autor:
Chung S. Yang, Mao Jung Lee, Ah-Ng Tony Kong, Kenneth R. Reuhl, Paul E. Thomas, Tin Oo Khor, Constance Lay Lay Saw, Shiby Paul, Anne Dombrowski, Hong Jin Lee, Chung Xiou Wang, Jae Young So, Amanda K. Smolarek, Nanjoo Suh
Publikováno v:
Molecular Carcinogenesis. 52:514-525
Previous clinical and epidemiological studies of vitamin E have used primarily α-tocopherol for the prevention of cancer. However, γ-tocopherol has demonstrated greater anti-inflammatory and anti-tumor activity than α-tocopherol in several animal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::391dbcd118a3b2e6a6dc81265a751846
https://doi.org/10.1002/mc.21886
https://doi.org/10.1002/mc.21886
Publikováno v:
Drug Metabolism and Disposition. 40:481-485
Genistein is a natural phytoestrogen of the soybean, and bisphenol A (BPA) is a synthetic chemical used in the production of polycarbonate plastics. Both genistein and BPA disrupt the endocrine system in vivo and in vitro. Growing concerns of altered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b000e9b54393db1562212f203ff9196
https://doi.org/10.1124/dmd.111.042366
https://doi.org/10.1124/dmd.111.042366
Autor:
Hong Jin Lee, Xi Zheng, Milan R. Uskokovic, Nanjoo Suh, Brian Buckley, Ill Yang, Xinjie Lin, Shiby Paul, You Rong Lou, Nadi Atalla, Allan H. Conney, Luciano Adorini, Hubert Maehr, Gang Lu, Paul E. Thomas
Publikováno v:
Cancer Prevention Research. 1:476-484
Numerous preclinical, epidemiologic, and clinical studies have suggested the benefits of vitamin D and its analogues for the prevention and treatment of cancer. However, the hypercalcemic effects have limited the use of 1α,25(OH)2D3, the hormonally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51cf66924424e870c122c9c018dbc28
https://doi.org/10.1158/1940-6207.capr-08-0084
https://doi.org/10.1158/1940-6207.capr-08-0084
Autor:
Michael A. Gallo, Duan Liu, Sui Ke, Yanan Tian, Arnold B. Rabson, Xinsheng Gu, Wen Xie, Tao Sheng, Paul E. Thomas
Publikováno v:
Journal of Biological Chemistry. 281:17882-17889
It is a long-standing observation that inflammatory responses and infections decrease drug metabolism capacity in human and experimental animals. Cytochrome P-450 3A4 cyp304 is responsible for the metabolism of over 50% of current prescription drugs,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::215b011b1a2a11826acbf1fa38736638
https://doi.org/10.1074/jbc.m601302200
https://doi.org/10.1074/jbc.m601302200
Publikováno v:
Archives of Biochemistry and Biophysics. 446:101-110
The purpose of this study was to identify isozyme-specific antibodies and use them to determine the expression levels of four P450 3A enzymes in the livers of vehicle- and pregnenolone 16alpha-carbonitrile (PCN)-treated rats of both sexes, since prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9f7cb56a4657c56dfe44cc732c57a2d
https://doi.org/10.1016/j.abb.2005.11.019
https://doi.org/10.1016/j.abb.2005.11.019
Publikováno v:
Archives of Biochemistry and Biophysics. 429:244-251
Enterolactone (ENL) and enterodiol (END) are mammalian lignans derived from the plant lignans matairesionol (MAT), secoisolariciresinol (SECO), and other dietary precursors. ENL was found to undergo extensive glucuronidation with rhesus liver microso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45a4cf673d335e76037fab9d13d17beb
https://doi.org/10.1016/j.abb.2004.06.023
https://doi.org/10.1016/j.abb.2004.06.023
Autor:
Vladimir Mishin, Paul E. Thomas
Publikováno v:
Biochemical Pharmacology. 68:747-752
Using terephthalic acid as a water-soluble trap, we characterized hydroxyl radicals (HO?) formation by liver microsomal enzymes from isoniazid-treated rats. We found that HO? formation was entirely dependent on intact microsomal enzymes, the presence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3df380fc34e89bad3e86253b237495
https://doi.org/10.1016/j.bcp.2004.05.004
https://doi.org/10.1016/j.bcp.2004.05.004
Publikováno v:
Endocrinology. 144:3382-3398
We systematically characterized the oxidative metabolites of 17beta-estradiol and estrone formed by 15 human cytochrome P450 (CYP) isoforms. CYP1A1 had high activity for 17beta-estradiol 2-hydroxylation, followed by 15alpha-, 6alpha-, 4-, and 7alpha-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d66f6e4e3c6fc5fdc2c925abb178457f
https://doi.org/10.1210/en.2003-0192
https://doi.org/10.1210/en.2003-0192
Stimulatory effect of cigarette smoking on the 15α-hydroxylation of estradiol by human term placenta
Autor:
George H Lambert, Bao Ting Zhu, Yu-Ling Lai, David C. Spink, Paul E. Thomas, May Xiaoxin Cai, Angela C. Ranzini, Christine M. Busch, Mirza M. Hussain, Allan H. Conney
Publikováno v:
Clinical Pharmacology & Therapeutics. 71:311-324
Objective Our objective was to characterize the oxidative metabolism of estradiol by human term placenta and its modulation by cigarette smoking. Methods Placental microsomes were prepared from term placentas obtained from 13 cigarette smokers (20 to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1f4063a03f4564ae58658d8c854e39
https://doi.org/10.1067/mcp.2002.122500
https://doi.org/10.1067/mcp.2002.122500