Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Paul E Oran"'
Autor:
Paul E Oran, Olgica Trenchevska, Dobrin Nedelkov, Chad R Borges, Matthew R Schaab, Douglas S Rehder, Jason W Jarvis, Nisha D Sherma, Luhui Shen, Bryan Krastins, Dawn C Schwenke, Peter D Reaven, Randall W Nelson
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92801 (2014)
Insulin-like growth factor 1 (IGF1) is an important biomarker for the management of growth hormone disorders. Recently there has been rising interest in deploying mass spectrometric (MS) methods of detection for measuring IGF1. However, widespread cl
Externí odkaz:
https://doaj.org/article/bb85b97f782f4818917849d3347eec55
Publikováno v:
Journal of Proteomics. 175:27-33
Measurement of insulin and its therapeutic analogs is important in diabetes, hypoglycemia, sports anti-doping and toxicology. Commercial insulin immunoassays fail to detect commonly prescribed insulin analogs. Because of their unique sequences and ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::533d65a57b659919e007b62ac7866d94
https://doi.org/10.1016/j.jprot.2017.08.001
https://doi.org/10.1016/j.jprot.2017.08.001
Autor:
Alessandra Luchini, Andrei P. Drabovich, Vathany Kulasingam, Bryan Krastins, Randall W. Nelson, Ihor Batruch, Daniel W. Chan, Paul E. Oran, Mary F. Lopez, Yuan Tian, Amol Prakash, David A. Sarracino, Claudia Fredolini, Christopher R. Smith, Taha Rezai, Yan Li, Paul Russo, Hui Zhang, Emanuel F. Petricoin, Michael Athanas, Eleftherios P. Diamandis, Lance A. Liotta
Publikováno v:
Journal of Proteome Research. 11:3986-3995
Over the past few years, mass spectrometry has emerged as a technology to complement and potentially replace standard immunoassays in routine clinical core laboratories. Application of mass spectrometry to protein and peptide measurement can provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaa4cc8c193ca1b6c82ae01d0ecb8b1b
https://doi.org/10.1021/pr300014s
https://doi.org/10.1021/pr300014s
Publikováno v:
PROTEOMICS - Clinical Applications. 5:454-459
Purpose: The purpose of the work presented herein was to develop a high-throughput assay for the quantification of human insulin in plasma samples while simultaneously detecting, with high mass accuracy, any additional variant forms of insulin that m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7d6c51dbd5ce9043707758ff669b738
https://doi.org/10.1002/prca.201000112
https://doi.org/10.1002/prca.201000112
Autor:
Sai Buddi, Douglas S. Rehder, Chad R. Borges, Randall W. Nelson, Matthew R. Schaab, Thomas J. Taylor, Paul E. Oran, Jason W. Jarvis, Stephen P Rogers
Publikováno v:
Clinical Chemistry. 57:719-728
BACKGROUNDIn 2008, the US Food and Drug Administration (FDA) issued a Guidance for Industry statement formally recognizing (during drug development) the conjoined nature of type 2 diabetes (T2D) and cardiovascular disease (CVD), which has precipitate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d242deee58f2c908e3dba492dee1187
https://doi.org/10.1373/clinchem.2010.156976
https://doi.org/10.1373/clinchem.2010.156976
Publikováno v:
Clinical Chemistry. 56:1432-1441
BACKGROUNDCurrent immunoassays for the chemokine RANTES (regulated on activation, normal T-cell expressed and secreted) are not tailored for specific isoforms that exist endogenously, despite the fact that variants with modified activity are known to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d52467ecd230fcb7f9f320b0eeda754
https://doi.org/10.1373/clinchem.2010.147884
https://doi.org/10.1373/clinchem.2010.147884
Autor:
Paul E. Oran, Randall W. Nelson, Douglas S. Rehder, Jason W. Jarvis, Chad R. Borges, Olgica Trenchevska, Dobrin Nedelkov, Nisha D. Sherma
Publikováno v:
Proteome Science
Background The cytokine MIF (Macrophage Migration Inhibitory Factor) has diverse physiological roles and is present at elevated concentrations in numerous disease states. However, its molecular heterogeneity has not been previously investigated in bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec8d8418f13bda3a2769b9e704d8369
https://doi.org/10.1186/s12953-014-0052-3
https://doi.org/10.1186/s12953-014-0052-3
Autor:
Peter D. Reaven, Olgica Trenchevska, Paul E. Oran, Dobrin Nedelkov, Nisha D. Sherma, Randall W. Nelson
Publikováno v:
Journal of proteomics. 116
The chemokine RANTES plays a key role in inflammation, cell recruitment and T cell activation. RANTES is heterogenic and exists as multiple variants in vivo. Herein we describe the development and characterization of a fully quantitative mass spectro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c92f4c89ea15053e71b15c1c073d282f
https://pubmed.ncbi.nlm.nih.gov/25549571
https://pubmed.ncbi.nlm.nih.gov/25549571
Autor:
Bryan Krastins, David R. Barnidge, Amol Prakash, Ravinder J. Singh, David A. Sarracino, Paul E. Oran, Chad R. Borges, Taha Rezai, Mary F. Lopez, Randall W. Nelson, Michael Athanas
Publikováno v:
Clinical chemistry. 56(2)
Background: Parathyroid hormone (PTH) assays able to distinguish between full-length PTH (PTH1–84) and N-terminally truncated PTH (PTH7–84) are of increasing significance in the accurate diagnosis of endocrine and osteological diseases. We descri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16cda71bb557c660c4499ce55074bb06
https://pubmed.ncbi.nlm.nih.gov/20022981
https://pubmed.ncbi.nlm.nih.gov/20022981
Autor:
Jason W. Jarvis, Randall W. Nelson, Paul E. Oran, Mathew R. Schaab, Doug S. Rehder, Chad R. Borges
Publikováno v:
Clinical chemistry. 56(2)
Background: Diversity in human proteins often gives rise to pluralities of structurally similar but functionally distinct proteins. Such microheterogeneity generally escapes proteomics discovery technologies, as well as conventional immunometric assa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a8ff14d4d8c8c3e036d3e1a5ce8597
https://pubmed.ncbi.nlm.nih.gov/19926773
https://pubmed.ncbi.nlm.nih.gov/19926773