Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Paul E Hardin"'
Publikováno v:
PLoS Genetics, Vol 12, Iss 11, p e1006430 (2016)
The Drosophila circadian oscillator controls daily rhythms in physiology, metabolism and behavior via transcriptional feedback loops. CLOCK-CYCLE (CLK-CYC) heterodimers initiate feedback loop function by binding E-box elements to activate per and tim
Externí odkaz:
https://doaj.org/article/5ca9bf9b2a754ca7b4fa7a8fb4a747c8
Autor:
Euna Lee, Eun Hee Jeong, Hyun-Jeong Jeong, Evrim Yildirim, Jens T Vanselow, Fanny Ng, Yixiao Liu, Guruswamy Mahesh, Achim Kramer, Paul E Hardin, Isaac Edery, Eun Young Kim
Publikováno v:
PLoS Genetics, Vol 10, Iss 8, p e1004545 (2014)
Transcriptional/translational feedback loops drive daily cycles of expression in clock genes and clock-controlled genes, which ultimately underlie many of the overt circadian rhythms manifested by organisms. Moreover, phosphorylation of clock protein
Externí odkaz:
https://doaj.org/article/b9ee126a535845b2a6e59d33593f6fe2
Publikováno v:
PLoS Genetics, Vol 3, Iss 1, p e16 (2007)
Mating behavior in Drosophila depends critically on the sexual identity of specific regions in the brain, but several studies have identified courtship genes that express products only outside the nervous system. Although these genes are each active
Externí odkaz:
https://doaj.org/article/92b56bcea75a44d1bb7c9c6d07121005
Publikováno v:
Frontiers in Systems Neuroscience, Vol 17 (2023)
The role of the circadian system in memory formation is an important question in neurobiology. Despite this hypothesis being intuitively appealing, the existing data is confusing. Recent work in Drosophila has helped to clarify certain aspects of the
Externí odkaz:
https://doaj.org/article/fec470b0d8c345ff91f811c1758a20a8
Publikováno v:
Curr Biol
Summary The Drosophila circadian clock is driven by a transcriptional feedback loop in which CLOCK-CYCLE (CLK-CYC) binds E-boxes to transcribe genes encoding the PERIOD-TIMELESS (PER-TIM) repressor, which releases CLK-CYC from E-boxes to inhibit tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8351cc4edfe41cca3dcbbe7c330274
https://europepmc.org/articles/PMC8511158/
https://europepmc.org/articles/PMC8511158/
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101893-(2021)
Summary The vrille (vri) gene encodes a transcriptional repressor required for Drosophila development as well as circadian behavior in adults. Alternate first exons produce vri transcripts predicted to produce a short VRI isoform during development a
Autor:
David L. Allen, Guruswamy Mahesh, Richard A. L. Jones, Courtney Caster, Evan B Ost, Ravi Amunugama, Gustavo B. S. Rivas, Paul E. Hardin
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Circadian clocks keep time via ~ 24 h transcriptional feedback loops. In Drosophila, CLOCK-CYCLE (CLK-CYC) activators and PERIOD-TIMELESS (PER-TIM) repressors are feedback loop components whose transcriptional status varies over a circadian cycle. Al
Publikováno v:
iScience
Summary The vrille (vri) gene encodes a transcriptional repressor required for Drosophila development as well as circadian behavior in adults. Alternate first exons produce vri transcripts predicted to produce a short VRI isoform during development a
Publikováno v:
Neurobiology of Sleep and Circadian Rhythms
Neurobiology of Sleep and Circadian Rhythms, Vol 5, Iss, Pp 58-67 (2018)
Neurobiology of Sleep and Circadian Rhythms, Vol 5, Iss, Pp 58-67 (2018)
In the early 1980s Jeff Hall and Michael Rosbash at Brandeis University and Mike Young at Rockefeller University set out to isolate the period (per) gene, which was recovered in a revolutionary genetic screen by Ron Konopka and Seymour Benzer for mut
Autor:
Paul E. Hardin, Parul Agrawal
Publikováno v:
G3: Genes|Genomes|Genetics
G3: Genes, Genomes, Genetics, Vol 6, Iss 12, Pp 4227-4238 (2016)
G3: Genes, Genomes, Genetics, Vol 6, Iss 12, Pp 4227-4238 (2016)
Circadian clocks in eukaryotes keep time via cell-autonomous transcriptional feedback loops. A well-characterized example of such a transcriptional feedback loop is in Drosophila, where CLOCK-CYCLE (CLK-CYC) complexes activate transcription of period