Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding

Autor: Paul E Chappell, El Kahina Meziane, Michael Harrison, Łukasz Magiera, Clemens Hermann, Laura Mears, Antoni G Wrobel, Charlotte Durant, Lise Lotte Nielsen, Søren Buus, Nicola Ternette, William Mwangi, Colin Butter, Venugopal Nair, Trudy Ahyee, Richard Duggleby, Alejandro Madrigal, Pietro Roversi, Susan M Lea, Jim Kaufman

Publikováno v: eLife, Vol 4 (2015)

Highly polymorphic major histocompatibility complex (MHC) molecules are at the heart of adaptive immune responses, playing crucial roles in many kinds of disease and in vaccination. We report that breadth of peptide presentation and level of cell sur

Externí odkaz: https://doaj.org/article/401c28ae24f148d385a2c6b49fd379e2

Mechanism of Thiosulfate Oxidation in the SoxA Family of Cysteine-ligated Cytochromes

Autor: Bianca Eisel, Ben C. Berks, Susan M. Lea, Steven Johnson, Daniel B. Grabarczyk, Paul E. Chappell

Publikováno v: The Journal of Biological Chemistry

Background: The hemoprotein TsdA catalyzes the oxidation of two thiosulfate molecules to form tetrathionate. Results: The mechanism of TsdA has been probed using biochemical and structural methods. Conclusion: The TsdA reaction proceeds via a cystein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00d40ce20068448e83d5adbe296f4d9
https://doi.org/10.1074/jbc.m114.618025

Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding

Autor: James C. Kaufman, C. Butter, Charlotte Durant, Clemens Hermann, Susan M. Lea, Paul E. Chappell, Laura Mears, Alejandro Madrigal, Pietro Roversi, William Mwangi, Łukasz Magiera, Venugopal Nair, A.G. Wrobel, El Kahina Meziane, Michael Harrison, Nicola Ternette, Søren Buus, Trudy Ahyee, Lise Lotte Nielsen, Richard Duggleby

Publikováno v: eLife
Chappell, P E, Meziane, E K, Harrison, M, Magiera, Ł, Hermann, C, Mears, L, Wrobel, A G, Durant, C, Nielsen, L L, Buus, S, Ternette, N, Mwangi, W, Butter, C, Nair, V, Ahyee, T, Duggleby, R, Madrigal, A, Roversi, P, Lea, S M & Kaufman, J 2015, ' Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding ', eLIFE, vol. 4, e05345 . https://doi.org/10.7554/eLife.05345
'eLife ', vol: 4, pages: e05345-1-e05345-22 (2015)
eLife, Vol 4 (2015)

Highly polymorphic major histocompatibility complex (MHC) molecules are at the heart of adaptive immune responses, playing crucial roles in many kinds of disease and in vaccination. We report that breadth of peptide presentation and level of cell sur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f2c8367cbb789814503b0acf5cc922
https://www.repository.cam.ac.uk/handle/1810/248451

Structural basis for specificity and promiscuity in a carrier protein/enzyme system from the sulfur cycle

Autor: Paul E. Chappell, Ben C. Berks, Lukas S. Stelzl, Susan M. Lea, Daniel B. Grabarczyk, Steven Johnson

Publikováno v: Proceedings of the National Academy of Sciences.

The bacterial Sox (sulfur oxidation) pathway is an important route for the oxidation of inorganic sulfur compounds. Intermediates in the Sox pathway are covalently attached to the heterodimeric carrier protein SoxYZ through conjugation to a cysteine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a940302425067aacbf0d14bc787f9687
http://ora.ox.ac.uk/objects/uuid:80248819-f533-4239-aacd-cd6a7f5ce760