Výsledky vyhledávání - "Paul E, Sawchenko"

Akademický článek

The Rat Mammary Gland as a Novel Site of Expression of Melanin-Concentrating Hormone Receptor 1 mRNA and Its Protein Immunoreactivity

Autor: Daniella S. Battagello, Aline R. Lorenzon, Giovanne B. Diniz, Lívia C. Motta-Teixeira, Marianne O. Klein, Jozélia G. P. Ferreira, Carlos M. Arias, Antoine Adamantidis, Luciane V. Sita, José Cipolla-Neto, Estela M. A. F. Bevilacqua, Paul E. Sawchenko, Jackson C. Bittencourt

Publikováno v: Frontiers in Endocrinology, Vol 11 (2020)

Lactation is a complex physiological process, depending on orchestrated central and peripheral events, including substantial brain plasticity. Among these events is a novel expression of pro-melanin-concentrating hormone (Pmch) mRNA in the rodent hyp

Externí odkaz: https://doaj.org/article/03ac83c64669467b9423788cf8beadf2

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Akademický článek

The anorectic actions of the TGFβ cytokine MIC-1/GDF15 require an intact brainstem area postrema and nucleus of the solitary tract.

Autor: Vicky Wang-Wei Tsai, Rakesh Manandhar, Sebastian Beck Jørgensen, Ka Ki Michelle Lee-Ng, Hong Ping Zhang, Christopher Peter Marquis, Lele Jiang, Yasmin Husaini, Shu Lin, Amanda Sainsbury, Paul E Sawchenko, David A Brown, Samuel N Breit

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e100370 (2014)

Macrophage inhibitory cytokine-1 (MIC-1/GDF15) modulates food intake and body weight under physiological and pathological conditions by acting on the hypothalamus and brainstem. When overexpressed in disease, such as in advanced cancer, elevated seru

Externí odkaz: https://doaj.org/article/5e99da808d224bdbb2047faf1def0d0f

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Akademický článek

Cellular and molecular bases of the initiation of fever.

Autor: Alexandre A Steiner, Andrei I Ivanov, Jordi Serrats, Hiroshi Hosokawa, Allison N Phayre, Jared R Robbins, Jennifer L Roberts, Shigeo Kobayashi, Kiyoshi Matsumura, Paul E Sawchenko, Andrej A Romanovsky

Publikováno v: PLoS Biology, Vol 4, Iss 9, p e284 (2006)

All phases of lipopolysaccharide (LPS)-induced fever are mediated by prostaglandin (PG) E2. It is known that the second febrile phase (which starts at approximately 1.5 h post-LPS) and subsequent phases are mediated by PGE2 that originated in endothe

Externí odkaz: https://doaj.org/article/9de30b9a4eb44907b2d4085fa8e27d8a

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Distribution of corticotropin-releasing factor (CRF) receptor binding in the mouse brain using a new, high-affinity radioligand, [125I]-PD-Sauvagine

Autor: Jean Rivier, Joan Vaughan, Marilyn H. Perrin, Laura A. Tan, Paul E. Sawchenko

Publikováno v: Journal of Comparative Neurology. 525:3840-3864

The corticotropin-releasing factor (CRF) family of peptides includes CRF and three urocortins, which signal through two distinct G-protein coupled receptors, CRF1 and CRF2 . Although the cellular distribution of CRF receptor expression has been well

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::83a15d9f34058f9515dbf58421640e08
https://doi.org/10.1002/cne.24307

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An anterograde neuroanatomical tracing method that shows the detailed morphology of neurons, their axons and terminals: Immunohistochemical localization of an axonally transported plant lectin, Phaseolus vulgaris-leucoagglutinin (PHA-L)

Autor: Charles R, Gerfen, Paul E, Sawchenko

Publikováno v: Brain Research. 1645:42-45

A new neuroanatomical method for tracing connections in the central nervous system based on the anterograde axonal transport of the kidney bean lectin, Phaseolus vulgaris-leucoagglutinin (PHA-L) is described. The method, for which a detailed protocol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358651f4d9abcfb6387c63bfb42bfd27
https://doi.org/10.1016/j.brainres.2015.12.040

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Corticotropin‐releasing factor receptor‐1 antagonism mitigates beta amyloid pathology and cognitive and synaptic deficits in a mouse model of Alzheimer's disease

Autor: Louise Monte, Setareh H. Moghadam, Eliezer Masliah, Paul E. Sawchenko, Shannon N. Campbell, Cheng Zhang, Kenner C. Rice, Ching-Chang Kuo, Robert A. Rissman

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 12, iss 5
Zhang, C; Kuo, CC; Moghadam, SH; Monte, L; Campbell, SN; Rice, KC; et al.(2016). Corticotropin-releasing factor receptor-1 antagonism mitigates beta amyloid pathology and cognitive and synaptic deficits in a mouse model of Alzheimer's disease. Alzheimer's and Dementia, 12(5), 527-537. doi: 10.1016/j.jalz.2015.09.007. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/738623k0

© 2016 Alzheimer's Association. Published by Elsevier Inc. All rights reserved. Introduction Stress and corticotropin-releasing factor (CRF) have been implicated as mechanistically involved in Alzheimer's disease (AD), but agents that impact CRF sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::903fb7aea599a34662fc0254716cb9e4
https://doi.org/10.1016/j.jalz.2015.09.007

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Evidence for involvement of a limbic paraventricular hypothalamic inhibitory network in hypothalamic-pituitary-adrenal axis adaptations to repeated stress

Autor: Jason J. Radley, Paul E. Sawchenko

Publikováno v: Journal of Comparative Neurology. 523:2769-2787

Emotional stressors activate a stereotyped set of limbic forebrain cell groups implicated in constraining stress-induced hypothalamic-pituitary-adrenal (HPA) axis activation by inhibiting hypophysiotropic neurons in the paraventricular hypothalamic n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0248fdc2cc50ce45c9e0bc7ca7279e67
https://doi.org/10.1002/cne.23815

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Characterization of a Pachymedusa dacnicolor–Sauvagine Analog as a New High-Affinity Radioligand for Corticotropin-Releasing Factor Receptor Studies

Autor: Kathy A. Lewis, Jean Rivier, Joan Vaughan, Judit Erchegyi, Cynthia J. Donaldson, Marilyn H. Perrin, Laura A. Tan, Paul E. Sawchenko, Charleen Miller

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 353:307-317

The corticotropin-releasing factor (CRF) peptide family comprises the mammalian peptides CRF and the urocortins as well as frog skin sauvagine and fish urophyseal urotensin. Advances in understanding the roles of the CRF ligand family and associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::675469e34282a16b3775f55611187b1e
https://doi.org/10.1124/jpet.114.222307

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Distribution of corticotropin-releasing factor (CRF) receptor binding in the mouse brain using a new, high-affinity radioligand, [

Autor: Laura A, Tan, Joan M, Vaughan, Marilyn H, Perrin, Jean E, Rivier, Paul E, Sawchenko

Publikováno v: The Journal of comparative neurology. 525(18)

The corticotropin-releasing factor (CRF) family of peptides includes CRF and three urocortins, which signal through two distinct G-protein coupled receptors, CRF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::35eee18eeb78a77d41d9338aa550ee73
https://pubmed.ncbi.nlm.nih.gov/28842924

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VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation

Publikováno v: Nature neuroscience
Nature neuroscience, vol 17, iss 12

SUMMARY Dopaminergic neurons in the ventral tegmental area (VTA) are well known for their role in mediating the positive reinforcing effects of drugs of abuse. Here, we identify in rodents and humans a population of VTA dopamine neurons co-expressing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::648ada6bd7b200232da4f1ecd6e0eb8f
https://doi.org/10.1038/nn.3872

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