Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Paul Digard"'
Autor:
Wenfang S Tan, Enguang Rong, Inga Dry, Simon G Lillico, Andy Law, Paul Digard, Bruce Whitelaw, Robert G Dalziel
Publikováno v:
PLoS Pathogens, Vol 19, Iss 12, p e1011822 (2023)
The advances in gene editing bring unprecedented opportunities in high throughput functional genomics to animal research. Here we describe a genome wide CRISPR knockout library, btCRISPRko.v1, targeting all protein coding genes in the cattle genome.
Externí odkaz:
https://doaj.org/article/9b23bb4e4bcd4b9fa5e52e039bc09552
Autor:
Jing Yang, Chunge Zhang, Yue Yuan, Ju Sun, Lu Lu, Honglei Sun, Heting Sun, Dong Chu, Siyuan Qin, Jianjun Chen, Chengbo Zhang, Xiyan Hao, Weifeng Shi, Wenjun Liu, George F. Gao, Paul Digard, Samantha Lycett, Yuhai Bi
Publikováno v:
Emerging Infectious Diseases, Vol 29, Iss 6, Pp 1244-1249 (2023)
Two novel reassortant highly pathogenic avian influenza viruses (H5N1) clade 2.3.4.4b.2 were identified in dead migratory birds in China in November 2021. The viruses probably evolved among wild birds through different flyways connecting Europe and A
Externí odkaz:
https://doaj.org/article/a6e279857e884b3f99a7776ddde82742
Autor:
Hannah Goldswain, Xiaofeng Dong, Rebekah Penrice-Randal, Muhannad Alruwaili, Ghada T. Shawli, Tessa Prince, Maia Kavanagh Williamson, Jayna Raghwani, Nadine Randle, Benjamin Jones, I’ah Donovan-Banfield, Francisco J. Salguero, Julia A. Tree, Yper Hall, Catherine Hartley, Maximilian Erdmann, James Bazire, Tuksin Jearanaiwitayakul, Malcolm G. Semple, Peter J. M. Openshaw, J. Kenneth Baillie, ISARIC4C Investigators, Stevan R. Emmett, Paul Digard, David A. Matthews, Lance Turtle, Alistair C. Darby, Andrew D. Davidson, Miles W. Carroll, Julian A. Hiscox
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-23 (2023)
Abstract Background The mutational landscape of SARS-CoV-2 varies at the dominant viral genome sequence and minor genomic variant population. During the COVID-19 pandemic, an early substitution in the genome was the D614G change in the spike protein,
Externí odkaz:
https://doaj.org/article/b3d75d58548e46f4b79481a60a9b08d2
Autor:
Wenfang Spring Tan, Enguang Rong, Inga Dry, Simon Lillico, Andy Law, Paul Digard, Bruce Whitelaw, Robert G. Dalziel
Publikováno v:
Viruses, Vol 16, Iss 2, p 297 (2024)
To identify host factors that affect Bovine Herpes Virus Type 1 (BoHV-1) infection we previously applied a genome wide CRISPR knockout screen targeting all bovine protein coding genes. By doing so we compiled a list of both pro-viral and anti-viral p
Externí odkaz:
https://doaj.org/article/92554c5a6aef4e69a1b87f7073f7b160
Autor:
Colin P Sharp, Beth H Thompson, Tessa J Nash, Ola Diebold, Rute M Pinto, Luke Thorley, Yao-Tang Lin, Samantha Sives, Helen Wise, Sara Clohisey Hendry, Finn Grey, Lonneke Vervelde, Peter Simmonds, Paul Digard, Eleanor R Gaunt
Publikováno v:
PLoS Pathogens, Vol 19, Iss 5, p e1011357 (2023)
Synonymous recoding of RNA virus genomes is a promising approach for generating attenuated viruses to use as vaccines. Problematically, recoding typically hinders virus growth, but this may be rectified using CpG dinucleotide enrichment. CpGs are rec
Externí odkaz:
https://doaj.org/article/6c1353e296d148f5a88dfc35be436326
Autor:
Katrina M. Morris, Anamika Mishra, Ashwin A. Raut, Eleanor R. Gaunt, Dominika Borowska, Richard I. Kuo, Bo Wang, Periyasamy Vijayakumar, Santhalembi Chingtham, Rupam Dutta, Kenneth Baillie, Paul Digard, Lonneke Vervelde, David W. Burt, Jacqueline Smith
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/5370ab1a7b1f4d15b26fff508d09c4ec
Autor:
Katrina M. Morris, Anamika Mishra, Ashwin A. Raut, Eleanor R. Gaunt, Dominika Borowska, Richard I. Kuo, Bo Wang, Periyasamy Vijayakumar, Santhalembi Chingtham, Rupam Dutta, Kenneth Baillie, Paul Digard, Lonneke Vervelde, David W. Burt, Jacqueline Smith
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
IntroductionHighly pathogenic avian influenza (HPAI) viruses, such as H5N1, continue to pose a serious threat to animal agriculture, wildlife and to public health. Controlling and mitigating this disease in domestic birds requires a better understand
Externí odkaz:
https://doaj.org/article/0c771ab9c6154743906b0e5a08ab25cb
Autor:
Aidan D. Roche, Alistair C. McConnell, Karen Donaldson, Angus Lawson, Spring Tan, Kate Toft, Gillian Cairns, Alexandre Colle, Andrew A. Coleman, Ken Stewart, Paul Digard, John Norrie, Adam A. Stokes
Publikováno v:
Frontiers in Medical Technology, Vol 4 (2022)
Widespread issues in respirator availability and fit have been rendered acutely apparent by the COVID-19 pandemic. This study sought to determine whether personalized 3D printed respirators provide adequate filtration and function for healthcare work
Externí odkaz:
https://doaj.org/article/be9ddfbcecea426aa1cfa1188e2f7c52
Autor:
Ignazio Maria Viola, Brian Peterson, Gabriele Pisetta, Geethanjali Pavar, Hibbah Akhtar, Filippo Menoloascina, Enzo Mangano, Katherine E. Dunn, Roman Gabl, Alex Nila, Emanuela Molinari, Cathal Cummins, Gerard Thompson, Tsz-Yan Milly Lo, Fiona C. Denison, Paul Digard, Omair Malik, Mark J. G. Dunn, Catherine M. McDougall, Felicity V. Mehendale
Publikováno v:
IEEE Open Journal of Engineering in Medicine and Biology, Vol 2, Pp 26-35 (2021)
The SARS-CoV-2 virus is primarily transmitted through virus-laden fluid particles ejected from the mouth of infected people. Face covers can mitigate the risk of virus transmission but their outward effectiveness is not fully ascertained. Objective:
Externí odkaz:
https://doaj.org/article/2efcee0d775a4c3aba1b7dfa01747d71
Autor:
Karen J. Bryson, Samantha Sives, Hui-Min Lee, Dominika Borowska, Jacqueline Smith, Paul Digard, Lonneke Vervelde
Publikováno v:
Viruses, Vol 15, Iss 3, p 591 (2023)
Evidence suggests that susceptibility to avian influenza A virus in chickens is influenced by host genetics, but the mechanisms are poorly understood. A previous study demonstrated that inbred line 0 chickens are more resistant to low-pathogenicity a
Externí odkaz:
https://doaj.org/article/1b40182db5cd4c22a8f7c36a312d2b3f