Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Paul D. Wightman"'
Autor:
Robert Schwenk, Margot DeBot, Michael Porter, Jennifer Nikki, Lisa Rein, Roberta Spaccapelo, Andrea Crisanti, Paul D Wightman, Christian F Ockenhouse, Sheetij Dutta
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111020 (2014)
The availability of a highly purified and well characterized circumsporozoite protein (CSP) is essential to improve upon the partial success of recombinant CSP-based malaria vaccine candidates. Soluble, near full-length, Plasmodium falciparum CSP vac
Externí odkaz:
https://doaj.org/article/a869513f630b47ba8f3cff2f52d3523e
Publikováno v:
Vaccine. 29:5434-5442
The human Toll-like receptors (TLRs) are a family of receptors, which sense the presence of various structural elements of pathogens and damaged or effete components in the host. As they do so, they activate two critical arms of host defense, the rap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1f39f3f8c69c43c2f376c61b044c28
https://doi.org/10.1016/j.vaccine.2011.05.061
https://doi.org/10.1016/j.vaccine.2011.05.061
Publikováno v:
Biochemical Journal. 409:275-287
The mammalian TLRs (Toll-like receptors) mediate the rapid initial immune response to pathogens through recognition of pathogen-associated molecular patterns. The pathogen pattern to which TLR8 responds is ssRNA (single-stranded RNA) commonly associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4741730e178fba07b8b0e9074b4581e
https://doi.org/10.1042/bj20070519
https://doi.org/10.1042/bj20070519
Autor:
Roberta Spaccapelo, Lisa Rein, Michael D. Porter, Christian F. Ockenhouse, Sheetij Dutta, Robert Schwenk, Andrea Crisanti, Jennifer Nikki, Paul D. Wightman, Margot DeBot
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111020 (2014)
PLoS ONE
PLoS ONE
The availability of a highly purified and well characterized circumsporozoite protein (CSP) is essential to improve upon the partial success of recombinant CSP-based malaria vaccine candidates. Soluble, near full-length, Plasmodium falciparum CSP vac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad0831738bc1d5f0f4827ed2c2a3b7b7
http://hdl.handle.net/11391/1318706
http://hdl.handle.net/11391/1318706
Autor:
John J. L. Battiste, John P. Vasilakos, Xiaohong Qiu, Sefik S. Alkan, Paul D. Wightman, Keith B. Gorden
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 177(11)
Among the 11 human TLRs, a subfamily TLR7, TLR8, and TLR9 display similarities in structure and endosomal localization. Natural agonists consisting of nucleic acids, such as ssRNA or DNA with CpG motifs, activate the innate immune cells through these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ab82edac6d2a54f1305a9fbc011deb4
https://pubmed.ncbi.nlm.nih.gov/17114492
https://pubmed.ncbi.nlm.nih.gov/17114492
Publikováno v:
The Journal of biological chemistry. 281(49)
Toll-like receptors (TLRs) TLR1, TLR2, TLR4, and TLR6 are evolutionarily conserved, highly homologous, and localized to plasma membranes of host cells and recognize pathogen-associated molecular patterns (PAMPs) derived from bacterial membranes. Thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::567912be88628465b7198a747c6f0502
https://pubmed.ncbi.nlm.nih.gov/17040905
https://pubmed.ncbi.nlm.nih.gov/17040905
Autor:
Jerzy Fraczek, Paul D. Wightman, Shizuo Akira, Hui Xiao, Jinzhong Qin, Bing Su, Jean-Laurent Casanova, Jianhong Yao, Grace Cui, Tae Whan Kim, Shintaro Sato, Xiaoxia Li, Anne Puel
Publikováno v:
The Journal of biological chemistry. 281(30)
TLR8-mediated NF-kappaB and IRF7 activation are abolished in human IRAK-deficient 293 cells and IRAK4-deficient fibroblast cells. Both wild-type and kinase-inactive mutants of IRAK and IRAK4, respectively, restored TLR8-mediated NF-kappaB and IRF7 ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5fc1dbeea9e446b31c7b1d2d42c1dfd
https://pubmed.ncbi.nlm.nih.gov/16737960
https://pubmed.ncbi.nlm.nih.gov/16737960
Publikováno v:
The FASEB Journal. 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e25c536ebd2fc8471debb00132469a33
https://doi.org/10.1096/fasebj.20.4.a112-a
https://doi.org/10.1096/fasebj.20.4.a112-a
Publikováno v:
Biochemical Journal; 2008, Vol. 409 Issue 1, p275-287, 13p
Publikováno v:
Biochemical Pharmacology. 28:2471-2478
Mouse peritoneal macrophages turn over their membrane components rapidly. The biosynthetic pathway for phosphatidylcholine synthesis from choline can be inhibited in a non-toxic manner by a series of diphenylsulfones. The parent compound of this seri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ab31fe2bc5b22c7232b18e1c33457b7
https://doi.org/10.1016/0006-2952(79)90010-8
https://doi.org/10.1016/0006-2952(79)90010-8