Výsledky vyhledávání - "Paul D. Madge"

Akademický článek

Neutralizing the pathological effects of extracellular histones with small polyanions

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)

Histones, proteins that bind DNA, are toxic for pathogens outside cells but can also cause multi-organ damage as seen in sepsis. Here the authors develop small negatively charged molecules that can be used as histone antidotes, and show that they imp

Externí odkaz: https://doaj.org/article/47652de3a653433fb4ea511fb90437ea

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Neutralizing the pathological effects of extracellular histones with small polyanions

Publikováno v: Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)

Extracellular histones in neutrophil extracellular traps (NETs) or in chromatin from injured tissues are highly pathological, particularly when liberated by DNases. We report the development of small polyanions (SPAs) (~0.9–1.4 kDa) that interact e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da1009f901f83eaeea74a8d3ef9f071
https://pubmed.ncbi.nlm.nih.gov/33328478

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Access to 3-O-Functionalized N-Acetylneuraminic Acid Scaffolds

Autor: Robin J. Thomson, Mauro Pascolutti, Mark von Itzstein, Paul D. Madge

Publikováno v: The Journal of Organic Chemistry. 80:7746-7751

Direct access to 3-O-functionalized 2-α-N-acetylneuraminides and their corresponding 2,3-dehydro-2-deoxy-N-acetylneuraminic acid derivatives is described. Initially, a stereoselective ring-opening of the key intermediate N-acetylneuraminic acid (Neu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc9c65774cb0332f270fc35a64fc7f3e
https://doi.org/10.1021/acs.joc.5b00992

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Relative Roles of GM1 Ganglioside, N -Acylneuraminic Acids, and α2β1 Integrin in Mediating Rotavirus Infection

Autor: Helen Blanchard, Paul D. Madge, Jaigeeth Deveryshetty, Barbara S. Coulson, Mark von Itzstein, Fiona E. Fleming, Thomas Haselhorst, Gavan Holloway, Xing Yu, Raphael Böhm, Vi T. Dang

Publikováno v: Journal of Virology. 88:4558-4571

N -acetyl- and N -glycolylneuraminic acids (Sia) and α2β1 integrin are frequently used by rotaviruses as cellular receptors through recognition by virion spike protein VP4. The VP4 subunit VP8*, derived from Wa rotavirus, binds the internal N -acet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20b523c151cf799f8c683e0249cfef68
https://doi.org/10.1128/jvi.03431-13

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Microwave-assisted synthesis of N-glycolylneuraminic acid derivatives

Autor: Pradeep Chopra, I. Darren Grice, Robin J. Thomson, Paul D. Madge, Mark von Itzstein

Publikováno v: Tetrahedron Letters. 54:5558-5561

A rapid, efficient and scalable synthesis of biologically-relevant N-glycolylneuraminic acid derivatives from the natural N-acetyl (Neu5Ac) precursors has been developed. Microwave irradiation provides accelerated de-N-acetylation compared to more tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f46c0dc65488c37a6ab237a3088f2246
https://doi.org/10.1016/j.tetlet.2013.07.107

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Structural characterisation of high affinity Siglec-2 (CD22) ligands in complex with whole Burkitt’s lymphoma (BL) Daudi cells by NMR spectroscopy

Autor: Moein Amin, Mauro Pascolutti, Andrea Maggioni, Paul D. Madge, Mario Waespy, Bernadette Bellette, Mark von Itzstein, Sørge Kelm, Thomas Haselhorst, Robin J. Thomson

Publikováno v: Scientific Reports

Siglec-2 undergoes constitutive endocytosis and is a drug target for autoimmune diseases and B cell-derived malignancies, including hairy cell leukaemia, marginal zone lymphoma, chronic lymphocytic leukaemia and non-Hodgkin’s lymphoma (NHL). An alt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d1b747c98a71ea7904c93baf1b2b3a
https://doi.org/10.1038/srep36012

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Synthesis and biological evaluation of galactofuranosyl alkyl thioglycosides as inhibitors of mycobacteria

Autor: David J. Owen, Christopher Davis, Robin J. Thomson, Mark von Itzstein, Regan David Hartnell, Andrew Chong, Paul D. Madge, Ross L. Coppel

Publikováno v: Carbohydrate Research. 342:1773-1780

As part of our research interest directed toward the development of antimycobacterial agents, we have investigated compounds based on galactofuranose (Galf), an essential cell wall component of mycobacteria. The objective of this study was to explore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c596b29c88c6105f579c4b5f7c61adfa
https://doi.org/10.1016/j.carres.2007.04.027

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Synthesis and evaluation of galactofuranosyl N,N-dialkyl sulfenamides and sulfonamides as antimycobacterial agents

Autor: Robin J. Thomson, David J. Owen, Mark von Itzstein, Ross L. Coppel, Andrew Chong, Regan David Hartnell, Paul D. Madge, Christopher Davis

Publikováno v: Monash University

The recent emergence of clinically oppressive superbugs, some with resistance to nearly all frontline drug therapies, has challenged our ability to combat such infectious organisms as Mycobacterium tuberculosis, the causative agent of tuberculosis (T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d066a94fc52274ea204ad0002253839
https://doi.org/10.1016/j.bmcl.2007.01.068

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