Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Paul D. Lira"'
Autor:
Chunli Huang, Paul D. Lira, Love Victoria Alexandria, Oliphant Theodore Lawrence, Leslie L. Sharp, Sharon A. Sokolowski, Simon Bergqvist, Amy C. Shen, Rohner Allison Karlyn, Timothy Scott Fisher, Sangita M. Baxi, Regis Doyonnas, Cris Kamperschroer
Publikováno v:
Cancer Immunology, Immunotherapy. 61:1721-1733
4-1BB (CD137, TNFRSF9) is a costimulatory receptor expressed on several subsets of activated immune cells. Numerous studies of mouse and human T cells indicate that 4-1BB promotes cellular proliferation, survival, and cytokine production. 4-1BB agoni
Autor:
Donald M. Engelman, Paul D. Lira, Erin E. Matthews, Damien Thévenin, Lisa Gotow, Lawrence A. Reiter, William H. Brissette, Julia M. Rogers
Publikováno v:
The FASEB Journal. 25:2234-2244
We report how rotational variations in transmembrane (TM) helix interactions participate in the activity states of the thrombopoietin receptor (TpoR), a type 1 cytokine receptor that controls the production of blood platelets. We also explore the mec
Autor:
Paul A. Rejto, James S. Hardwick, Jadwiga Bienkowska, Kai Wang, Thomas O’Brien, Mark Ozeck, Donghui Huang, Keith A. Ching, Geoffrey Chan, Jingjin Gao, Paul D. Lira
Publikováno v:
Cancer Research. 78:LB-215
Background: The Hedgehog (Hh) signaling pathway is key to development, differentiation, and stem cell maintenance. In cancer, dysregulation of Hh signaling is associated with solid tumors and hematological malignancies. Hh signaling in AML and MDS is
Autor:
David G. Perregaux, Timothy Scott Fisher, William H. Brissette, Paul D. Lira, Jeffrey L. Stock, Baiyong Li, Terence R.S. Ozolinš
Publikováno v:
Biochemical and Biophysical Research Communications. 388:683-688
HIF (hypoxia-inducible factor) hydroxylases have been implicated in EPO (erythropoietin) production and erythropoiesis. Here we examined the role of each of the three EGLN family members and the HIF asparaginyl hydroxylase FIH (factor inhibiting HIF)
Autor:
James H. Roache, Eric B. McElroy, Timothy Joseph Paradis, Aikomari Guzman-Martinez, Sara A. Burrell, Robert S. Foti, Matthew Frank Brown, Greg D. Lundquist, Kevin B. Bahnck, James P. Driscoll, Andrei Shavnya, Laurie Tylaska, Ronald P. Gladue, Michael B. Fisher, Poss Christopher Stanley, Molly A. McGlynn, William H. Brissette, Yi Lu, Brett M. Lillie, Laura Cook Blumberg, Flavia Fedeles, Matthew Merrill Hayward, Richard M. Shepard, Kristen A. Trevena, Paul D. Lira
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3109-3112
The synthesis, biological activity, and pharmacokinetic profile of CCR1 antagonists are described.
Autor:
Matthew Frank Brown, William H. Brissette, Amy P DiRico, Eric B. McElroy, Ronald P. Gladue, Timothy Joseph Paradis, Laurie Tylaska, Maryrose J. Conklyn, Deye Zheng, Erin N Mairs, John Charles Kath, Poss Christopher Stanley, Molly A. McGlynn, Dorff Peter H, William H. Martin, Brett M. Lillie, Ingrid A. Stock, Paul D. Lira
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:2169-2173
The present manuscript details structure-activity relationship studies of lead structure 1, which led to the discovery of CCR1 antagonists >100-fold more potent than 1.
Autor:
Mary M. Payette, Laurent P. Audoly, Joan R. Wicks, William H. Brissette, Sandra P. McCurdy, Christopher A. Gabel, Carol Donovan, Nina Petrushova, Jeffrey M. Labasi, Paul D. Lira
Publikováno v:
The Journal of Immunology. 168:6436-6445
When challenged with extracellular ATP, leukocytes respond and activate processes attributed to the P2X7 receptor (P2X7R), an unusual ligand-gated ion channel. To prove P2X7R involvement, blood samples from P2X7R-deficient mice were characterized. Mo
Autor:
Gianni Medoro, Ana Paula Galvão Da Silva, Farideh Z. Bischoff, Paul D. Lira, Nicolò Manaresi, Jennifer Chow
Publikováno v:
Journal of Clinical Oncology. 35:e23089-e23089
e23089 Background: Tumor infiltrating lymphocytes (TILs) are biomarkers that play a critical role in cancer diseases, including differential diagnosis, determination of prognosis, prediction of response to treatment, and evaluation of disease progres
Autor:
Lynn M. Hames, Ranjeny Thomas, Robin T. Nelson, William H. Brissette, Lisa S. Hayes, Ronald P. Gladue, Paul D. Lira, Ann C. Cunningham, Shaun R. McColl, James G. Boyd, Timothy Joseph Paradis, Kuldeep S. Neote
Publikováno v:
Genomics. 73:28-37
We describe the genomic organization of a recently identified CC chemokine, MIP3 alpha /CCL20 (HGMW-approved symbol SCYA20). The MIP-3 alpha /CCL20 gene was cloned and sequenced, revealing a four exon, three intron structure, and was localized by FIS
Autor:
Lilli Ann Wolf-Gouveia, Paul D. Lira, Eric B. McElroy, Lisa Marie Thomasco, Matthew Frank Brown, Christopher S. Jones, Jonathan L. Doty, Lawrence A. Reiter, Sandra P. McCurdy, Anthony Marfat, Sharon L. Ripp, Mark J. Mitton-Fry, William H. Brissette, Andrei Shavnya, Linde Robert Gerald, Thomas M. Harris, Kristen A. Trevena, Qifang Li, Laura Cook Blumberg, Amy S. Antipas, James P. Driscoll, Michael John Munchhof, Jeffrey M. Casavant
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1428-1430
Recently, we disclosed a series of potent pyrimidine benzamide-based thrombopoietin receptor agonists. Unfortunately, the structural features required for the desired activity conferred physicochemical properties that were not favorable for the devel