Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Paul D. Kennedy"'
Autor:
Gisela Brändén, Paul D Kennedy, Aaron A Koch, Neil P. J. Price, Trina M. Hartman, Margareta Ek, Michael A. Jackson
Publikováno v:
ACS Chemical Biology. 16:116-124
Branched-chain fatty acids (BCFA) are encountered in Gram-positive bacteria, but less so in other organisms. The bacterial BCFA in membranes are typically saturated, with both odd- and even-numbered carbon chain lengths, and with methyl branches at e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80a759ccc4d01b57c417cc888a6b7ea9
https://doi.org/10.1021/acschembio.0c00799
https://doi.org/10.1021/acschembio.0c00799
Autor:
Peng Liao, Weimin Wang, Weichao Wang, Ilona Kryczek, Xiong Li, Yingjie Bian, Amanda Sell, Shuang Wei, Sara Grove, Jeffrey K. Johnson, Paul D. Kennedy, Miguel Gijón, Yatrik M. Shah, Weiping Zou
Publikováno v:
Cancer Cell
Tumor cell intrinsic ferroptosis initiating mechanisms are unknown. Here, we discover T cell-derived interferon (IFN)γ in combination with arachidonic acid (AA) induces immunogenic tumor ferroptosis, serving as a mode of action for CD8(+) T cell (CT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2fb2f9dd1a2d7564a809d209975b230
https://pubmed.ncbi.nlm.nih.gov/35469799
https://pubmed.ncbi.nlm.nih.gov/35469799
Autor:
Hongjuan Zhang, Timothy A. Chan, Michael D. Green, Linda Vatan, Theodore S. Lawrence, Miguel Gijón, Weiping Zou, Gaopeng Li, Shuang Wei, Arul M. Chinnaiyan, Everett Stone, Marcin Cieslik, Wojciech Szeliga, Jiajia Zhou, Jae Eun Choi, Wei Gu, Jeffrey K. Johnson, Rebecca Liu, Yuri Tanno, Ilona Kryczek, Amanda Sell, Xueting Lang, Candice Lamb, Houjun Xia, Peng Liao, George Georgiou, Paul D. Kennedy, Weimin Wang, Jing Li, Wei Li
Publikováno v:
Nature. 569:270-274
Cancer immunotherapy restores or enhances the effector function of CD8+ T cells in the tumour microenvironment1,2. CD8+ T cells activated by cancer immunotherapy clear tumours mainly by inducing cell death through perforin-granzyme and Fas-Fas ligand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25a27ebcb7ad67fb878553a77c0ae191
https://doi.org/10.1038/s41586-019-1170-y
https://doi.org/10.1038/s41586-019-1170-y
Autor:
Neil P J, Price, Michael A, Jackson, Trina M, Hartman, Gisela, Brändén, Margareta, Ek, Aaron A, Koch, Paul D, Kennedy
Publikováno v:
ACS chemical biology. 16(1)
Branched-chain fatty acids (BCFA) are encountered in Gram-positive bacteria, but less so in other organisms. The bacterial BCFA in membranes are typically saturated, with both odd- and even-numbered carbon chain lengths, and with methyl branches at e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5ecb25bf3d78ad427503e81bfb73d7cb
https://pubmed.ncbi.nlm.nih.gov/33411499
https://pubmed.ncbi.nlm.nih.gov/33411499
Autor:
Weimin, Wang, Michael, Green, Jae Eun, Choi, Miguel, Gijón, Paul D, Kennedy, Jeffrey K, Johnson, Peng, Liao, Xueting, Lang, Ilona, Kryczek, Amanda, Sell, Houjun, Xia, Jiajia, Zhou, Gaopeng, Li, Jing, Li, Wei, Li, Shuang, Wei, Linda, Vatan, Hongjuan, Zhang, Wojciech, Szeliga, Wei, Gu, Rebecca, Liu, Theodore S, Lawrence, Candice, Lamb, Yuri, Tanno, Marcin, Cieslik, Everett, Stone, George, Georgiou, Timothy A, Chan, Arul, Chinnaiyan, Weiping, Zou
Publikováno v:
Nature. 569(7755)
Ferroptosis is a form of regulated cell death involving lethal peroxidation of phospholipids (Hirschhorn and Stockwell, 2018). Recent results reveal that ferroptosis mediates the tumor suppressive activity of interferon gamma secreted by CD8(+) T cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bda4534ba2c2feacee31ba228787eb30
https://pubmed.ncbi.nlm.nih.gov/31269423
https://pubmed.ncbi.nlm.nih.gov/31269423
Autor:
William E. Fantegrossi, Jeffery H. Moran, Gregory W. Endres, Cindy L. Moran, Laura P. James, Nancy J. Rusch, Paul D. Kennedy, Kathryn A. Seely, Amy L. Patton, Laura D. Knight, Sharon Pulla, Jeanna M. Marraffa
Publikováno v:
Analytical Chemistry. 86:1760-1766
Opioid abuse involving emerging opioid compounds is a growing public health problem, which was highlighted recently by cases of human morbidity and mortality linked to acetyl fentanyl abuse. Unfortunately, the lack of information available on the tox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c4f82bf83000d8a332ecd338a9a66d2
https://doi.org/10.1021/ac4036197
https://doi.org/10.1021/ac4036197
Autor:
Matthew Trass, Gregory W. Endres, Amy L. Patton, Paul J. Dobrowolski, Krishna C. Chimalakonda, Art Miranda, Laura P. James, William E. Fantegrossi, Keith R. McCain, Kathryn A. Seely, Johnny P Tran, Jeffery H. Moran, Paul D. Kennedy, Anna Radominska-Pandya
Publikováno v:
Analytical Chemistry. 85:9390-9399
Designer synthetic cannabinoids like JWH-018 and AM2201 have unique clinical toxicity. Cytochrome-P450-mediated metabolism of each leads to the generation of pharmacologically active (ω)- and (ω-1)-monohydroxyl metabolites that retain high affinity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e067f7db56365b89789331669298dfd4
https://doi.org/10.1021/ac4024704
https://doi.org/10.1021/ac4024704
Autor:
Cindy L. Moran, Andrei M. Kornilov, Anna Radominska-Pandya, Laura P. James, Vi-Huyen Le, William D. Wessinger, James B. Kramer, Larry D. Bratton, Paul D. Kennedy, Jeffery H. Moran, Paul J. Dobrowolski, Amy L. Smedley, Felisia D. Lackey, Paul L. Prather, Gregory W. Endres, Krishna C. Chimalakonda, Suzanne N. Owen, William E. Fantegrossi, Fred Lawrence Ciske
Publikováno v:
Analytical Chemistry. 83:4228-4236
'K2/SPICE' products are commonly laced with aminoalkylindole synthetic cannabinoids (i.e., JWH-018 and JWH-073) and are touted as ‘legal’ marijuana substitutes. Here we validate a liquid chromatography tandem mass spectrometry (LC-MS/MS) methsod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f7c1f2e89afa46a2dd955c8dfaf1df3
https://doi.org/10.1021/ac2005636
https://doi.org/10.1021/ac2005636
Autor:
Paul J. Dobrowolski, Krishna C. Chimalakonda, Jeff Lapoint, Jeffery H. Moran, Cindy L. Moran, Lewis S. Nelson, Anna Radominska-Pandya, Laura P. James, Gregory W. Endres, Robert S. Hoffman, Paul D. Kennedy, Kim E. Fifer, Adam Uzieblo
Publikováno v:
Analytical chemistry. 83(16)
The aminoalkylindole agonists JWH-018 and JWH-073 are contained in "K2/SPICE" products sold as "legal marijuana". Previous human metabolic studies have identified (ω)-hydroxyl and (ω)-carboxyl metabolites as biomarkers that are indicative of produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85fd19d82f9b84ffb99b6bc6c8646579
https://pubmed.ncbi.nlm.nih.gov/21740038
https://pubmed.ncbi.nlm.nih.gov/21740038
