Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Paul D. Flynn"'
Autor:
Charles ffrench-Constant, David G. MacManus, Jonathan Stutters, Owen R Pearson, DT Chard, Baris Kanber, Edward Needham, Zoya Georgieva, Joanne L. Jones, David Rog, Alasdair Coles, Rebecca S. Samson, Claudia A. M. Wheeler-Kingshott, J William L Brown, Ferran Prados, Peter Connick, Andrew W. Michell, Siddharthan Chandran, James Overell, Daniel R. Altmann, Paul D Flynn, Robin J.M. Franklin, Nick G Cunniffe, Carla Moran
Publikováno v:
Brown, J W L, Cunniffe, N G, Prados, F, Kanber, B, Jones, J L, Needham, E, Georgieva, Z, Rog, D, Pearson, O R, Overell, J, Macmanus, D, Samson, R S, Stutters, J, Ffrench-constant, C, Gandini Wheeler-kingshott, C A M, Moran, C, Flynn, P D, Michell, A W, Franklin, R J M, Chandran, S, Altmann, D R, Chard, D T, Connick, P & Coles, A J 2021, ' Safety and efficacy of bexarotene in patients with relapsing-remitting multiple sclerosis (CCMR One): a randomised, double-blind, placebo-controlled, parallel-group, phase 2a study ', The Lancet Neurology, vol. 20, no. 9, pp. 709-720 . https://doi.org/10.1016/S1474-4422(21)00179-4
Summary Background Progressive disability in multiple sclerosis occurs because CNS axons degenerate as a late consequence of demyelination. In animals, retinoic acid receptor RXR-gamma agonists promote remyelination. We aimed to assess the safety and
Autor:
Vassilios S Vassiliou, Paul D Flynn, Claire E Raphael, Simon Newsome, Tina Khan, Aamir Ali, Brian Halliday, Annina Studer Bruengger, Tamir Malley, Pranev Sharma, Subothini Selvendran, Nikhil Aggarwal, Anita Sri, Helen Berry, Jackie Donovan, Willis Lam, Dominique Auger, Stuart A Cook, Dudley J Pennell, Sanjay K Prasad
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181077 (2017)
BackgroundAortic stenosis is the most common age-related valvular pathology. Patients with aortic stenosis and myocardial fibrosis have worse outcome but the underlying mechanism is unclear. Lipoprotein(a) is associated with adverse cardiovascular ri
Externí odkaz:
https://doaj.org/article/abbb406520b44f0aa5596c697f958ca4
Autor:
Kieran G. Meade, Ronan Whiston, Paul Cormican, Patrick Lonergan, Cliona O' Farrelly, Emma K. Finlay, Andrew Cromie, Peter J. Hansen, A. Lyons, Sean Fair, Paul D Flynn, Matthew S. McCabe
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Bovine fertility remains a critical issue underpinning the sustainability of the agricultural sector. Phenotypic records collected on >7,000 bulls used in artificial insemination (AI) were used to identify 160 reliable and divergently fertile bulls f
Autor:
Vassilios S. Vassiliou, Pranev Sharma, Helen L. Berry, Willis Lam, Brian P Halliday, Simon Newsome, Paul D Flynn, Annina Studer Bruengger, Dudley J. Pennell, Tamir Malley, Tina Z. Khan, Aamir Ali, Claire E. Raphael, Sanjay K Prasad, Dominique Auger, Nikhil Aggarwal, Stuart A. Cook, Jackie Donovan, Subothini Selvendran, Anita Sri
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 7, p e0181077 (2017)
PLoS ONE, Vol 12, Iss 7, p e0181077 (2017)
BackgroundAortic stenosis is the most common age-related valvular pathology. Patients with aortic stenosis and myocardial fibrosis have worse outcome but the underlying mechanism is unclear. Lipoprotein(a) is associated with adverse cardiovascular ri
Autor:
Vassilios S. Vassiliou, Paul D Flynn
Publikováno v:
The Lancet. 380:1718-1720
Autor:
Richard Ceska, Naveed Sattar, Elena Bilianou, Shun Ishibashi, Tamio Teramoto, Vincent Maher, Paul Valensi, Luis Masana, Kausik K. Ray, Paul D. Flynn, Henry N. Ginsberg, John J.P. Kastelein, Xavier Garcia-Moll, Selim Jambart, Ibrahim Salti, D. John Betteridge, Carlo Maria Rotella, Raimund Erbel, Deepak Bhatnagar, Terje R. Pedersen, Peter P. Toth, Lale Tokgozoglu, Masato Odawara, Bruno Vergès, Marcello Arca, Rafael Carmena, Alberto Corsini, Janusz Gumprecht, M. John Chapman, Maurizio Averna, Pedro Marques da Silva
Publikováno v:
ATHEROSCLEROSIS SUPPLEMENTS
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Atherosclerosis Supplements
Repositori Institucional de la Universitat Rovira i Virgili
Consejo Superior de Investigaciones Científicas (CSIC)
Atherosclerosis. Supplements, 15(1), 1-15. Elsevier Ireland Ltd
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Atherosclerosis Supplements
Repositori Institucional de la Universitat Rovira i Virgili
Consejo Superior de Investigaciones Científicas (CSIC)
Atherosclerosis. Supplements, 15(1), 1-15. Elsevier Ireland Ltd
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
Reducing low-density lipoprotein cholesterol (LDL-C) levels using statins is associated with significant reductions in cardiovascular (CV) events in a wide range of patient populations. Although statins are generally considered to be safe, recent stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f36aa71ec21a591bd53dca64f073f4
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=9276
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=9276
Autor:
Matthew Hoare, Patrick Deegan, Paul D Flynn, William J.H. Griffiths, Andrew J. Butler, Ashley Shaw, Graeme K. Ambler, Rebecca Brais
Publikováno v:
JIMD Reports ISBN: 9783642334320
Ambler, G K, Hoare, M, Brais, R, Shaw, A, Butler, A, Flynn, P, Deegan, P & Griffiths, W J H 2012, Orthotopic Liver Transplantation in an Adult with Cholesterol Ester Storage Disease . in JIMD Reports-Case and Research Reports, 2012/5 . JMID Reports, vol. 8, Springer Berlin Heidelberg, pp. 41-46 . https://doi.org/10.1007/8904_2012_155
Ambler, G K, Hoare, M, Brais, R, Shaw, A, Butler, A, Flynn, P, Deegan, P & Griffiths, W J H 2012, Orthotopic Liver Transplantation in an Adult with Cholesterol Ester Storage Disease . in JIMD Reports-Case and Research Reports, 2012/5 . JMID Reports, vol. 8, Springer Berlin Heidelberg, pp. 41-46 . https://doi.org/10.1007/8904_2012_155
Cholesterol ester storage disease (CESD) is a rare autosomal recessive lipid storage disorder associated with mutations of the gene encoding lysosomal acid lipase, manifestations of which include chronic liver disease and early atherosclerosis. Altho
Publikováno v:
Cytokine. 12(4)
Transforming growth factor beta (TGFbeta) is thought to play an important role in the development and/or progression of a number of vascular disorders through its numerous effects on vascular smooth muscle cells (VSMCs). In this study we sought to id
Publikováno v:
Gene therapy. 5(2)
Replication-deficient adenoviral vectors have been widely used for gene transfer with the aim of delivering genes of interest to investigate their function and potentially to treat human disease. The ability to critically evaluate the biological role
Publikováno v:
Thrombosis research. 83(4)
The ability of unactivated and calcium ionophore activated platelets to support thrombin generation in defibrinated plasma was measured by a chromogenic substrate assay in the absence of clot formation. Platelet phospholipid-dependent thrombin genera