Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Paul D. Brewer"'
Autor:
Elena N. Atochina-Vasserman, Lisa C. Lindesmith, Carmen Mirabelli, Nathan A. Ona, Erin K. Reagan, Paul D. Brewer-Jensen, Xiomara Mercado-Lopez, Hamna Shahnawaz, Jaclynn A. Meshanni, Ishana Baboo, Michael L. Mallory, Mark R. Zweigart, Samantha R. May, Barbara L. Mui, Ying K. Tam, Christiane E. Wobus, Ralph S. Baric, Drew Weissman
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-11 (2024)
Abstract Nucleoside-modified mRNA-LNP vaccines have revolutionized vaccine development against infectious pathogens due to their ability to elicit potent humoral and cellular immune responses. In this article, we present the results of the first noro
Externí odkaz:
https://doaj.org/article/edc4158664a44a999625dbd69f0184a0
Autor:
Camilla A. Strother, Paul D. Brewer-Jensen, Sylvia Becker-Dreps, Omar Zepeda, Samantha May, Fredman Gonzalez, Yaoska Reyes, Benjamin D. McElvany, April M. Averill, Michael L. Mallory, Anna M. Montmayeur, Verónica P. Costantini, Jan Vinjé, Ralph S. Baric, Filemon Bucardo, Lisa C. Lindesmith, Sean A. Diehl
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Genogroup II (GII) noroviruses are a major cause of diarrheal disease burden in children in both high- and low-income countries. GII.17 noroviruses are composed of distinct genetic clusters (I, II, IIIa, and IIIb) and have shown potential for replaci
Externí odkaz:
https://doaj.org/article/070a86a385d44fda9d0010f529972c4c
Autor:
Lisa C. Lindesmith, Florencia A. T. Boshier, Paul D. Brewer-Jensen, Sunando Roy, Veronica Costantini, Michael L. Mallory, Mark Zweigart, Samantha R. May, Helen Conrad, Kathleen M. O’Reilly, Daniel Kelly, Cristina C. Celma, Stuart Beard, Rachel Williams, Helena J. Tutill, Sylvia Becker Dreps, Filemón Bucardo, David J. Allen, Jan Vinjé, Richard A. Goldstein, Judith Breuer, Ralph S. Baric
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT Understanding the complex interactions between virus and host that drive new strain evolution is key to predicting the emergence potential of variants and informing vaccine development. Under our hypothesis, future dominant human norovirus G
Externí odkaz:
https://doaj.org/article/c120f0502f0347849ac81326821d9337
Autor:
Ajinkya Pattekar, Lena S. Mayer, Chi Wai Lau, Chengyang Liu, Olesya Palko, Meenakshi Bewtra, HPAP Consortium, Lisa C. Lindesmith, Paul D. Brewer-Jensen, Ralph S. Baric, Michael R. Betts, Ali Naji, E. John Wherry, Vesselin T. Tomov
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1267-1289 (2021)
Background & Aims: Noroviruses (NoVs) are the leading cause of acute gastroenteritis worldwide and are associated with significant morbidity and mortality. Moreover, an asymptomatic carrier state can persist following acute infection, promoting NoV s
Externí odkaz:
https://doaj.org/article/4c034efe35d1417e8a25fb06c934a3d6
Autor:
Raffaello Verardi, Lisa C. Lindesmith, Yaroslav Tsybovsky, Jason Gorman, Gwo-Yu Chuang, Caitlin E. Edwards, Paul D. Brewer-Jensen, Michael L. Mallory, Li Ou, Arne Schön, Wei Shi, Ena S. Tully, George Georgiou, Ralph S. Baric, Peter D. Kwong
Publikováno v:
npj Vaccines, Vol 5, Iss 1, Pp 1-10 (2020)
Abstract Human noroviruses are non-enveloped, single-strand RNA viruses that cause pandemic outbreaks of acute gastroenteritis. A bivalent vaccine containing GI.1 and GII.4 virus-like particles (VLPs) has been shown to be safe and highly immunogenic,
Externí odkaz:
https://doaj.org/article/291f486fe191490c902890335db78af5
Autor:
Lisa C. Lindesmith, Paul D. Brewer-Jensen, Michael L. Mallory, Kara Jensen, Boyd L. Yount, Veronica Costantini, Matthew H. Collins, Caitlin E. Edwards, Timothy P. Sheahan, Jan Vinjé, Ralph S. Baric
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 2, Pp 245-267 (2020)
Background & Aims: Human norovirus infection is the leading cause of acute gastroenteritis. Genetic polymorphisms, mediated by the FUT2 gene (secretor enzyme), define strain susceptibility. Secretors express a diverse set of fucosylated histoblood gr
Externí odkaz:
https://doaj.org/article/3484e4d9803740ed909d74552cd41c97
Autor:
Paul D. Brewer-Jensen, Yaoska Reyes, Sylvia Becker-Dreps, Fredman González, Michael L. Mallory, Lester Gutiérrez, Omar Zepeda, Edwing Centeno, Nadja Vielot, Marta Diez-Valcarce, Jan Vinjé, Ralph Baric, Lisa C. Lindesmith, Filemon Bucardo
Publikováno v:
Viruses, Vol 14, Iss 9, p 2053 (2022)
There are significant challenges to the development of a pediatric norovirus vaccine, mainly due to the antigenic diversity among strains infecting young children. Characterizing human norovirus serotypes and understanding norovirus immunity in naïv
Externí odkaz:
https://doaj.org/article/23980db551ab49058291f104a6a87c3a
Autor:
Ryan D. Wuebbles, Vivian Cruz, Pam Van Ry, Pamela Barraza-Flores, Paul D. Brewer, Peter Jones, Dean J. Burkin
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss , Pp 145-153 (2019)
Duchenne muscular dystrophy (DMD) is a devastating disease caused by mutations in the dystrophin gene that result in the complete absence of dystrophin protein. We have shown previously that recombinant mouse Galectin-1 treatment improves physiologic
Externí odkaz:
https://doaj.org/article/7cb9207feebe46a59941dbb479c9bbe1
Autor:
Lisa C. Lindesmith, Paul D. Brewer-Jensen, Michael L. Mallory, Mark R. Zweigart, Samantha R. May, Daniel Kelly, Rachel Williams, Sylvia Becker-Dreps, Filemón Bucardo, David J. Allen, Judith Breuer, Ralph S. Baric
Publikováno v:
Viruses, Vol 14, Iss 6, p 1293 (2022)
Human norovirus is a leading cause of acute gastroenteritis, driven by antigenic variants within the GII.4 genotype. Antibody responses to GII.4 vaccination in adults are shaped by immune memory. How children without extensive immune memory will resp
Externí odkaz:
https://doaj.org/article/36db4f49fa9947d18da9223f2b529922
Autor:
Michael L. Mallory, Lisa C. Lindesmith, Paul D. Brewer-Jensen, Rachel L. Graham, Ralph S. Baric
Publikováno v:
Viruses, Vol 12, Iss 9, p 989 (2020)
Human norovirus (HuNoV) is the leading cause of global infectious acute gastroenteritis, causing ~20% of reported diarrheal episodes. Typically, GII.4 strains cause 50–70% of yearly outbreaks, and pandemic waves of disease approximately every 2–7
Externí odkaz:
https://doaj.org/article/af393fd5e40d4700844dc80210591773