Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Paul D. Boucher"'
Publikováno v:
Journal of Cancer Therapy. :1190-1202
Background: Gap junctions enable small molecules to diffuse between adjacent cells and have been associated with greater cytotoxicity of radiation and anti-cancer drugs. We investigated whether this gap junctional intercellular communication (GJIC) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4faeca6c2be51916095396ec580d29d
https://doi.org/10.4236/jct.2014.513121
https://doi.org/10.4236/jct.2014.513121
Autor:
Tico S. Thepsourinthone, Paul D. Boucher, Brendon Ladd, Sheryl A. Flanagan, Donna S. Shewach, John A. Secrist, Mike M. Im, Jessica J. O’Konek
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 684:1-10
Nucleoside analogs are efficacious cancer chemotherapeutics due to their incorporation into tumor cell DNA. However, they exhibit vastly different antitumor efficacies, suggesting that incorporation produces divergent effects on DNA replication. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e74671396996e23d1d9c21a94932dc8
https://doi.org/10.1016/j.mrfmmm.2009.11.011
https://doi.org/10.1016/j.mrfmmm.2009.11.011
Publikováno v:
Cancer gene therapy
Suicide gene therapy with herpes simplex virus thymidine kinase and ganciclovir is notable for producing multi-log cytotoxicity in a unique pattern of delayed cytotoxicity in S-phase. Because hydroxyurea, a ribonucleotide reductase inhibitor that act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813b5c304cbe80a25bfcc7ca22b27074
https://doi.org/10.1038/cgt.2009.16
https://doi.org/10.1038/cgt.2009.16
Publikováno v:
Cancer Research. 66:3845-3851
Suicide gene therapy with the herpes simplex virus thymidine kinase (HSV-TK) cDNA and ganciclovir can elicit cytotoxicity to transgene-expressing and nonexpressing bystander cells via transfer of ganciclovir phosphates through gap junctions. HeLa cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f84ac7943e32ca4710a350399fc3facc
https://doi.org/10.1158/0008-5472.can-05-3660
https://doi.org/10.1158/0008-5472.can-05-3660
Publikováno v:
Cancer Research. 66:3230-3237
The combination of cytosine deaminase (CD) and herpes simplex virus thymidine kinase (HSV-TK) suicide gene protocols has resulted in enhanced antitumor activity in cultured tumor cells and animal models. In this study, we show that concurrent additio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a87acab36acf5eba2bc96c9b5b68a97
https://doi.org/10.1158/0008-5472.can-05-3033
https://doi.org/10.1158/0008-5472.can-05-3033
Autor:
Paul D. Boucher, Donna S. Shewach
Publikováno v:
Molecular Therapy. 12:1064-1071
To improve bystander cell killing with HSV-TK/GCV, we have utilized dFdCyd to reduce endogenous dGTP, which competes with GCVTP for incorporation into DNA. In this study we demonstrate the ability of dFdCyd to enhance GCV-mediated bystander cytotoxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17873dc70994645ccb1ae6a32f9f49a3
https://doi.org/10.1016/j.ymthe.2005.07.643
https://doi.org/10.1016/j.ymthe.2005.07.643
Autor:
Martha J. Fernstrom, Randall J. Ruch, Lucas D. Koffler, Paul D. Boucher, Donna S. Shewach, George A. Abou-Rjaily
Publikováno v:
Experimental and Molecular Pathology. 73:54-60
Gap junctional intercellular communication and expression of gap junction proteins (connexins) are decreased frequently in neoplastic cells including human ovarian carcinoma cells. In order to test the hypothesis that these changes contribute to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4215f1b410598f834fd563b63297d3fb
https://doi.org/10.1006/exmp.2002.2436
https://doi.org/10.1006/exmp.2002.2436
Publikováno v:
Gene Therapy. 9:1023-1030
We have previously demonstrated with several cell lines in vitro that hydroxyurea (HU) synergistically enhances ganciclovir (GCV)-mediated cytotoxicity in bystander cells. In this study, we evaluated the role of DNA synthesis inhibition on enhanced b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b823740e24dbb9369664de4f285eb9
https://doi.org/10.1038/sj.gt.3301730
https://doi.org/10.1038/sj.gt.3301730
Autor:
Paul D. Boucher, Blaine W. Robinson, Donna S. Shewach, Anna L. Blobaum, Laura Zerbe, William B. Parker, Jennifer L. Vuletich, John A. Secrist, Patrick J. Murphy
Publikováno v:
Human Gene Therapy. 13:543-551
Ganciclovir (GCV) is widely used as a prodrug for selective activation in tumor cells expressing herpes simplex virus thymidine kinase (HSV-TK) because of its ability to induce multi-log cytotoxicity to HSV-TK-expressing as well as nonexpressing byst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d98dd9f34c3ded75e9e174e014704e92
https://doi.org/10.1089/10430340252809838
https://doi.org/10.1089/10430340252809838
Autor:
Jeannie Price, Mitchell D. Smith, Michelle R Petrak, Latisha Carter, Elizabeth Blachly-Dyson, B. McCauley Roy, Gowri Reddy, Michael Forte, Kenneth N. Barton, Keith Verner, Paul D. Boucher
Publikováno v:
Journal of Biological Chemistry. 270:28331-28336
Various point mutations of lysyl residues in yeast mitochondrial porin (283 residues) were tested for their ability to assemble in vitro into the outer membranes of intact yeast mitochondria. Assembly was evaluated by protection from proteinases. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56cdb5d04ee75a6625c273869b7be360
https://doi.org/10.1074/jbc.270.47.28331
https://doi.org/10.1074/jbc.270.47.28331