Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Paul D. Bonnitcha"'
Publikováno v:
Clinical chemistry and laboratory medicineReferences. 59(12)
Objectives In the clinical setting, the analysis and quantification of vitamin C (ascorbic acid) poses several challenges including analyte instability and poor retention by reverse phase HPLC systems. In this article we describe a rapid hydrophilic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c07fa9775fc4480e325685723e3690a7
https://pubmed.ncbi.nlm.nih.gov/34473921
https://pubmed.ncbi.nlm.nih.gov/34473921
Publikováno v:
Free Radical Biology and Medicine. 126:296-312
Tissue hypoxia is a key feature of many important causes of morbidity and mortality. In pathologies such as stroke, peripheral vascular disease and ischaemic heart disease, hypoxia is largely a consequence of low blood flow induced ischaemia, hence p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d49cde9b94fc4fbb816f749d9f3f568e
https://doi.org/10.1016/j.freeradbiomed.2018.08.019
https://doi.org/10.1016/j.freeradbiomed.2018.08.019
Autor:
Gavin Marx, Heidi Fettke, Megan Crumbaker, Kate L. Mahon, Anthony M. Joshua, Kevin Huynh, Ian D. Davis, Pan Du, Arun Azad, Martin R. Stockler, Thomas G. Meikle, Nicole K. Yeung, Phillip D. Stricker, Tahlia Scheinberg, Paul D. Bonnitcha, Karen Briscoe, Shidong Jia, Hui-Ming Lin, Lisa G. Horvath, Ben Tran, Alison Yan Zhang, Natalie A. Mellett, Michael Fitzpatrick, Peter J. Meikle, Edmond M. Kwan, Blossom Mak, Lisa M. Butler, David R. Sullivan, Jianjun Yu
Publikováno v:
EBioMedicine, Vol 72, Iss, Pp 103625-(2021)
EBioMedicine
EBioMedicine
Background Intrinsic resistance to androgen receptor signalling inhibitors (ARSI) occurs in 20–30% of men with metastatic castration-resistant prostate cancer (mCRPC). Ceramide metabolism may have a role in ARSI resistance. Our study's aim is to in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5b6c29bf6fa96af79576629ab0cfcec
https://doi.org/10.1016/j.ebiom.2021.103625
https://doi.org/10.1016/j.ebiom.2021.103625
Autor:
Anna K. Renfrew, Stuart M. Grieve, Paul D. Bonnitcha, Elizabeth J. New, G. H. Yin, Edward O'Neill, Jacek L. Kolanowski, Kathryn M. Broadhouse
Publikováno v:
RSC Advances. 6:30021-30027
Cobalt complexes have been extensively used for their catalytic and solid-state magnetic properties, but the solution-state magnetic properties have not yet been widely exploited. Two versatile cobalt ligand scaffolds were investigated for their magn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f671e3af2c1dc101dc8b01e4cd1f8e3b
https://doi.org/10.1039/c6ra04643f
https://doi.org/10.1039/c6ra04643f
Publikováno v:
Circulation: Genomic and Precision Medicine. 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5c5b3f96ab4bb035341c756ed3d3f87
https://doi.org/10.1161/circgen.118.002247
https://doi.org/10.1161/circgen.118.002247
Autor:
Edward O'Neill, Anna K. Renfrew, Philip W. Kuchel, Paul D. Bonnitcha, Dmitry Shishmarev, Amandeep Kaur, Gemma A. Figtree, Elizabeth J. New, David P. Bishop, Stuart M. Grieve
Publikováno v:
Inorganic chemistry. 56(16)
Dense tumors are resistant to conventional chemotherapies due to the unique tumor microenvironment characterized by hypoxic regions that promote cellular dormancy. Bioreductive drugs that are activated in response to this hypoxic environment are an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1efa29582884c1c14440929ab57c2384
https://pubmed.ncbi.nlm.nih.gov/28766939
https://pubmed.ncbi.nlm.nih.gov/28766939
Publikováno v:
Chemical communications (Cambridge, England). 53(25)
ParaSHIFT agents have shown promise in detecting chemical targets in biological systems by magnetic resonance, but few studies have used transition metal complexes for this purpose. Here we report our investigations into CoMe6trenCl (tren = tris(2-am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e6a5395b739c54038f0bb2ca0ea1991
https://pubmed.ncbi.nlm.nih.gov/28288215
https://pubmed.ncbi.nlm.nih.gov/28288215
Autor:
Dan Gibson, Ezequiel Wexselblatt, Alice V. Klein, Yousef Najajreh, Trevor W. Hambley, Paul D. Bonnitcha, Jenny Z. Zhang
Publikováno v:
Chemistry - A European Journal. 19:1672-1676
Facile strategies were developed for the versatile functionalization of platinum(IV) axial sites, allowing for easy accessibility to unsymmetric mono- and mixed-carboxylato, as well as symmetric di-substituted platinum(IV) complexes. The first method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::613521a9a4427c1f8d904e068ab52d88
https://doi.org/10.1002/chem.201203159
https://doi.org/10.1002/chem.201203159
Autor:
Paul D. Bonnitcha, Jonathan R. Dilworth, Harriet S. R. Struthers, Andrew R. Cowley, Martin Christlieb
This paper reports the synthesis of bimetallic zinc thiosemicarbazone complexes with rigid aromatic linkers, using either 1,3- or 1,4- benzenediamines or 1,3- or 1,4- benzenedialdehydes as the basis of the linking groups. Non-rigid aliphatic diamines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011a5b210b48bb8790e71ad33989d127
https://ora.ox.ac.uk/objects/uuid:8c629ffc-5575-4429-bf24-68b9ef9551f3
https://ora.ox.ac.uk/objects/uuid:8c629ffc-5575-4429-bf24-68b9ef9551f3
Autor:
Jonathan R. Dilworth, Rebekka Hueting, Paul D. Bonnitcha, Jerome Declerck, Véronique Gouverneur, Robert King, Martin Christlieb, Laurence Carroll, Simon R. Bayly, Antony D. Gee, Romain Bejot
The synthesis of three pairs of orthogonally labelled fluorinated Cu bis(thiosemicarbazonato) complexes is presented. These are the first examples of (18)F-labelled Cu(II)-complexes designed to serve as new hypoxia selective PET tracers and as mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f99748e7303710c88adf4c8346505ab3
https://ora.ox.ac.uk/objects/uuid:5f2bb234-11cf-420a-9a81-d76559dbe3ba
https://ora.ox.ac.uk/objects/uuid:5f2bb234-11cf-420a-9a81-d76559dbe3ba