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pro vyhledávání: '"Paul D Simoncic"'
Publikováno v:
McGill Journal of Medicine, Vol 12, Iss 1 (2020)
N/A
Externí odkaz:
https://doaj.org/article/d184f52eb1994e18a4ce89ae85750660
Publikováno v:
McGill Journal of Medicine : MJM
McGill Journal of Medicine, Vol 12, Iss 1 (2020)
McGill Journal of Medicine, Vol 12, Iss 1 (2020)
As governments around the world attempt to prop up our ailing economies by developing large stimulus packages in an attempt to restore and promote new growth and development, it appears that both health and environment have taken a back seat when in
Autor:
Jose La Rose, Andrew Scotter, Marcel Deckert, Fabrice Sircoulomb, Yasuyoshi Ueki, Paul D. Simoncic, Feng Cong, Noam Levaot, Ioannis D. Dimitriou, Robert Rottapel, Shengqing Gu, Oleksandr Voytyuk, Arun A. Chandrakumar, Paul M. Krzyzanowski, Salima Janmohamed
Publikováno v:
Cell. 147(6):1324-1339
SUMMARY Cherubism is an autosomal-dominant syndrome characterized by inflammatory destructive bony lesions resulting in symmetrical deformities of the facial bones. Cherubism is caused by mutations in Sh3bp2, the gene that encodes the adaptor protein
Autor:
Amel Guezguez, Marcel Deckert, Xavier Mouska, Robert Rottapel, Paul D. Simoncic, Jean-Philippe Breittmayer, Claudine Blin-Wakkach
Publikováno v:
ResearcherID
Publikováno v:
Canadian journal of physiology and pharmacology. 84(7)
It has recently been demonstrated that the protein tyrosine phosphatase (PTP) PTP1B and the T-cell PTP (TC-PTP) target several substrates involved in immune cell signaling. Recent data have furthered the view of these 2 PTP members as key regulators
Autor:
Marc D. Grynpas, Paul D. Simoncic, Jose La Rose, Andrew Scotter, Adeline H.M. Ng, Thomas L. Willett, Noam Levaot, Salima Janmohamed, Chiachien J. Wang, Robert Rottapel, Ernst J Reichenberger, Ioannis D. Dimitriou
Publikováno v:
Bone. 48:S72
A fine balance between bone resorption by osteoclasts and bone formation by osteoblasts maintains bone homeostasis. In patients with cherubism, gain-of-function mutations in 3BP2, which is encoded by SH3-domain binding protein 2 (SH3BP2), cause cysti