Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Paul D Rennert"'
Autor:
Christine Ambrose, Lihe Su, Lan Wu, Fay J Dufort, Thomas Sanford, Alyssa Birt, Benjamin J Hackel, Andreas Hombach, Hinrich Abken, Roy R Lobb, Paul D Rennert
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0247701 (2021)
Successful CAR T cell therapy for the treatment of solid tumors requires exemplary CAR T cell expansion, persistence and fitness, and the ability to target tumor antigens safely. Here we address this constellation of critical attributes for successfu
Externí odkaz:
https://doaj.org/article/79b29881299c40a5997a27b51c18789e
B cell lymphoma therapy has been transformed by CD19-targeting cellular therapeutics that induce high clinical response rates and impressive remissions in relapsed and refractory patients. However, approximately half of all patients who respond to CD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9949e8e5fae34e571858b36f5aa9a8c1
https://doi.org/10.1101/2022.05.30.494010
https://doi.org/10.1101/2022.05.30.494010
Abstract 2759: CAR-T engager proteins for the treatment of B cell cancers and acute myeloid leukemia
Publikováno v:
Cancer Research. 82:2759-2759
Chimeric Antigen Receptor T cells targeting malignancies expressing CD19 (CAR19) have been widely successful, with products approved to treat B cell lymphomas (NHL) and B cell leukemia. A major limitation of CAR19 therapy is the steep relapse rate wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef7538d2f12d1c868ee9f65e1e02b023
https://doi.org/10.1158/1538-7445.am2022-2759
https://doi.org/10.1158/1538-7445.am2022-2759
Autor:
Stefano Angiari, Gabriela Constantin, Sheng Xiao, Vittorina Della Bianca, Vijay K. Kuchroo, Enrica Caterina Pietronigro, Simona Budui, Barbara Rossi, Tiziano Donnarumma, Paul D. Rennert, Elena Zenaro, Carlo Laudanna, José M. Casasnovas, Lara Toffali, Gennj Piacentino, Silvia Dusi
Publikováno v:
Immunity
SummarySelectins play a central role in leukocyte trafficking by mediating tethering and rolling on vascular surfaces. Here we have reported that T cell immunoglobulin and mucin domain 1 (TIM-1) is a P-selectin ligand. We have shown that human and mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab1adf79e58c1057336cb04815d4428
https://doi.org/10.1016/j.immuni.2014.03.004
https://doi.org/10.1016/j.immuni.2014.03.004
Autor:
Paul D. Rennert
Cancer care is undergoing a radical transformation as novel technologies are directed toward new treatments and personalized medicine. The most dramatic advances in the treatment of cancer have come from therapeutics that augment the immune response
Publikováno v:
Journal of Virology. 87:8327-8341
The cell surface receptor T cell immunoglobulin mucin domain 1 (TIM-1) dramatically enhances filovirus infection of epithelial cells. Here, we showed that key phosphatidylserine (PtdSer) binding residues of the TIM-1 IgV domain are critical for Ebola
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86a12db49f3b251ed24f9ae263d843a
https://doi.org/10.1128/jvi.01025-13
https://doi.org/10.1128/jvi.01025-13
Autor:
Paul D. Rennert
Publikováno v:
Novel Immunotherapeutic Approaches to the Treatment of Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8ea16171bab97b18b2b1b662e3533d0
https://doi.org/10.1007/978-3-319-29827-6
https://doi.org/10.1007/978-3-319-29827-6
Autor:
Paul D. Rennert
Publikováno v:
Novel Immunotherapeutic Approaches to the Treatment of Cancer ISBN: 9783319298252
The immunoglobulin superfamily (IgSF) is a large and highly diverse assemblage of related proteins that regulate many different biological processes. The name of the family is based on early studies demonstrating sequence similarity between the antib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57f1aa3002b0da67d1241e3d9a2f619a
https://doi.org/10.1007/978-3-319-29827-6_2
https://doi.org/10.1007/978-3-319-29827-6_2
Autor:
Christopher D. Thanos, Paul D. Rennert
Publikováno v:
Novel Immunotherapeutic Approaches to the Treatment of Cancer ISBN: 9783319298252
Over a hundred years ago, Dr. Paul Erlich, the famed Nobel Laureate, postulated a “magic bullet theory” for targeted delivery of pharmaceutical agents. Antibody-drug conjugates (ADCs) are one manifestation of that theory and consist of a highly s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8751473bd33870d8af0ee3c2e5fd96a8
https://doi.org/10.1007/978-3-319-29827-6_8
https://doi.org/10.1007/978-3-319-29827-6_8
Autor:
Elizabeth Stepniak, Paul B. Rothman, Judit Knisz, John D. Colgan, Melody Singh, Paul D. Rennert, Geri L. Traver, Miranda L. Curtiss, Natalie Manhica, Bruce S. Hostager
Publikováno v:
Molecular Immunology. 48:1424-1431
The gene encoding T cell immunoglobulin and mucin domain-1 (TIM-1) is linked to atopy and asthma susceptibility in mice and humans. TIM-1 is a transmembrane protein expressed on activated lymphocytes and appears to have a role as a co-stimulatory rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed918f313da186f08bd576aed0a074a3
https://doi.org/10.1016/j.molimm.2011.03.023
https://doi.org/10.1016/j.molimm.2011.03.023